Clinical features and histopathological analysis of corneal myxoma
Abstract To describe the presentation, histopathological characteristics, and management outcomes for corneal myxoma. This one-armed cohort study evaluated histologically confirmed consecutive cases of corneal myxoma. Data were evaluated on demographics, clinical presentation, management, histopatho...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15475-1 |
| _version_ | 1811328696257085440 |
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| author | Bader S. Al-Qahtani Hind M. Alkatan Rajiv Khandekar Ahmed Al-Salem Samar A. Al-Swailem |
| author_facet | Bader S. Al-Qahtani Hind M. Alkatan Rajiv Khandekar Ahmed Al-Salem Samar A. Al-Swailem |
| author_sort | Bader S. Al-Qahtani |
| collection | DOAJ |
| description | Abstract To describe the presentation, histopathological characteristics, and management outcomes for corneal myxoma. This one-armed cohort study evaluated histologically confirmed consecutive cases of corneal myxoma. Data were evaluated on demographics, clinical presentation, management, histopathological and immunohistochemical features, and outcomes; visual acuity and corneal clarity. The study sample was comprised of 10 eyes (10 patients). The median age at presentation was 10.5 years. Five eyes had high intraocular pressure, four eyes had decreased distance visual acuity and one eye became discolored. Surgical management included penetrating keratoplasty (8 eyes), phototherapeutic keratectomy (1 eye), and evisceration because of a blind painful eye (1 eye). Postoperative best-corrected distance vision ranged from 20/20 to 20/60 (1 eye), < 20/60 to 20/200 (2 eyes), < 20/200 to 20/400 (1 eye), < 20/200 to light perception (4 eyes) and no light perception (1 eye). The histopathology of these lesions showed typical subepithelial proliferating spindle-shaped cells of mesenchymal origin within a myxoid stroma rich in glycosaminoglycan. The median duration of follow-up was 5 years. Recurrence was observed in an eye that underwent local excision. Corneal myxoma is a rare lesion that is presumably isolated, secondary, and reactive in nature. Surgically management yields reasonably favorable outcomes. |
| first_indexed | 2024-04-13T15:30:43Z |
| format | Article |
| id | doaj.art-213a70d4d15e49509a678179f6c4c6a9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T15:30:43Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-213a70d4d15e49509a678179f6c4c6a92022-12-22T02:41:23ZengNature PortfolioScientific Reports2045-23222022-07-011211910.1038/s41598-022-15475-1Clinical features and histopathological analysis of corneal myxomaBader S. Al-Qahtani0Hind M. Alkatan1Rajiv Khandekar2Ahmed Al-Salem3Samar A. Al-Swailem4Research Department, King Khaled Eye Specialist HospitalOphthalmology Department, College of Medicine, King Saud UniversityResearch Department, King Khaled Eye Specialist HospitalResearch Department, King Khaled Eye Specialist HospitalResearch Department, King Khaled Eye Specialist HospitalAbstract To describe the presentation, histopathological characteristics, and management outcomes for corneal myxoma. This one-armed cohort study evaluated histologically confirmed consecutive cases of corneal myxoma. Data were evaluated on demographics, clinical presentation, management, histopathological and immunohistochemical features, and outcomes; visual acuity and corneal clarity. The study sample was comprised of 10 eyes (10 patients). The median age at presentation was 10.5 years. Five eyes had high intraocular pressure, four eyes had decreased distance visual acuity and one eye became discolored. Surgical management included penetrating keratoplasty (8 eyes), phototherapeutic keratectomy (1 eye), and evisceration because of a blind painful eye (1 eye). Postoperative best-corrected distance vision ranged from 20/20 to 20/60 (1 eye), < 20/60 to 20/200 (2 eyes), < 20/200 to 20/400 (1 eye), < 20/200 to light perception (4 eyes) and no light perception (1 eye). The histopathology of these lesions showed typical subepithelial proliferating spindle-shaped cells of mesenchymal origin within a myxoid stroma rich in glycosaminoglycan. The median duration of follow-up was 5 years. Recurrence was observed in an eye that underwent local excision. Corneal myxoma is a rare lesion that is presumably isolated, secondary, and reactive in nature. Surgically management yields reasonably favorable outcomes.https://doi.org/10.1038/s41598-022-15475-1 |
| spellingShingle | Bader S. Al-Qahtani Hind M. Alkatan Rajiv Khandekar Ahmed Al-Salem Samar A. Al-Swailem Clinical features and histopathological analysis of corneal myxoma Scientific Reports |
| title | Clinical features and histopathological analysis of corneal myxoma |
| title_full | Clinical features and histopathological analysis of corneal myxoma |
| title_fullStr | Clinical features and histopathological analysis of corneal myxoma |
| title_full_unstemmed | Clinical features and histopathological analysis of corneal myxoma |
| title_short | Clinical features and histopathological analysis of corneal myxoma |
| title_sort | clinical features and histopathological analysis of corneal myxoma |
| url | https://doi.org/10.1038/s41598-022-15475-1 |
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