Nanofibrous biologically soluble scaffolds as an effective drug delivery system
In this article, the synthesis of biocompatible fibrous scaffolds with antimicrobial properties based on polycaprolactone/hydroxyapatite/amoxicillin and study of their surface morphology, antimicrobial effect, and drug release are discussed. Hydroxyapatite (1–2 $\mu $m, 97%) synthesized from biologi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2021-02-01
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| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.58/ |
| _version_ | 1797651364468228096 |
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| author | Daulbayev, Chingis Sultanov, Fail Aldasheva, Maiya Abdybekova, Aliya Bakbolat, Baglan Shams, Mohammad Chekiyeva, Aruzhan Mansurov, Zulkhair |
| author_facet | Daulbayev, Chingis Sultanov, Fail Aldasheva, Maiya Abdybekova, Aliya Bakbolat, Baglan Shams, Mohammad Chekiyeva, Aruzhan Mansurov, Zulkhair |
| author_sort | Daulbayev, Chingis |
| collection | DOAJ |
| description | In this article, the synthesis of biocompatible fibrous scaffolds with antimicrobial properties based on polycaprolactone/hydroxyapatite/amoxicillin and study of their surface morphology, antimicrobial effect, and drug release are discussed. Hydroxyapatite (1–2 $\mu $m, 97%) synthesized from biologically waste material (eggshell) was added to the composite scaffolds as a bone-replacement material. The scaffolds’ antimicrobial properties were evaluated against S. aureus and E. faecalis. The scaffolds possessed a sustained drug release from the scaffolds amounted to about 94% of the antibiotic’s total weight over a 4-week observation period. Agar diffusion confirmed the antimicrobial properties of the scaffolds against specific bacteria. |
| first_indexed | 2024-03-11T16:13:57Z |
| format | Article |
| id | doaj.art-212fe570336145508d99309d77ba6460 |
| institution | Directory Open Access Journal |
| issn | 1878-1543 |
| language | English |
| last_indexed | 2024-03-11T16:13:57Z |
| publishDate | 2021-02-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj.art-212fe570336145508d99309d77ba64602023-10-24T14:22:52ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432021-02-012411910.5802/crchim.5810.5802/crchim.58Nanofibrous biologically soluble scaffolds as an effective drug delivery systemDaulbayev, Chingis0Sultanov, Fail1Aldasheva, Maiya2Abdybekova, Aliya3Bakbolat, Baglan4Shams, Mohammad5Chekiyeva, Aruzhan6Mansurov, Zulkhair7al-Farabi Kazakh National University, 050038, Almaty, Kazakhstan; Institute of Combustion Problems, 050012, Almaty, Kazakhstanal-Farabi Kazakh National University, 050038, Almaty, Kazakhstan; Institute of Combustion Problems, 050012, Almaty, KazakhstanS.D. Asfendiyarov Kazakh National Medical University, 050012, Almaty, KazakhstanKazakh Medical University of Continuing Education, 050040, Almaty, Kazakhstanal-Farabi Kazakh National University, 050038, Almaty, Kazakhstan; Institute of Combustion Problems, 050012, Almaty, Kazakhstanal-Farabi Kazakh National University, 050038, Almaty, Kazakhstan; Institute of Combustion Problems, 050012, Almaty, KazakhstanK.I. Satbayev Kazakh National Research Technical University, 050013, Almaty, Kazakhstanal-Farabi Kazakh National University, 050038, Almaty, Kazakhstan; Institute of Combustion Problems, 050012, Almaty, KazakhstanIn this article, the synthesis of biocompatible fibrous scaffolds with antimicrobial properties based on polycaprolactone/hydroxyapatite/amoxicillin and study of their surface morphology, antimicrobial effect, and drug release are discussed. Hydroxyapatite (1–2 $\mu $m, 97%) synthesized from biologically waste material (eggshell) was added to the composite scaffolds as a bone-replacement material. The scaffolds’ antimicrobial properties were evaluated against S. aureus and E. faecalis. The scaffolds possessed a sustained drug release from the scaffolds amounted to about 94% of the antibiotic’s total weight over a 4-week observation period. Agar diffusion confirmed the antimicrobial properties of the scaffolds against specific bacteria.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.58/ElectrospinningHydroxyapatiteBiologically soluble scaffoldsFibersDrugs |
| spellingShingle | Daulbayev, Chingis Sultanov, Fail Aldasheva, Maiya Abdybekova, Aliya Bakbolat, Baglan Shams, Mohammad Chekiyeva, Aruzhan Mansurov, Zulkhair Nanofibrous biologically soluble scaffolds as an effective drug delivery system Comptes Rendus. Chimie Electrospinning Hydroxyapatite Biologically soluble scaffolds Fibers Drugs |
| title | Nanofibrous biologically soluble scaffolds as an effective drug delivery system |
| title_full | Nanofibrous biologically soluble scaffolds as an effective drug delivery system |
| title_fullStr | Nanofibrous biologically soluble scaffolds as an effective drug delivery system |
| title_full_unstemmed | Nanofibrous biologically soluble scaffolds as an effective drug delivery system |
| title_short | Nanofibrous biologically soluble scaffolds as an effective drug delivery system |
| title_sort | nanofibrous biologically soluble scaffolds as an effective drug delivery system |
| topic | Electrospinning Hydroxyapatite Biologically soluble scaffolds Fibers Drugs |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.58/ |
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