<i>Lactobacillus reuteri</i> CCFM8631 Alleviates Hypercholesterolaemia Caused by the Paigen Atherogenic Diet by Regulating the Gut Microbiota
Cardiovascular disease has one of the highest global incidences and mortality rates. Atherosclerosis is the main cause of cardiovascular disease, and hypercholesterolaemia and hyperlipidaemia are the main risk factors for the development of atherosclerosis. Decreasing serum cholesterol and triglycer...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/6/1272 |
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| author | Qianqian Wang Yufeng He Xiu Li Ting Zhang Ming Liang Gang Wang Jianxin Zhao Hao Zhang Wei Chen |
| author_facet | Qianqian Wang Yufeng He Xiu Li Ting Zhang Ming Liang Gang Wang Jianxin Zhao Hao Zhang Wei Chen |
| author_sort | Qianqian Wang |
| collection | DOAJ |
| description | Cardiovascular disease has one of the highest global incidences and mortality rates. Atherosclerosis is the main cause of cardiovascular disease, and hypercholesterolaemia and hyperlipidaemia are the main risk factors for the development of atherosclerosis. Decreasing serum cholesterol and triglyceride concentrations is considered to be an effective strategy to prevent atherosclerotic cardiovascular disease. Previous studies have shown that many diseases are related to gut microbiota dysbiosis. The positive regulation of the gut microbiota by probiotics may prevent or treat certain diseases. In this study, <i>Lactobacillus reuteri</i> CCFM8631 treatment was shown to decrease plasma total cholesterol (TC), low-density lipoprotein–cholesterol, aspartate transaminase, alanine transaminase and trimethylamine N-oxide concentrations, decrease liver TC and malondialdehyde concentrations and recover liver superoxide dismutase concentrations in mice fed a Paigen atherogenic diet. In addition, <i>L. reuteri</i> increased the faecal short-chain fatty acid content (acetate, propionate and butyrate), which was accompanied by an increase in the relative abundance of faecal Deferribacteres, <i>Lachnospiraceae</i> NK4A136 group, <i>Lactobacillus</i> and <i>Dubosiella</i>; a decrease in the relative abundance of <i>Erysipelatoclostridium</i> and <i>Romboutsia</i> and the activation of butanoate and vitamin B6 metabolism, leading to the alleviation of hypercholesterolaemia. |
| first_indexed | 2024-03-09T13:04:28Z |
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| id | doaj.art-213d5192ba9e4d67ad8fd31a737fb10d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T13:04:28Z |
| publishDate | 2022-03-01 |
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| series | Nutrients |
| spelling | doaj.art-213d5192ba9e4d67ad8fd31a737fb10d2023-11-30T21:50:29ZengMDPI AGNutrients2072-66432022-03-01146127210.3390/nu14061272<i>Lactobacillus reuteri</i> CCFM8631 Alleviates Hypercholesterolaemia Caused by the Paigen Atherogenic Diet by Regulating the Gut MicrobiotaQianqian Wang0Yufeng He1Xiu Li2Ting Zhang3Ming Liang4Gang Wang5Jianxin Zhao6Hao Zhang7Wei Chen8State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaInfinitus (China) Company Ltd., Guangzhou 510645, ChinaInfinitus (China) Company Ltd., Guangzhou 510645, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaCardiovascular disease has one of the highest global incidences and mortality rates. Atherosclerosis is the main cause of cardiovascular disease, and hypercholesterolaemia and hyperlipidaemia are the main risk factors for the development of atherosclerosis. Decreasing serum cholesterol and triglyceride concentrations is considered to be an effective strategy to prevent atherosclerotic cardiovascular disease. Previous studies have shown that many diseases are related to gut microbiota dysbiosis. The positive regulation of the gut microbiota by probiotics may prevent or treat certain diseases. In this study, <i>Lactobacillus reuteri</i> CCFM8631 treatment was shown to decrease plasma total cholesterol (TC), low-density lipoprotein–cholesterol, aspartate transaminase, alanine transaminase and trimethylamine N-oxide concentrations, decrease liver TC and malondialdehyde concentrations and recover liver superoxide dismutase concentrations in mice fed a Paigen atherogenic diet. In addition, <i>L. reuteri</i> increased the faecal short-chain fatty acid content (acetate, propionate and butyrate), which was accompanied by an increase in the relative abundance of faecal Deferribacteres, <i>Lachnospiraceae</i> NK4A136 group, <i>Lactobacillus</i> and <i>Dubosiella</i>; a decrease in the relative abundance of <i>Erysipelatoclostridium</i> and <i>Romboutsia</i> and the activation of butanoate and vitamin B6 metabolism, leading to the alleviation of hypercholesterolaemia.https://www.mdpi.com/2072-6643/14/6/1272atherosclerosisgut microbiotaprobioticsshort chain fatty acidshypercholesterolaemia |
| spellingShingle | Qianqian Wang Yufeng He Xiu Li Ting Zhang Ming Liang Gang Wang Jianxin Zhao Hao Zhang Wei Chen <i>Lactobacillus reuteri</i> CCFM8631 Alleviates Hypercholesterolaemia Caused by the Paigen Atherogenic Diet by Regulating the Gut Microbiota Nutrients atherosclerosis gut microbiota probiotics short chain fatty acids hypercholesterolaemia |
| title | <i>Lactobacillus reuteri</i> CCFM8631 Alleviates Hypercholesterolaemia Caused by the Paigen Atherogenic Diet by Regulating the Gut Microbiota |
| title_full | <i>Lactobacillus reuteri</i> CCFM8631 Alleviates Hypercholesterolaemia Caused by the Paigen Atherogenic Diet by Regulating the Gut Microbiota |
| title_fullStr | <i>Lactobacillus reuteri</i> CCFM8631 Alleviates Hypercholesterolaemia Caused by the Paigen Atherogenic Diet by Regulating the Gut Microbiota |
| title_full_unstemmed | <i>Lactobacillus reuteri</i> CCFM8631 Alleviates Hypercholesterolaemia Caused by the Paigen Atherogenic Diet by Regulating the Gut Microbiota |
| title_short | <i>Lactobacillus reuteri</i> CCFM8631 Alleviates Hypercholesterolaemia Caused by the Paigen Atherogenic Diet by Regulating the Gut Microbiota |
| title_sort | i lactobacillus reuteri i ccfm8631 alleviates hypercholesterolaemia caused by the paigen atherogenic diet by regulating the gut microbiota |
| topic | atherosclerosis gut microbiota probiotics short chain fatty acids hypercholesterolaemia |
| url | https://www.mdpi.com/2072-6643/14/6/1272 |
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