Inflammatory arthritis and eye diseases: a Mendelian randomization study
ObjectivesThe aim of this study was to determine causal associations between inflammatory arthritis and eye diseases (disorders of sclera, cornea, iris, and ciliary body [DSCIC] and disorders of choroid and retina [DCR]).MethodsGenome-wide association studies’ summary data of rheumatoid arthritis (R...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1251167/full |
| _version_ | 1797663250943311872 |
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| author | Xinlin Nie Zhaoliang Liu Dongheng Xie Yang Sun |
| author_facet | Xinlin Nie Zhaoliang Liu Dongheng Xie Yang Sun |
| author_sort | Xinlin Nie |
| collection | DOAJ |
| description | ObjectivesThe aim of this study was to determine causal associations between inflammatory arthritis and eye diseases (disorders of sclera, cornea, iris, and ciliary body [DSCIC] and disorders of choroid and retina [DCR]).MethodsGenome-wide association studies’ summary data of rheumatoid arthritis (RA) from a large-scale meta-analysis were used to identify genetically predicted RA. UK Biobank source data predicted ankylosing spondylitis (AS), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA). Furthermore, data from the FinnGen Biobank were used to identify genetically predicted eye diseases. Two-sample Mendelian randomization analysis was used to assess the causal relationship between inflammatory arthritis and eye diseases in the European population. Inverse-variance weighting (IVW) was used as the primary method, while MR-Egger, weighted median, and MR-PRESSO outlier test were used to detect heterogeneity and pleiotropy.ResultsGenetically determined RA was indeed observed to have a causal effect on DSCIC (odds ratio [OR] = 1.084, p = 2.353 × 10−10) and DCR (OR = 1.151, p = 1.584 × 10−19). AS was causally associated with DSCIC (OR = 1.068, p < 2.024 × 10−8). In addition, PsA was also found to have a causal association with an increased risk of 17.9% for the development of DSCIC (OR = 1.179, p = 0.003). On the flip side, DSCIC increased the risk of JIA (OR = 2.276, p = 0.003).ConclusionOur study provided genetic evidence for the causal associations of RA, AS, and PsA with an increased risk of DSCIC, and a causal association between RA and DCR was also identified. In addition, DSCIC greatly increased the risk of JIA. |
| first_indexed | 2024-03-11T19:11:50Z |
| format | Article |
| id | doaj.art-21346156234948b3b426aece43c10fcb |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T19:11:50Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-21346156234948b3b426aece43c10fcb2023-10-09T11:17:40ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12511671251167Inflammatory arthritis and eye diseases: a Mendelian randomization studyXinlin NieZhaoliang LiuDongheng XieYang SunObjectivesThe aim of this study was to determine causal associations between inflammatory arthritis and eye diseases (disorders of sclera, cornea, iris, and ciliary body [DSCIC] and disorders of choroid and retina [DCR]).MethodsGenome-wide association studies’ summary data of rheumatoid arthritis (RA) from a large-scale meta-analysis were used to identify genetically predicted RA. UK Biobank source data predicted ankylosing spondylitis (AS), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA). Furthermore, data from the FinnGen Biobank were used to identify genetically predicted eye diseases. Two-sample Mendelian randomization analysis was used to assess the causal relationship between inflammatory arthritis and eye diseases in the European population. Inverse-variance weighting (IVW) was used as the primary method, while MR-Egger, weighted median, and MR-PRESSO outlier test were used to detect heterogeneity and pleiotropy.ResultsGenetically determined RA was indeed observed to have a causal effect on DSCIC (odds ratio [OR] = 1.084, p = 2.353 × 10−10) and DCR (OR = 1.151, p = 1.584 × 10−19). AS was causally associated with DSCIC (OR = 1.068, p < 2.024 × 10−8). In addition, PsA was also found to have a causal association with an increased risk of 17.9% for the development of DSCIC (OR = 1.179, p = 0.003). On the flip side, DSCIC increased the risk of JIA (OR = 2.276, p = 0.003).ConclusionOur study provided genetic evidence for the causal associations of RA, AS, and PsA with an increased risk of DSCIC, and a causal association between RA and DCR was also identified. In addition, DSCIC greatly increased the risk of JIA.https://www.frontiersin.org/articles/10.3389/fendo.2023.1251167/fullinflammatory arthritisrheumatoid arthritisankylosing spondylitispsoriatic arthritiseye diseasesMendelian randomization |
| spellingShingle | Xinlin Nie Zhaoliang Liu Dongheng Xie Yang Sun Inflammatory arthritis and eye diseases: a Mendelian randomization study Frontiers in Endocrinology inflammatory arthritis rheumatoid arthritis ankylosing spondylitis psoriatic arthritis eye diseases Mendelian randomization |
| title | Inflammatory arthritis and eye diseases: a Mendelian randomization study |
| title_full | Inflammatory arthritis and eye diseases: a Mendelian randomization study |
| title_fullStr | Inflammatory arthritis and eye diseases: a Mendelian randomization study |
| title_full_unstemmed | Inflammatory arthritis and eye diseases: a Mendelian randomization study |
| title_short | Inflammatory arthritis and eye diseases: a Mendelian randomization study |
| title_sort | inflammatory arthritis and eye diseases a mendelian randomization study |
| topic | inflammatory arthritis rheumatoid arthritis ankylosing spondylitis psoriatic arthritis eye diseases Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1251167/full |
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