Complex Perinatal Syndromes Affecting Early Human Growth and Development: Issues to Consider to Understand Their Aetiology and Postnatal Effects
Complex perinatal syndromes (CPS) affecting pregnancy and childhood, such as preterm birth, and intra- and extra-uterine growth restriction, have multiple, diverse contexts of complexity and interaction that determine the short- and long-term growth, health and development of all human beings. Early...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.856886/full |
| _version_ | 1818271888198074368 |
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| author | Roberto Frenquelli Marc Ratcliff Jimena Villar de Onis Jimena Villar de Onis Michelle Fernandes Michelle Fernandes Michelle Fernandes Fernando C. Barros Jane E. Hirst Aris T. Papageorghiou Aris T. Papageorghiou Stephen H. Kennedy Stephen H. Kennedy Jose Villar Jose Villar |
| author_facet | Roberto Frenquelli Marc Ratcliff Jimena Villar de Onis Jimena Villar de Onis Michelle Fernandes Michelle Fernandes Michelle Fernandes Fernando C. Barros Jane E. Hirst Aris T. Papageorghiou Aris T. Papageorghiou Stephen H. Kennedy Stephen H. Kennedy Jose Villar Jose Villar |
| author_sort | Roberto Frenquelli |
| collection | DOAJ |
| description | Complex perinatal syndromes (CPS) affecting pregnancy and childhood, such as preterm birth, and intra- and extra-uterine growth restriction, have multiple, diverse contexts of complexity and interaction that determine the short- and long-term growth, health and development of all human beings. Early in life, genetically-guided somatic and cerebral development occurs alongside a psychism “in statu nascendi,” with the neural structures subjected to the effects of the intra- and extra-uterine environments in preparation for optimal postnatal functioning. Different trajectories of fetal cranial and abdominal growth have been identified before 25 weeks’ gestation, tracking differential growth and neurodevelopment at 2 years of age. Similarly, critical time-windows exist in the first 5–8 months of postnatal life because of interactions between the newborn and their environment, mother/care-givers and feeding practices. Understanding these complex relational processes requires abandoning classical, linear and mechanistic interpretations that are placed in rigid, artificial biological silos. Instead, we need to conduct longitudinal, interdisciplinary research and integrate the resulting new knowledge into clinical practice. An ecological-systemic approach is required to understand early human growth and development, based on a dynamic multidimensional process from the molecular or genomic level to the socio-economic-environmental context. For this, we need theoretical and methodological tools that permit a global understanding of CPS, delineating temporal trajectories and their conditioning factors, updated by the incorporation of new scientific discoveries. The potential to optimize human growth and development across chronological age and geographical locations – by implementing interventions or “treatments” during periods of greatest instability or vulnerability – should be recognized. Hence, it is imperative to take a holistic view of reproductive and perinatal issues, acknowledging at all levels the complexity and interactions of CPS and their sensitive periods, laying the foundations for further improvements in growth and development of populations, to maximize global human potential. We discuss here conceptual issues that should be considered for the development and implementation of such a strategy aimed at addressing the perinatal health problems of the new millenium. |
| first_indexed | 2024-12-12T21:33:19Z |
| format | Article |
| id | doaj.art-214427540d2f43f688cda8214e13096e |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T21:33:19Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-214427540d2f43f688cda8214e13096e2022-12-22T00:11:15ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-04-011610.3389/fnins.2022.856886856886Complex Perinatal Syndromes Affecting Early Human Growth and Development: Issues to Consider to Understand Their Aetiology and Postnatal EffectsRoberto Frenquelli0Marc Ratcliff1Jimena Villar de Onis2Jimena Villar de Onis3Michelle Fernandes4Michelle Fernandes5Michelle Fernandes6Fernando C. Barros7Jane E. Hirst8Aris T. Papageorghiou9Aris T. Papageorghiou10Stephen H. Kennedy11Stephen H. Kennedy12Jose Villar13Jose Villar14Master Program in Child Psychoanalysis and Neuropsychological, Developmental Psychology Unit, Faculty of Psychology, National University of Rosario, Rosario, ArgentinaFaculty of Psychology and Educational Science, Centre Jean Piaget, University of Geneva, Geneva, SwitzerlandOxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United KingdomGeneva Foundation for Medical Education and Research, Geneva, SwitzerlandOxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United KingdomMRC Lifecourse Epidemiology Centre, Human Development and Health Academic Unit, Department of Paediatrics, Faculty of Medicine, University of Southampton, Southampton, United KingdomNuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, United