The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis
Abstract Background Intracardiac leiomyomatosis (ICLM) is a rare life-threatening form of intravenous leiomyomatosis (IVLM). The incomplete resection and recurrence are associated with high morbidity and mortality. The objective of this study is to identify that whether estrogen deprivation therapie...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Orphanet Journal of Rare Diseases |
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| Online Access: | https://doi.org/10.1186/s13023-021-02087-7 |
| _version_ | 1819011162466942976 |
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| author | Jinxiao Liang Ruilin Lei Mingwei Xie Shaodan Lin Jing Xu Xiaoting Ling Qingsheng Xie |
| author_facet | Jinxiao Liang Ruilin Lei Mingwei Xie Shaodan Lin Jing Xu Xiaoting Ling Qingsheng Xie |
| author_sort | Jinxiao Liang |
| collection | DOAJ |
| description | Abstract Background Intracardiac leiomyomatosis (ICLM) is a rare life-threatening form of intravenous leiomyomatosis (IVLM). The incomplete resection and recurrence are associated with high morbidity and mortality. The objective of this study is to identify that whether estrogen deprivation therapies, including bilateral salpingo-oophorectomy (BSO)-based surgery and gonadotrophin releasing hormone agonists (GnRHa) administration, could bring benefits to patients with primary unresectable ICLM. Methods PubMed/MEDLINE (Ovid) was searched (up to May 2021) for studies reporting individual patient data on demographics, clinicopathological features, treatment, and follow-up information. Exclusion criteria were patients who may have been included in two or more publications. This study was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results A total of 114 patients from 70 papers were included. Several reports showed that the tumor in the right atrium and inferior vena cava shrank dramatically after BSO-based surgery, or GnRHa administrated preoperatively in premenopausal women. The rate of complete resection was 64.04% in patients with ICLM, which was 85.25% in no/slight adhesion and no pulmonary nodules group, while 22.22% in firm/extensive adhesion and/or pulmonary nodules group (p < 0.0001). Meanwhile, the recurrence rates in patients with complete resection and incomplete resection were 4.29% and 37.84% respectively (p < 0.0001). Furthermore, complete resection with BSO had the lowest recurrence rate of 3.13%, incomplete resection with BSO had a progression rate of 45.45%, while incomplete resection with ovarian preservation had the highest progression rate of 75.00%. Conclusions The recurrence rate of ICLM was closely related to firm/extensive adhesion in IVC or above, and/or pulmonary nodules. BSO-based surgery might reduce the recurrence rate no matter ICLM could be completely resected or not. In addition, estrogen deprivation therapies could decrease tumor burden as a primary treatment, and further make a secondary complete resection feasible in premenopausal women with initially unresectable ICLM. |
| first_indexed | 2024-12-21T01:23:46Z |
| format | Article |
| id | doaj.art-2131daa6b80740fea27be50244e79f53 |
| institution | Directory Open Access Journal |
| issn | 1750-1172 |
| language | English |
| last_indexed | 2024-12-21T01:23:46Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
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| series | Orphanet Journal of Rare Diseases |
| spelling | doaj.art-2131daa6b80740fea27be50244e79f532022-12-21T19:20:34ZengBMCOrphanet Journal of Rare Diseases1750-11722021-10-011611710.1186/s13023-021-02087-7The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysisJinxiao Liang0Ruilin Lei1Mingwei Xie2Shaodan Lin3Jing Xu4Xiaoting Ling5Qingsheng Xie6Department of Gynecological Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gynecological Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gynecological Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gynecological Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gynecological Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityDepartment of Gynecological Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityAbstract Background Intracardiac leiomyomatosis (ICLM) is a rare life-threatening form of intravenous leiomyomatosis (IVLM). The incomplete resection and recurrence are associated with high morbidity and mortality. The objective of this study is to identify that whether estrogen deprivation therapies, including bilateral salpingo-oophorectomy (BSO)-based surgery and gonadotrophin releasing hormone agonists (GnRHa) administration, could bring benefits to patients with primary unresectable ICLM. Methods PubMed/MEDLINE (Ovid) was searched (up to May 2021) for studies reporting individual patient data on demographics, clinicopathological features, treatment, and follow-up information. Exclusion criteria were patients who may have been included in two or more publications. This study was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results A total of 114 patients from 70 papers were included. Several reports showed that the tumor in the right atrium and inferior vena cava shrank dramatically after BSO-based surgery, or GnRHa administrated preoperatively in premenopausal women. The rate of complete resection was 64.04% in patients with ICLM, which was 85.25% in no/slight adhesion and no pulmonary nodules group, while 22.22% in firm/extensive adhesion and/or pulmonary nodules group (p < 0.0001). Meanwhile, the recurrence rates in patients with complete resection and incomplete resection were 4.29% and 37.84% respectively (p < 0.0001). Furthermore, complete resection with BSO had the lowest recurrence rate of 3.13%, incomplete resection with BSO had a progression rate of 45.45%, while incomplete resection with ovarian preservation had the highest progression rate of 75.00%. Conclusions The recurrence rate of ICLM was closely related to firm/extensive adhesion in IVC or above, and/or pulmonary nodules. BSO-based surgery might reduce the recurrence rate no matter ICLM could be completely resected or not. In addition, estrogen deprivation therapies could decrease tumor burden as a primary treatment, and further make a secondary complete resection feasible in premenopausal women with initially unresectable ICLM.https://doi.org/10.1186/s13023-021-02087-7Intracardiac leiomyomatosisEstrogen deprivation therapyPrimary treatmentBilateral salpingo-oophorectomyGonadotrophin releasing hormone agonists |
| spellingShingle | Jinxiao Liang Ruilin Lei Mingwei Xie Shaodan Lin Jing Xu Xiaoting Ling Qingsheng Xie The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis Orphanet Journal of Rare Diseases Intracardiac leiomyomatosis Estrogen deprivation therapy Primary treatment Bilateral salpingo-oophorectomy Gonadotrophin releasing hormone agonists |
| title | The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis |
| title_full | The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis |
| title_fullStr | The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis |
| title_full_unstemmed | The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis |
| title_short | The role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis: a systematic review and meta-analysis |
| title_sort | role of estrogen deprivation therapy in premenopausal women with primary unresectable intracardiac leiomyomatosis a systematic review and meta analysis |
| topic | Intracardiac leiomyomatosis Estrogen deprivation therapy Primary treatment Bilateral salpingo-oophorectomy Gonadotrophin releasing hormone agonists |
| url | https://doi.org/10.1186/s13023-021-02087-7 |
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