Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome
Background: Primary Sjögren's syndrome (pSS) is a disease associated with the overexpression of proinflammatory cytokines, and oxidative stress is one of the factors responsible for its etiopathogenesis. This study aimed to investigate the thiol/disulphide homeostasis in pSS patients. Methods:...
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Society of Medical Biochemists of Serbia, Belgrade
2021-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2021/1452-82582103270Y.pdf |
| _version_ | 1818658384060088320 |
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| author | Yilmaz Cakmak Nuray Gemcioglu Emin Baser Salih Erten Sükran Erel Ozcan |
| author_facet | Yilmaz Cakmak Nuray Gemcioglu Emin Baser Salih Erten Sükran Erel Ozcan |
| author_sort | Yilmaz Cakmak Nuray |
| collection | DOAJ |
| description | Background: Primary Sjögren's syndrome (pSS) is a disease associated with the overexpression of proinflammatory cytokines, and oxidative stress is one of the factors responsible for its etiopathogenesis. This study aimed to investigate the thiol/disulphide homeostasis in pSS patients. Methods: The study included 68 pSS patients and 69 healthy controls. Thiol/disulphide homeostasis (total thiol, native thiol, and disulphide levels) was measured using the automatic spectrophotometric method developed by Erel and Neselioglu, and the results of the 2 groups were compared. Results: The gender and age distributions of the pSS and control groups were similar (P = 0.988 and P = 0.065). Total thiol and native thiol levels were lower in the pSS group than in the control group (470.08 ± 33.65 mmol/L vs. 528.21 ± 44.99 mmol/L, P < 0.001, and 439.14 ± 30.67 mmol/L vs. 497.56 ± 46.70 mmol/L, P < 0.001, respectively). There were no differences in disulphide levels between groups 17.00 (range 0.70-217.0) mmol/L vs. 14.95 (range 2.10-40.10) mmol/L, P = 0.195. Conclusions: It was concluded that the thiol/disulphide balance shifted towards disulphide in patients with pSS. |
| first_indexed | 2024-12-17T03:56:31Z |
| format | Article |
| id | doaj.art-2140a267702e45f3ae7d888b0b615e75 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-17T03:56:31Z |
| publishDate | 2021-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-2140a267702e45f3ae7d888b0b615e752022-12-21T22:04:37ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662021-01-0140327027610.5937/jomb0-272811452-82582103270YThiol/disulfide homeostasis impaired in patients with primary Sjögren's syndromeYilmaz Cakmak Nuray0Gemcioglu Emin1Baser Salih2Erten Sükran3Erel Ozcan4Ankara City Hospital, Department of Internal Medicine, Ankara, TurkeyAnkara City Hospital, Department of Internal Medicine, Ankara, TurkeyYıldırım Beyazıt University, Ankara City Hospital, Department of Internal Medicine, Ankara, TurkeyYıldırım Beyazıt University, Ankara City Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, TurkeyYıldırım Beyazıt University, Ankara City Hospital, Department of Biochemistry, Ankara, TurkeyBackground: Primary Sjögren's syndrome (pSS) is a disease associated with the overexpression of proinflammatory cytokines, and oxidative stress is one of the factors responsible for its etiopathogenesis. This study aimed to investigate the thiol/disulphide homeostasis in pSS patients. Methods: The study included 68 pSS patients and 69 healthy controls. Thiol/disulphide homeostasis (total thiol, native thiol, and disulphide levels) was measured using the automatic spectrophotometric method developed by Erel and Neselioglu, and the results of the 2 groups were compared. Results: The gender and age distributions of the pSS and control groups were similar (P = 0.988 and P = 0.065). Total thiol and native thiol levels were lower in the pSS group than in the control group (470.08 ± 33.65 mmol/L vs. 528.21 ± 44.99 mmol/L, P < 0.001, and 439.14 ± 30.67 mmol/L vs. 497.56 ± 46.70 mmol/L, P < 0.001, respectively). There were no differences in disulphide levels between groups 17.00 (range 0.70-217.0) mmol/L vs. 14.95 (range 2.10-40.10) mmol/L, P = 0.195. Conclusions: It was concluded that the thiol/disulphide balance shifted towards disulphide in patients with pSS.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2021/1452-82582103270Y.pdfprimary sjögren's syndromeoxidative stressthiol/disulphide homeostasis |
| spellingShingle | Yilmaz Cakmak Nuray Gemcioglu Emin Baser Salih Erten Sükran Erel Ozcan Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome Journal of Medical Biochemistry primary sjögren's syndrome oxidative stress thiol/disulphide homeostasis |
| title | Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome |
| title_full | Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome |
| title_fullStr | Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome |
| title_full_unstemmed | Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome |
| title_short | Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome |
| title_sort | thiol disulfide homeostasis impaired in patients with primary sjogren s syndrome |
| topic | primary sjögren's syndrome oxidative stress thiol/disulphide homeostasis |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2021/1452-82582103270Y.pdf |
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