KingdomPost Graduate Course on Health in the Vital Cycle, Universidade Católica de Pelotas, Pelotas, BrazilNuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, United KingdomOxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United KingdomNuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, United KingdomOxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United KingdomNuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, United KingdomOxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United KingdomNuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, United KingdomComplex perinatal syndromes (CPS) affecting pregnancy and childhood, such as preterm birth, and intra- and extra-uterine growth restriction, have multiple, diverse contexts of complexity and interaction that determine the short- and long-term growth, health and development of all human beings. Early in life, genetically-guided somatic and cerebral development occurs alongside a psychism “in statu nascendi,” with the neural structures subjected to the effects of the intra- and extra-uterine environments in preparation for optimal postnatal functioning. Different trajectories of fetal cranial and abdominal growth have been identified before 25 weeks’ gestation, tracking differential growth and neurodevelopment at 2 years of age. Similarly, critical time-windows exist in the first 5–8 months of postnatal life because of interactions between the newborn and their environment, mother/care-givers and feeding practices. Understanding these complex relational processes requires abandoning classical, linear and mechanistic interpretations that are placed in rigid, artificial biological silos. Instead, we need to conduct longitudinal, interdisciplinary research and integrate the resulting new knowledge into clinical practice. An ecological-systemic approach is required to understand early human growth and development, based on a dynamic multidimensional process from the molecular or genomic level to the socio-economic-environmental context. For this, we need theoretical and methodological tools that permit a global understanding of CPS, delineating temporal trajectories and their conditioning factors, updated by the incorporation of new scientific discoveries. The potential to optimize human growth and development across chronological age and geographical locations – by implementing interventions or “treatments” during periods of greatest instability or vulnerability – should be recognized. Hence, it is imperative to take a holistic view of reproductive and perinatal issues, acknowledging at all levels the complexity and interactions of CPS and their sensitive periods, laying the foundations for further improvements in growth and development of populations, to maximize global human potential. We discuss here conceptual issues that should be considered for the development and implementation of such a strategy aimed at addressing the perinatal health problems of the new millenium.https://www.frontiersin.org/articles/10.3389/fnins.2022.856886/fullcomplex perinatal syndromeshuman growth and developmentpreterm birthextra-uterine growth restrictionintra-uterine growth restrictionpregnancy and childhood |
| spellingShingle | Roberto Frenquelli Marc Ratcliff Jimena Villar de Onis Jimena Villar de Onis Michelle Fernandes Michelle Fernandes Michelle Fernandes Fernando C. Barros Jane E. Hirst Aris T. Papageorghiou Aris T. Papageorghiou Stephen H. Kennedy Stephen H. Kennedy Jose Villar Jose Villar Complex Perinatal Syndromes Affecting Early Human Growth and Development: Issues to Consider to Understand Their Aetiology and Postnatal Effects Frontiers in Neuroscience complex perinatal syndromes human growth and development preterm birth extra-uterine growth restriction intra-uterine growth restriction pregnancy and childhood |
| title | Complex Perinatal Syndromes Affecting Early Human Growth and Development: Issues to Consider to Understand Their Aetiology and Postnatal Effects |
| title_full | Complex Perinatal Syndromes Affecting Early Human Growth and Development: Issues to Consider to Understand Their Aetiology and Postnatal Effects |
| title_fullStr | Complex Perinatal Syndromes Affecting Early Human Growth and Development: Issues to Consider to Understand Their Aetiology and Postnatal Effects |
| title_full_unstemmed | Complex Perinatal Syndromes Affecting Early Human Growth and Development: Issues to Consider to Understand Their Aetiology and Postnatal Effects |
| title_short | Complex Perinatal Syndromes Affecting Early Human Growth and Development: Issues to Consider to Understand Their Aetiology and Postnatal Effects |
| title_sort | complex perinatal syndromes affecting early human growth and development issues to consider to understand their aetiology and postnatal effects |
| topic | complex perinatal syndromes human growth and development preterm birth extra-uterine growth restriction intra-uterine growth restriction pregnancy and childhood |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.856886/full |
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