Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing
Background This study aimed to evaluate the co-administration effect of atelocollagen combined with hyaluronic acid (HA) injections for treatment of full-thickness rotator cuff tear (RCT). Methods Eighty patients who underwent arthroscopic rotator cuff repair for full-thickness RCT from March 2018 t...
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| Format: | Article |
| Language: | English |
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Korean Shoulder and Elbow Society
2021-09-01
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| Series: | Clinics in Shoulder and Elbow |
| Subjects: | |
| Online Access: | http://www.cisejournal.org/upload/pdf/cise-2021-00234.pdf |
| _version_ | 1797334255559245824 |
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| author | Jeung Yeol Jeong Eun Kyung Khil Tae Soung Kim Young Woo Kim |
| author_facet | Jeung Yeol Jeong Eun Kyung Khil Tae Soung Kim Young Woo Kim |
| author_sort | Jeung Yeol Jeong |
| collection | DOAJ |
| description | Background This study aimed to evaluate the co-administration effect of atelocollagen combined with hyaluronic acid (HA) injections for treatment of full-thickness rotator cuff tear (RCT). Methods Eighty patients who underwent arthroscopic rotator cuff repair for full-thickness RCT from March 2018 to November 2019 were enrolled. The patients were randomly allocated to the following groups: combined atelocollagen and HA injection (group I, n=28), only HA injection (group II, n=26), and no injection (group III, n=26). Clinical outcomes were assessed at 3, 6, and 12 months after surgery using the American Shoulder and Elbow Surgeons score, visual analog scale pain score , functional scores (pain visual analog scale, function visual analog score), and range of motion. Magnetic resonance imaging was performed 12 months after surgery to evaluate rotator cuff integrity. Results Preoperative demographic data and postoperative clinical outcomes did not differ significantly among the three groups (p>0.05). However, in group I, the number of steroid injections after surgery was significantly lower than that in the other groups (p=0.011). The retear rate on follow-up magnetic resonance imaging was significantly higher in group II (9.5%, n=2) and group III (13.6%, n=3) than in group I (0%) (p=0.021). Conclusions Co-administration of atelocollagen and HA improves healing of the rotator cuff and increases the integrity of the rotator cuff repair site. This study provides encouraging evidence for use of combined atelocollagen-HA injections to treat patients with full-thickness RCT. |
| first_indexed | 2024-03-08T08:17:04Z |
| format | Article |
| id | doaj.art-2141a5e7055f4a7493776d27beb6dbed |
| institution | Directory Open Access Journal |
| issn | 2288-8721 |
| language | English |
| last_indexed | 2024-03-08T08:17:04Z |
| publishDate | 2021-09-01 |
| publisher | Korean Shoulder and Elbow Society |
| record_format | Article |
| series | Clinics in Shoulder and Elbow |
| spelling | doaj.art-2141a5e7055f4a7493776d27beb6dbed2024-02-02T07:00:06ZengKorean Shoulder and Elbow SocietyClinics in Shoulder and Elbow2288-87212021-09-0124314715510.5397/cise.2021.00234810Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healingJeung Yeol Jeong0Eun Kyung Khil1Tae Soung Kim2Young Woo Kim3 Department of Orthopedic Surgery, Hallym University Dongtan Sacred Heart Hospital, Medical College of Hallym University, Hwaseong, Korea Department of Radiology, Hallym University Dongtan Sacred Heart Hospital, Medical College of Hallym University, Hwaseong, Korea Department of Orthopedic Surgery, Hallym University Dongtan Sacred Heart Hospital, Medical College of Hallym University, Hwaseong, Korea Department of Orthopedic Surgery, Hallym University Dongtan Sacred Heart Hospital, Medical College of Hallym University, Hwaseong, KoreaBackground This study aimed to evaluate the co-administration effect of atelocollagen combined with hyaluronic acid (HA) injections for treatment of full-thickness rotator cuff tear (RCT). Methods Eighty patients who underwent arthroscopic rotator cuff repair for full-thickness RCT from March 2018 to November 2019 were enrolled. The patients were randomly allocated to the following groups: combined atelocollagen and HA injection (group I, n=28), only HA injection (group II, n=26), and no injection (group III, n=26). Clinical outcomes were assessed at 3, 6, and 12 months after surgery using the American Shoulder and Elbow Surgeons score, visual analog scale pain score , functional scores (pain visual analog scale, function visual analog score), and range of motion. Magnetic resonance imaging was performed 12 months after surgery to evaluate rotator cuff integrity. Results Preoperative demographic data and postoperative clinical outcomes did not differ significantly among the three groups (p>0.05). However, in group I, the number of steroid injections after surgery was significantly lower than that in the other groups (p=0.011). The retear rate on follow-up magnetic resonance imaging was significantly higher in group II (9.5%, n=2) and group III (13.6%, n=3) than in group I (0%) (p=0.021). Conclusions Co-administration of atelocollagen and HA improves healing of the rotator cuff and increases the integrity of the rotator cuff repair site. This study provides encouraging evidence for use of combined atelocollagen-HA injections to treat patients with full-thickness RCT.http://www.cisejournal.org/upload/pdf/cise-2021-00234.pdfshoulderrotator cufffull-thickness tearatelocollagenhyaluronic acid |
| spellingShingle | Jeung Yeol Jeong Eun Kyung Khil Tae Soung Kim Young Woo Kim Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing Clinics in Shoulder and Elbow shoulder rotator cuff full-thickness tear atelocollagen hyaluronic acid |
| title | Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing |
| title_full | Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing |
| title_fullStr | Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing |
| title_full_unstemmed | Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing |
| title_short | Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing |
| title_sort | effect of co administration of atelocollagen and hyaluronic acid on rotator cuff healing |
| topic | shoulder rotator cuff full-thickness tear atelocollagen hyaluronic acid |
| url | http://www.cisejournal.org/upload/pdf/cise-2021-00234.pdf |
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