Epidemiology and Clinical Characteristics of Seasonal Human Coronaviruses in Children Hospitalized in Hebei Province, China Before and During the COVID-19 Pandemic
Meng-Chuan Zhao,1 Chan Wen,2 Ling Sun,2 Su-xia Duan,1 Ke-xin Zang,3 Le Wang,1 Xiao-Wei Cui4 1Department of Laborotory Medicine, Children’s Hospital of Hebei Province, Shijiazhuang, People’s Republic of China; 2Department of Medical, Children’s Hospital of Hebei Province, Shijiazhuang, People’s Repub...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-09-01
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| Series: | Risk Management and Healthcare Policy |
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| Online Access: | https://www.dovepress.com/epidemiology-and-clinical-characteristics-of-seasonal-human-coronaviru-peer-reviewed-fulltext-article-RMHP |
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| author | Zhao MC Wen C Sun L Duan SX Zang KX Wang L Cui XW |
| author_facet | Zhao MC Wen C Sun L Duan SX Zang KX Wang L Cui XW |
| author_sort | Zhao MC |
| collection | DOAJ |
| description | Meng-Chuan Zhao,1 Chan Wen,2 Ling Sun,2 Su-xia Duan,1 Ke-xin Zang,3 Le Wang,1 Xiao-Wei Cui4 1Department of Laborotory Medicine, Children’s Hospital of Hebei Province, Shijiazhuang, People’s Republic of China; 2Department of Medical, Children’s Hospital of Hebei Province, Shijiazhuang, People’s Republic of China; 3Hebei Medical University, Shijiazhuang, People’s Republic of China; 4Children’s Hospital of Hebei Province, Shijiazhuang, People’s Republic of ChinaCorrespondence: Xiao-Wei Cui, Children’s Hospital of Hebei Province, No. 133 of JianHua Street, Shijiazhuang, 050031, People’s Republic of China, Tel +86 18503292016, Fax +86 031185911109, Email cuixiaoweicxw@126.comBackground: This study aimed to assess the impact of the COVID-19 pandemic on the prevalence and clinical characteristics of seasonal human coronavirus (HCoV) infections among children hospitalized in Hebei, China.Methods: We examined nasopharyngeal aspirate (NPA) specimens for seasonal HCoVs from January 2018 to December 2021, at the Children’s Hospital of Hebei Province. We used a GeXP-based multiplex reverse transcription PCR assay for the detection of 11 common respiratory viruses (including seasonal HCoVs), chlamydia, and Mycoplasma pneumoniae. The demographic and clinical characteristics of children who tested positive for seasonal HCoVs were recorded and analyzed.Results: A total of 377 (1.96%) of the 19,248 specimens from 2018 to 2019 and 263 (1.96%) of the 13,426 specimens from 2020 to 2021 exhibited seasonal HCoVs. Compared to 2018 and 2019, the positive rate of seasonal HCoVs was lower from January to July of 2020 and increased beginning in August 2020, peaking in the autumn and winter. In 2020– 2021, nasal blockage and swollen adenoids were detected more frequently in children who tested positive for seasonal HCoVs. During 2018– 2019, however, the duration of fever was significantly longer, and cough and dyspnea were more prominent among children who had fallen ill. In addition, seasonal HCoV-positive patients in 2018– 2019 were more likely to experience complications, had a higher risk of severe community-acquired pneumonia (CAP), and had a tendency to require a longer hospital stay than patients in 2020– 2021.Conclusion: According to our findings, there were significant changes in the epidemiology of seasonal HCoVs in Hebei, China during the COVID-19 pandemic, and children infected with seasonal HCoVs usually experienced milder clinical symptoms during the pandemic than before it.Keywords: children, clinical characteristics, COVID-19 pandemic, epidemiology, Seasonal human coronavirus |
| first_indexed | 2024-03-12T00:44:50Z |
| format | Article |
| id | doaj.art-21330c76f0084bbe942d535ea7b4697e |
| institution | Directory Open Access Journal |
| issn | 1179-1594 |
| language | English |
| last_indexed | 2024-03-12T00:44:50Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Risk Management and Healthcare Policy |
