Risk factors for acquiring varicella zoster virus (VZV) infection, and sero-prevalence of anti-VZV immunoglobulin G antibodies in adolescents from a tropical population
<p><strong>Introduction: </strong>Little is known about the sero-prevalence of anti-VZV antibodies among adolescents in the Kandy district of Sri Lanka although adulthood VZV infections are very common in this part of the country.</p><p><strong>Design: </strong...
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| Format: | Article |
| Language: | English |
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Sri Lankan Society for Microbiology
2014-02-01
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| Series: | Sri Lankan Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | https://sljid.sljol.info/articles/5852 |
| _version_ | 1818468496781082624 |
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| author | F Noordeen R Dissanayake IKB Weerasekara PVR Kumarasiri MH Wijedasa |
| author_facet | F Noordeen R Dissanayake IKB Weerasekara PVR Kumarasiri MH Wijedasa |
| author_sort | F Noordeen |
| collection | DOAJ |
| description | <p><strong>Introduction: </strong>Little is known about the sero-prevalence of anti-VZV antibodies among adolescents in the Kandy district of Sri Lanka although adulthood VZV infections are very common in this part of the country.</p><p><strong>Design: </strong>Socio-demographic data and blood samples were collected between November 2004 and April 2005 from a total of 271, 12- to 19-year-old, school students from urban, rural and estate communities. Sera were tested for anti-VZV IgG antibodies using a stranded enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Sero-prevalence of anti-VZV antibodies among the adolescents was found to be 34%. Number of siblings (adolescents without siblings were non-immune; of those with 2 siblings - 27% were immune; of those with more than 2 siblings - 39% were immune) and areas of residence (urban, estate and rural) were significantly associated with the presence of anti-VZV IgG antibodies (<em>p<0.001</em>).</p><p><strong>Conclusions: </strong>Sero-prevalence of anti-VZV IgG<strong> </strong>antibodies was low among adolescents in the Kandy district. Adolescents who lived in the urban areas had a significantly higher rate of anti-VZV IgG<strong> </strong>antibodies than those who lived in rural areas (<em>p<0.001</em>). Adolescents who grow up without siblings are at risk of evading the childhood VZV infection and form a potential target group for adulthood chicken pox.</p><p>DOI: <a href="http://dx.doi.org/10.4038/sljid.v4i1.5852">http://dx.doi.org/10.4038/sljid.v4i1.5852</a></p><p> </p> |
| first_indexed | 2024-04-13T21:13:00Z |
| format | Article |
| id | doaj.art-213c68da35514cb9998c9178ae03f610 |
| institution | Directory Open Access Journal |
| issn | 2012-8169 2448-9654 |
| language | English |
| last_indexed | 2024-04-13T21:13:00Z |
| publishDate | 2014-02-01 |
| publisher | Sri Lankan Society for Microbiology |
| record_format | Article |
| series | Sri Lankan Journal of Infectious Diseases |
| spelling | doaj.art-213c68da35514cb9998c9178ae03f6102022-12-22T02:29:47ZengSri Lankan Society for MicrobiologySri Lankan Journal of Infectious Diseases2012-81692448-96542014-02-0141303710.4038/sljid.v4i1.58525127Risk factors for acquiring varicella zoster virus (VZV) infection, and sero-prevalence of anti-VZV immunoglobulin G antibodies in adolescents from a tropical populationF Noordeen0R Dissanayake1IKB Weerasekara2PVR Kumarasiri3MH Wijedasa4Faculty of Medicine, University of PeradeniyaDepartment of Microbiology, Faculty of Medicine, University of PeradeniyaDepartment of Microbiology, Faculty of Medicine, University of PeradeniyaDepartment of Community Medicine, Faculty of Medicine, University of PeradeniyaDepartment of Microbiology, Faculty of Medicine, University of Peradeniya<p><strong>Introduction: </strong>Little is known about the sero-prevalence of anti-VZV antibodies among adolescents in the Kandy district of Sri Lanka although adulthood VZV infections are very common in this part of the country.</p><p><strong>Design: </strong>Socio-demographic data and blood samples were collected between November 2004 and April 2005 from a total of 271, 12- to 19-year-old, school students from urban, rural and estate communities. Sera were tested for anti-VZV IgG antibodies using a stranded enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Sero-prevalence of anti-VZV antibodies among the adolescents was found to be 34%. Number of siblings (adolescents without siblings were non-immune; of those with 2 siblings - 27% were immune; of those with more than 2 siblings - 39% were immune) and areas of residence (urban, estate and rural) were significantly associated with the presence of anti-VZV IgG antibodies (<em>p<0.001</em>).</p><p><strong>Conclusions: </strong>Sero-prevalence of anti-VZV IgG<strong> </strong>antibodies was low among adolescents in the Kandy district. Adolescents who lived in the urban areas had a significantly higher rate of anti-VZV IgG<strong> </strong>antibodies than those who lived in rural areas (<em>p<0.001</em>). Adolescents who grow up without siblings are at risk of evading the childhood VZV infection and form a potential target group for adulthood chicken pox.</p><p>DOI: <a href="http://dx.doi.org/10.4038/sljid.v4i1.5852">http://dx.doi.org/10.4038/sljid.v4i1.5852</a></p><p> </p>https://sljid.sljol.info/articles/5852varicellaadolescentsseroprevalencesri lankatropical countries |
| spellingShingle | F Noordeen R Dissanayake IKB Weerasekara PVR Kumarasiri MH Wijedasa Risk factors for acquiring varicella zoster virus (VZV) infection, and sero-prevalence of anti-VZV immunoglobulin G antibodies in adolescents from a tropical population Sri Lankan Journal of Infectious Diseases varicella adolescents seroprevalence sri lanka tropical countries |
| title | Risk factors for acquiring varicella zoster virus (VZV) infection, and sero-prevalence of anti-VZV immunoglobulin G antibodies in adolescents from a tropical population |
| title_full | Risk factors for acquiring varicella zoster virus (VZV) infection, and sero-prevalence of anti-VZV immunoglobulin G antibodies in adolescents from a tropical population |
| title_fullStr | Risk factors for acquiring varicella zoster virus (VZV) infection, and sero-prevalence of anti-VZV immunoglobulin G antibodies in adolescents from a tropical population |
| title_full_unstemmed | Risk factors for acquiring varicella zoster virus (VZV) infection, and sero-prevalence of anti-VZV immunoglobulin G antibodies in adolescents from a tropical population |
| title_short | Risk factors for acquiring varicella zoster virus (VZV) infection, and sero-prevalence of anti-VZV immunoglobulin G antibodies in adolescents from a tropical population |
| title_sort | risk factors for acquiring varicella zoster virus vzv infection and sero prevalence of anti vzv immunoglobulin g antibodies in adolescents from a tropical population |
| topic | varicella adolescents seroprevalence sri lanka tropical countries |
| url | https://sljid.sljol.info/articles/5852 |
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