Folic acid-conjugated magnetic triblock copolymer nanoparticles for dual targeted delivery of 5-fluorouracil to colon cancer cells

Folic acid-conjugated magnetic triblock copolymer nanoparticles for dual targeted delivery of 5-fluorouracil to colon cancer cells

Abstract Background In the current study, folic acid-conjugated PEG-PCL-PEG triblock copolymer were synthesized and loaded with 5-fluorouracil and magnetite nanoparticles (5-FU-SPION-PEG-PCL-PEG-FA) for targeted delivery of drug to HT29 human colon cancer cells and CT26 mouse colon cancer model. The...

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Bibliographic Details
Main Authors: Parvin Sadat Mirzaghavami, Samideh Khoei, Sepideh Khoee, Sakine Shirvalilou
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cancer Nanotechnology
Subjects:
Targeted drug delivery
Magnetite nanoparticles
Folic acid
Colon cancer
5-Fluorouracil
Online Access:https://doi.org/10.1186/s12645-022-00120-3

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