| spelling | doaj.art-21330c76f0084bbe942d535ea7b4697e2023-09-14T19:09:01ZengDove Medical PressRisk Management and Healthcare Policy1179-15942023-09-01Volume 161801180786554Epidemiology and Clinical Characteristics of Seasonal Human Coronaviruses in Children Hospitalized in Hebei Province, China Before and During the COVID-19 PandemicZhao MCWen CSun LDuan SXZang KXWang LCui XWMeng-Chuan Zhao,1 Chan Wen,2 Ling Sun,2 Su-xia Duan,1 Ke-xin Zang,3 Le Wang,1 Xiao-Wei Cui4 1Department of Laborotory Medicine, Children’s Hospital of Hebei Province, Shijiazhuang, People’s Republic of China; 2Department of Medical, Children’s Hospital of Hebei Province, Shijiazhuang, People’s Republic of China; 3Hebei Medical University, Shijiazhuang, People’s Republic of China; 4Children’s Hospital of Hebei Province, Shijiazhuang, People’s Republic of ChinaCorrespondence: Xiao-Wei Cui, Children’s Hospital of Hebei Province, No. 133 of JianHua Street, Shijiazhuang, 050031, People’s Republic of China, Tel +86 18503292016, Fax +86 031185911109, Email cuixiaoweicxw@126.comBackground: This study aimed to assess the impact of the COVID-19 pandemic on the prevalence and clinical characteristics of seasonal human coronavirus (HCoV) infections among children hospitalized in Hebei, China.Methods: We examined nasopharyngeal aspirate (NPA) specimens for seasonal HCoVs from January 2018 to December 2021, at the Children’s Hospital of Hebei Province. We used a GeXP-based multiplex reverse transcription PCR assay for the detection of 11 common respiratory viruses (including seasonal HCoVs), chlamydia, and Mycoplasma pneumoniae. The demographic and clinical characteristics of children who tested positive for seasonal HCoVs were recorded and analyzed.Results: A total of 377 (1.96%) of the 19,248 specimens from 2018 to 2019 and 263 (1.96%) of the 13,426 specimens from 2020 to 2021 exhibited seasonal HCoVs. Compared to 2018 and 2019, the positive rate of seasonal HCoVs was lower from January to July of 2020 and increased beginning in August 2020, peaking in the autumn and winter. In 2020– 2021, nasal blockage and swollen adenoids were detected more frequently in children who tested positive for seasonal HCoVs. During 2018– 2019, however, the duration of fever was significantly longer, and cough and dyspnea were more prominent among children who had fallen ill. In addition, seasonal HCoV-positive patients in 2018– 2019 were more likely to experience complications, had a higher risk of severe community-acquired pneumonia (CAP), and had a tendency to require a longer hospital stay than patients in 2020– 2021.Conclusion: According to our findings, there were significant changes in the epidemiology of seasonal HCoVs in Hebei, China during the COVID-19 pandemic, and children infected with seasonal HCoVs usually experienced milder clinical symptoms during the pandemic than before it.Keywords: children, clinical characteristics, COVID-19 pandemic, epidemiology, Seasonal human coronavirushttps://www.dovepress.com/epidemiology-and-clinical-characteristics-of-seasonal-human-coronaviru-peer-reviewed-fulltext-article-RMHPchildrenclinical characteristicscovid-19 pandemicepidemiologyseasonal human coronavirus |
| spellingShingle | Zhao MC Wen C Sun L Duan SX Zang KX Wang L Cui XW Epidemiology and Clinical Characteristics of Seasonal Human Coronaviruses in Children Hospitalized in Hebei Province, China Before and During the COVID-19 Pandemic Risk Management and Healthcare Policy children clinical characteristics covid-19 pandemic epidemiology seasonal human coronavirus |
| title | Epidemiology and Clinical Characteristics of Seasonal Human Coronaviruses in Children Hospitalized in Hebei Province, China Before and During the COVID-19 Pandemic |
| title_full | Epidemiology and Clinical Characteristics of Seasonal Human Coronaviruses in Children Hospitalized in Hebei Province, China Before and During the COVID-19 Pandemic |
| title_fullStr | Epidemiology and Clinical Characteristics of Seasonal Human Coronaviruses in Children Hospitalized in Hebei Province, China Before and During the COVID-19 Pandemic |
| title_full_unstemmed | Epidemiology and Clinical Characteristics of Seasonal Human Coronaviruses in Children Hospitalized in Hebei Province, China Before and During the COVID-19 Pandemic |
| title_short | Epidemiology and Clinical Characteristics of Seasonal Human Coronaviruses in Children Hospitalized in Hebei Province, China Before and During the COVID-19 Pandemic |
| title_sort | epidemiology and clinical characteristics of seasonal human coronaviruses in children hospitalized in hebei province china before and during the covid 19 pandemic |
| topic | children clinical characteristics covid-19 pandemic epidemiology seasonal human coronavirus |
| url | https://www.dovepress.com/epidemiology-and-clinical-characteristics-of-seasonal-human-coronaviru-peer-reviewed-fulltext-article-RMHP |
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