Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium

Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium

Abstract Background Genetic disruption of slc4a10, which encodes the sodium-dependent chloride/bicarbonate exchanger Ncbe, leads to a major decrease in Na+-dependent HCO3 − import into choroid plexus epithelial cells in mice and to a marked reduction in brain intraventricular fluid volume. This sugg...

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Bibliographic Details
Main Authors: Inga Baasch Christensen, Qi Wu, Anders Solitander Bohlbro, Marianne Gerberg Skals, Helle Hasager Damkier, Christian Andreas Hübner, Robert Andrew Fenton, Jeppe Praetorius
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Fluids and Barriers of the CNS
Subjects:
Choroid plexus
Cerebrospinal fluid
Ncbe
Mass spectrometry
Online Access:https://doi.org/10.1186/s12987-019-0162-5

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