An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives
Neuropeptides are mainly secreted from the human central and peripheral nervous systems. Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and perform various physiological functions. Conventional cancer treatments in clinical practice still present many drawbacks du...
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MDPI AG
2022-09-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/18/8990 |
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| author | Ankit Srivastava Deeksha Rikhari Biswajita Pradhan Kaushik Kumar Bharadwaj Antonio Gaballo Alessandra Quarta Mrutyunjay Jena Sameer Srivastava Andrea Ragusa |
| author_facet | Ankit Srivastava Deeksha Rikhari Biswajita Pradhan Kaushik Kumar Bharadwaj Antonio Gaballo Alessandra Quarta Mrutyunjay Jena Sameer Srivastava Andrea Ragusa |
| author_sort | Ankit Srivastava |
| collection | DOAJ |
| description | Neuropeptides are mainly secreted from the human central and peripheral nervous systems. Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and perform various physiological functions. Conventional cancer treatments in clinical practice still present many drawbacks due to the lack of selectivity toward the target cell, drug-resistance, and side-effects, thus pushing for the development of new therapeutic agents and therapies. Recent research suggests that neuropeptides influence cancer cell proliferation, invasion, metastasis, and angiogenesis and, therefore, they could be exploited as a target for novel anticancer therapies. Very recently, targeted approaches that inhibit neuropeptides and their associated receptors are being developed in cancer treatment. This review focuses on various neuropeptides and their potential utility as drug targets by different inhibitors as a recently identified approach to cancer prevention, with particular emphasis on colorectal cancer. |
| first_indexed | 2024-03-10T00:50:39Z |
| format | Article |
| id | doaj.art-2130e37f63cb4b98b06bf20ebb3212f4 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T00:50:39Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-2130e37f63cb4b98b06bf20ebb3212f42023-11-23T14:51:15ZengMDPI AGApplied Sciences2076-34172022-09-011218899010.3390/app12188990An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational PerspectivesAnkit Srivastava0Deeksha Rikhari1Biswajita Pradhan2Kaushik Kumar Bharadwaj3Antonio Gaballo4Alessandra Quarta5Mrutyunjay Jena6Sameer Srivastava7Andrea Ragusa8Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad 211004, IndiaDepartment of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad 211004, IndiaAlgal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, IndiaDepartment of Bioengineering and Technology, Guwahati University, Guwahati 781014, IndiaCNR-Nanotec, Institute of Nanotechnology, Via Monteroni, 73100 Lecce, ItalyCNR-Nanotec, Institute of Nanotechnology, Via Monteroni, 73100 Lecce, ItalyAlgal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, IndiaDepartment of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad 211004, IndiaCNR-Nanotec, Institute of Nanotechnology, Via Monteroni, 73100 Lecce, ItalyNeuropeptides are mainly secreted from the human central and peripheral nervous systems. Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and perform various physiological functions. Conventional cancer treatments in clinical practice still present many drawbacks due to the lack of selectivity toward the target cell, drug-resistance, and side-effects, thus pushing for the development of new therapeutic agents and therapies. Recent research suggests that neuropeptides influence cancer cell proliferation, invasion, metastasis, and angiogenesis and, therefore, they could be exploited as a target for novel anticancer therapies. Very recently, targeted approaches that inhibit neuropeptides and their associated receptors are being developed in cancer treatment. This review focuses on various neuropeptides and their potential utility as drug targets by different inhibitors as a recently identified approach to cancer prevention, with particular emphasis on colorectal cancer.https://www.mdpi.com/2076-3417/12/18/8990neuropeptidereceptorinhibitorscancertherapeutic agentsbombesin |
| spellingShingle | Ankit Srivastava Deeksha Rikhari Biswajita Pradhan Kaushik Kumar Bharadwaj Antonio Gaballo Alessandra Quarta Mrutyunjay Jena Sameer Srivastava Andrea Ragusa An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives Applied Sciences neuropeptide receptor inhibitors cancer therapeutic agents bombesin |
| title | An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives |
| title_full | An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives |
| title_fullStr | An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives |
| title_full_unstemmed | An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives |
| title_short | An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives |
| title_sort | insight into neuropeptides inhibitors in the biology of colorectal cancer opportunity and translational perspectives |
| topic | neuropeptide receptor inhibitors cancer therapeutic agents bombesin |
| url | https://www.mdpi.com/2076-3417/12/18/8990 |
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