Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea
<i>Background and objectives: We</i> aimed to analyze factors associated with the period of viral shedding in patients with confirmed COVID-19 who experienced only mild symptoms. <i>Materials and methods:</i> We conducted a multicenter retrospective study from three community...
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MDPI AG
2020-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/12/659 |
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| author | Bongyoung Kim Jang Wook Sohn Soomin Nam Jang Won Sohn Won Suk Choi Hyoung Seop Kim |
| author_facet | Bongyoung Kim Jang Wook Sohn Soomin Nam Jang Won Sohn Won Suk Choi Hyoung Seop Kim |
| author_sort | Bongyoung Kim |
| collection | DOAJ |
| description | <i>Background and objectives: We</i> aimed to analyze factors associated with the period of viral shedding in patients with confirmed COVID-19 who experienced only mild symptoms. <i>Materials and methods:</i> We conducted a multicenter retrospective study from three community treatment centers (CTCs) of South Korea. All patients included were admitted to the three centers before 31 March 2020. We collected data about clinical characteristics and the result of real-time reverse transcription polymerase chain reaction (RT-PCR). <i>Results:</i> Viral shedding was terminated within 32 days and 36 days in 75% and 90% of patients, respectively (range: 8–49 days). The mean period of viral shedding was 23.8 ± 8.7 days. In the multivariate Cox proportional hazards regression analysis, the existence of underlying comorbidities lowered the probability of the termination of viral shedding (HR = 0.561, 95% CI 0.388–0.812). Female sex and presence of COVID-19-associated symptoms also lowered the probability, but the significance was marginal. <i>Conclusions:</i> The existence of underlying comorbidities was associated with delayed termination of viral shedding in COVID-19 patients with mild severity. |
| first_indexed | 2024-03-12T11:01:13Z |
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| id | doaj.art-2139f19b41614d359cb91ec01431d7a9 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:01:13Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-2139f19b41614d359cb91ec01431d7a92023-09-02T05:33:36ZengMDPI AGMedicina1010-660X2020-11-015665965910.3390/medicina56120659Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South KoreaBongyoung Kim0Jang Wook Sohn1Soomin Nam2Jang Won Sohn3Won Suk Choi4Hyoung Seop Kim5Department of Internal Medicine, College of Medicine, Hanyang University, Seoul 04763, KoreaDepartment of Internal Medicine, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of General Surgery, National Health Insurance Ilsan Hospital, Goyang 10326, KoreaDepartment of Internal Medicine, College of Medicine, Hanyang University, Seoul 04763, KoreaDepartment of Internal Medicine, College of Medicine, Korea University, Seoul 02841, KoreaDepartment of Physical Medicine and Rehabilitation, National Health Insurance Ilsan Hospital, Goyang 10326, Korea<i>Background and objectives: We</i> aimed to analyze factors associated with the period of viral shedding in patients with confirmed COVID-19 who experienced only mild symptoms. <i>Materials and methods:</i> We conducted a multicenter retrospective study from three community treatment centers (CTCs) of South Korea. All patients included were admitted to the three centers before 31 March 2020. We collected data about clinical characteristics and the result of real-time reverse transcription polymerase chain reaction (RT-PCR). <i>Results:</i> Viral shedding was terminated within 32 days and 36 days in 75% and 90% of patients, respectively (range: 8–49 days). The mean period of viral shedding was 23.8 ± 8.7 days. In the multivariate Cox proportional hazards regression analysis, the existence of underlying comorbidities lowered the probability of the termination of viral shedding (HR = 0.561, 95% CI 0.388–0.812). Female sex and presence of COVID-19-associated symptoms also lowered the probability, but the significance was marginal. <i>Conclusions:</i> The existence of underlying comorbidities was associated with delayed termination of viral shedding in COVID-19 patients with mild severity.https://www.mdpi.com/1010-660X/56/12/659COVID-19coronavirusextended care facilitiesisolationRepublic of Korea |
| spellingShingle | Bongyoung Kim Jang Wook Sohn Soomin Nam Jang Won Sohn Won Suk Choi Hyoung Seop Kim Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea Medicina COVID-19 coronavirus extended care facilities isolation Republic of Korea |
| title | Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea |
| title_full | Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea |
| title_fullStr | Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea |
| title_full_unstemmed | Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea |
| title_short | Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea |
| title_sort | factors associated with the delayed termination of viral shedding in covid 19 patients with mild severity in south korea |
| topic | COVID-19 coronavirus extended care facilities isolation Republic of Korea |
| url | https://www.mdpi.com/1010-660X/56/12/659 |
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