The Role of miRNAs in Immune Cell Development, Immune Cell Activation, and Tumor Immunity: With a Focus on Macrophages and Natural Killer Cells
The tumor microenvironment (TME) is the primary arena where tumor cells and the host immune system interact. Bidirectional communication between tumor cells and the associated stromal cell types within the TME influences disease initiation and progression, as well as tumor immunity. Macrophages and...
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MDPI AG
2019-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/10/1140 |
| _version_ | 1827837070435942400 |
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| author | Shi Jun Xu Hong Tao Hu Hai Liang Li Suhwan Chang |
| author_facet | Shi Jun Xu Hong Tao Hu Hai Liang Li Suhwan Chang |
| author_sort | Shi Jun Xu |
| collection | DOAJ |
| description | The tumor microenvironment (TME) is the primary arena where tumor cells and the host immune system interact. Bidirectional communication between tumor cells and the associated stromal cell types within the TME influences disease initiation and progression, as well as tumor immunity. Macrophages and natural killer (NK) cells are crucial components of the stromal compartment and display either pro- or anti-tumor properties, depending on the expression of key regulators. MicroRNAs (miRNAs) are emerging as such regulators. They affect several immune cell functions closely related to tumor evasion of the immune system. This review discusses the role of miRNAs in the differentiation, maturation, and activation of immune cells as well as tumor immunity, focusing particularly on macrophages and NK cells. |
| first_indexed | 2024-03-12T06:36:48Z |
| format | Article |
| id | doaj.art-213f86c7137e42c6a9ed0ce10a077ec6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:36:48Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-213f86c7137e42c6a9ed0ce10a077ec62023-09-03T01:13:49ZengMDPI AGCells2073-44092019-09-01810114010.3390/cells8101140cells8101140The Role of miRNAs in Immune Cell Development, Immune Cell Activation, and Tumor Immunity: With a Focus on Macrophages and Natural Killer CellsShi Jun Xu0Hong Tao Hu1Hai Liang Li2Suhwan Chang3Department of Radiology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, ChinaDepartment of Minimal Invasive Intervention, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, ChinaDepartment of Radiology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, ChinaDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Seoul 05505, KoreaThe tumor microenvironment (TME) is the primary arena where tumor cells and the host immune system interact. Bidirectional communication between tumor cells and the associated stromal cell types within the TME influences disease initiation and progression, as well as tumor immunity. Macrophages and natural killer (NK) cells are crucial components of the stromal compartment and display either pro- or anti-tumor properties, depending on the expression of key regulators. MicroRNAs (miRNAs) are emerging as such regulators. They affect several immune cell functions closely related to tumor evasion of the immune system. This review discusses the role of miRNAs in the differentiation, maturation, and activation of immune cells as well as tumor immunity, focusing particularly on macrophages and NK cells.https://www.mdpi.com/2073-4409/8/10/1140miRNAtumor immunitymacrophagesnatural killer cells |
| spellingShingle | Shi Jun Xu Hong Tao Hu Hai Liang Li Suhwan Chang The Role of miRNAs in Immune Cell Development, Immune Cell Activation, and Tumor Immunity: With a Focus on Macrophages and Natural Killer Cells Cells miRNA tumor immunity macrophages natural killer cells |
| title | The Role of miRNAs in Immune Cell Development, Immune Cell Activation, and Tumor Immunity: With a Focus on Macrophages and Natural Killer Cells |
| title_full | The Role of miRNAs in Immune Cell Development, Immune Cell Activation, and Tumor Immunity: With a Focus on Macrophages and Natural Killer Cells |
| title_fullStr | The Role of miRNAs in Immune Cell Development, Immune Cell Activation, and Tumor Immunity: With a Focus on Macrophages and Natural Killer Cells |
| title_full_unstemmed | The Role of miRNAs in Immune Cell Development, Immune Cell Activation, and Tumor Immunity: With a Focus on Macrophages and Natural Killer Cells |
| title_short | The Role of miRNAs in Immune Cell Development, Immune Cell Activation, and Tumor Immunity: With a Focus on Macrophages and Natural Killer Cells |
| title_sort | role of mirnas in immune cell development immune cell activation and tumor immunity with a focus on macrophages and natural killer cells |
| topic | miRNA tumor immunity macrophages natural killer cells |
| url | https://www.mdpi.com/2073-4409/8/10/1140 |
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