15-Deoxy-Delta12,14-prostaglandin J2 modifies components of the proteasome and inhibits inflammatory responses in human endothelial cells

15-Deoxy-Delta12,14-prostaglandin J2 modifies components of the proteasome and inhibits inflammatory responses in human endothelial cells

15-Deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) is an electrophilic lipid mediator derived from PGD2 with potent anti-inflammatory effects. These are likely to be due to the covalent modification of cellular proteins, via a reactive α,β-unsaturated carbonyl group in its cyclopentenone ring. This stu...

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Bibliographic Details
Main Authors:	Simone Marcone, Paul Evans, Desmond J Fitzgerald
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-10-01
Series:	Frontiers in Immunology
Subjects:	Atherosclerosis Chemokines Inflammation Adhesion molecules Proteasome Monocyte adhesion
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00459/full

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