Non‐small cell lung cancer with tumor proportion score > 90% could increase the risk of severe immune‐related adverse events in first‐line treatments with immune checkpoint inhibitors: A retrospective single‐center study
Abstract Background Since 2015, immune checkpoint inhibitors have been a clinical treatment strategy for patients with advanced or recurrent non‐small cell lung cancer (NSCLC). However, the relationship between immune‐related adverse event (irAE) risk factors and patient clinical characteristics is...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14576 |
| _version_ | 1811186796694863872 |
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| author | Yuki Akazawa Aki Yoshikawa Masaki Kanazu Yukihiro Yano Toshihiko Yamaguchi Masahide Mori |
| author_facet | Yuki Akazawa Aki Yoshikawa Masaki Kanazu Yukihiro Yano Toshihiko Yamaguchi Masahide Mori |
| author_sort | Yuki Akazawa |
| collection | DOAJ |
| description | Abstract Background Since 2015, immune checkpoint inhibitors have been a clinical treatment strategy for patients with advanced or recurrent non‐small cell lung cancer (NSCLC). However, the relationship between immune‐related adverse event (irAE) risk factors and patient clinical characteristics is unclear. This study aimed to evaluate the relationship between irAE risk and the clinical characteristics of patients with NSCLC. Methods We included patients with advanced or recurrent NSCLC with known programmed death‐ligand 1 expression levels treated with immune checkpoint inhibitors. We retrospectively examined the medical records of 260 patients with NSCLC (March 2016–November 2020) and analyzed the relationship between the patient clinical characteristics and irAEs. Results Our retrospective analysis revealed that tumor proportion score (TPS) ≥ 90% and adenocarcinoma histology were independent risk factors for irAEs (odds ratio: 3.750 95% confidence interval [CI]: 1.58–8.89 and 0.424 95% CI: 0.19–0.97, respectively) in first‐line treatment. However, in patients receiving second‐ or later‐line treatments, no clinical characteristics were identified as risk factors for irAEs. Furthermore, no difference was observed in the response rates to first‐line treatments between the TPS ≥ 90% and TPS < 90% groups (74% vs. 71%, p = 0.83). In later‐line treatments, the TPS ≥ 90% group had a better response rate than the TPS < 90% group (55% vs. 17%, p < 0.05). However, no significant differences in overall survival were observed in either of the groups. Conclusions TPS ≥ 90% and adenocarcinoma histology were independent risk factors for irAEs in previously untreated patients with advanced or recurrent NSCLC. Therefore, patients at high risk of irAEs require additional monitoring. |
| first_indexed | 2024-04-11T13:52:27Z |
| format | Article |
| id | doaj.art-213e6379857b4fbea92817af79621d96 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-11T13:52:27Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-213e6379857b4fbea92817af79621d962022-12-22T04:20:31ZengWileyThoracic Cancer1759-77061759-77142022-09-0113172450245810.1111/1759-7714.14576Non‐small cell lung cancer with tumor proportion score > 90% could increase the risk of severe immune‐related adverse events in first‐line treatments with immune checkpoint inhibitors: A retrospective single‐center studyYuki Akazawa0Aki Yoshikawa1Masaki Kanazu2Yukihiro Yano3Toshihiko Yamaguchi4Masahide Mori5Department of Thoracic Oncology National Hospital Organization Osaka Toneyama Medical Center Toyonaka City JapanDepartment of Thoracic Oncology National Hospital Organization Osaka Toneyama Medical Center Toyonaka City JapanDepartment of Thoracic Oncology National Hospital Organization Osaka Toneyama Medical Center Toyonaka City JapanDepartment of Thoracic Oncology National Hospital Organization Osaka Toneyama Medical Center Toyonaka City JapanDepartment of Thoracic Oncology National Hospital Organization Osaka Toneyama Medical Center Toyonaka City JapanDepartment of Thoracic Oncology National Hospital Organization Osaka Toneyama Medical Center Toyonaka City JapanAbstract Background Since 2015, immune checkpoint inhibitors have been a clinical treatment strategy for patients with advanced or recurrent non‐small cell lung cancer (NSCLC). However, the relationship between immune‐related adverse event (irAE) risk factors and patient clinical characteristics is unclear. This study aimed to evaluate the relationship between irAE risk and the clinical characteristics of patients with NSCLC. Methods We included patients with advanced or recurrent NSCLC with known programmed death‐ligand 1 expression levels treated with immune checkpoint inhibitors. We retrospectively examined the medical records of 260 patients with NSCLC (March 2016–November 2020) and analyzed the relationship between the patient clinical characteristics and irAEs. Results Our retrospective analysis revealed that tumor proportion score (TPS) ≥ 90% and adenocarcinoma histology were independent risk factors for irAEs (odds ratio: 3.750 95% confidence interval [CI]: 1.58–8.89 and 0.424 95% CI: 0.19–0.97, respectively) in first‐line treatment. However, in patients receiving second‐ or later‐line treatments, no clinical characteristics were identified as risk factors for irAEs. Furthermore, no difference was observed in the response rates to first‐line treatments between the TPS ≥ 90% and TPS < 90% groups (74% vs. 71%, p = 0.83). In later‐line treatments, the TPS ≥ 90% group had a better response rate than the TPS < 90% group (55% vs. 17%, p < 0.05). However, no significant differences in overall survival were observed in either of the groups. Conclusions TPS ≥ 90% and adenocarcinoma histology were independent risk factors for irAEs in previously untreated patients with advanced or recurrent NSCLC. Therefore, patients at high risk of irAEs require additional monitoring.https://doi.org/10.1111/1759-7714.14576adenocarcinomaimmune checkpoint inhibitorimmune‐related adverse eventnon‐small cell lung cancer |
| spellingShingle | Yuki Akazawa Aki Yoshikawa Masaki Kanazu Yukihiro Yano Toshihiko Yamaguchi Masahide Mori Non‐small cell lung cancer with tumor proportion score > 90% could increase the risk of severe immune‐related adverse events in first‐line treatments with immune checkpoint inhibitors: A retrospective single‐center study Thoracic Cancer adenocarcinoma immune checkpoint inhibitor immune‐related adverse event non‐small cell lung cancer |
| title | Non‐small cell lung cancer with tumor proportion score > 90% could increase the risk of severe immune‐related adverse events in first‐line treatments with immune checkpoint inhibitors: A retrospective single‐center study |
| title_full | Non‐small cell lung cancer with tumor proportion score > 90% could increase the risk of severe immune‐related adverse events in first‐line treatments with immune checkpoint inhibitors: A retrospective single‐center study |
| title_fullStr | Non‐small cell lung cancer with tumor proportion score > 90% could increase the risk of severe immune‐related adverse events in first‐line treatments with immune checkpoint inhibitors: A retrospective single‐center study |
| title_full_unstemmed | Non‐small cell lung cancer with tumor proportion score > 90% could increase the risk of severe immune‐related adverse events in first‐line treatments with immune checkpoint inhibitors: A retrospective single‐center study |
| title_short | Non‐small cell lung cancer with tumor proportion score > 90% could increase the risk of severe immune‐related adverse events in first‐line treatments with immune checkpoint inhibitors: A retrospective single‐center study |
| title_sort | non small cell lung cancer with tumor proportion score 90 could increase the risk of severe immune related adverse events in first line treatments with immune checkpoint inhibitors a retrospective single center study |
| topic | adenocarcinoma immune checkpoint inhibitor immune‐related adverse event non‐small cell lung cancer |
| url | https://doi.org/10.1111/1759-7714.14576 |
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