The Dietary Fiber Inulin Slows Progression of Chronic Kidney Disease–Mineral Bone Disorder (CKD‐MBD) in a Rat Model of CKD
Abstract Chronic kidney disease (CKD)–mineral bone disorder (CKD‐MBD) leads to fractures and cardiovascular disease. Observational studies suggest beneficial effects of dietary fiber on both bone and cardiovascular outcomes, but the effect of fiber on CKD‐MBD is unknown. To determine the effect of f...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | JBMR Plus |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jbm4.10837 |
| _version_ | 1797384929296777216 |
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| author | Annabel Biruete Neal X. Chen Corinne E. Metzger Shruthi Srinivasan Kalisha O'Neill Paul B. Fallen Austin Fonseca Hannah E. Wilson Henriette deLoor Pieter Evenepoel Kelly S. Swanson Matthew R. Allen Sharon M. Moe |
| author_facet | Annabel Biruete Neal X. Chen Corinne E. Metzger Shruthi Srinivasan Kalisha O'Neill Paul B. Fallen Austin Fonseca Hannah E. Wilson Henriette deLoor Pieter Evenepoel Kelly S. Swanson Matthew R. Allen Sharon M. Moe |
| author_sort | Annabel Biruete |
| collection | DOAJ |
| description | Abstract Chronic kidney disease (CKD)–mineral bone disorder (CKD‐MBD) leads to fractures and cardiovascular disease. Observational studies suggest beneficial effects of dietary fiber on both bone and cardiovascular outcomes, but the effect of fiber on CKD‐MBD is unknown. To determine the effect of fiber on CKD‐MBD, we fed the Cy/+ rat with progressive CKD a casein‐based diet of 0.7% phosphate with 10% inulin (fermentable fiber) or cellulose (non‐fermentable fiber) from 22 weeks to either 30 or 32 weeks of age (~30% and ~15% of normal kidney function; CKD 4 and 5). We assessed CKD‐MBD end points of biochemistry, bone quantity and quality, cardiovascular health, and cecal microbiota and serum gut‐derived uremic toxins. Results were analyzed by two‐way analysis of variance (ANOVA) to evaluate the main effects of CKD stage and inulin, and their interaction. The results showed that in CKD animals, inulin did not alter kidney function but reduced the increase from stage 4 to 5 in serum levels of phosphate and parathyroid hormone, but not fibroblast growth factor‐23 (FGF23). Bone turnover and cortical bone parameters were similarly improved but mechanical properties were not altered. Inulin slowed progression of aorta and cardiac calcification, left ventricular mass index, and fibrosis. To understand the mechanism, we assessed intestinal microbiota and found changes in alpha and beta diversity and significant changes in several taxa with inulin, together with a reduction in circulating gut derived uremic toxins such as indoxyl sulfate and short‐chain fatty acids. In conclusion, the addition of the fermentable fiber inulin to the diet of CKD rats led to a slowed progression of CKD‐MBD without affecting kidney function, likely mediated by changes in the gut microbiota composition and lowered gut‐derived uremic toxins. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research. |
| first_indexed | 2024-03-08T21:46:47Z |
| format | Article |
| id | doaj.art-21450129c6b94e78a48768ce1ab0b5a8 |
| institution | Directory Open Access Journal |
| issn | 2473-4039 |
| language | English |
| last_indexed | 2024-03-08T21:46:47Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | JBMR Plus |
| spelling | doaj.art-21450129c6b94e78a48768ce1ab0b5a82023-12-20T07:51:27ZengWileyJBMR Plus2473-40392023-12-01712n/an/a10.1002/jbm4.10837The Dietary Fiber Inulin Slows Progression of Chronic Kidney Disease–Mineral Bone Disorder (CKD‐MBD) in a Rat Model of CKDAnnabel Biruete0Neal X. Chen1Corinne E. Metzger2Shruthi Srinivasan3Kalisha O'Neill4Paul B. Fallen5Austin Fonseca6Hannah E. Wilson7Henriette deLoor8Pieter Evenepoel9Kelly S. Swanson10Matthew R. Allen11Sharon M. Moe12Department of Nutrition Science Purdue University West Lafayette IN USADepartment of Medicine, Division of Nephrology Indiana University School of Medicine Indianapolis IN USADepartment of Anatomy, Cell Biology, and Physiology Indiana University School of Medicine Indianapolis IN USADepartment of Medicine, Division of Nephrology Indiana University School of Medicine Indianapolis IN USADepartment of Medicine, Division of Nephrology Indiana University School of Medicine Indianapolis IN USADepartment of Anatomy, Cell Biology, and Physiology Indiana University School of Medicine Indianapolis IN USADepartment of Medicine, Division of Nephrology Indiana University School of Medicine Indianapolis IN USADepartment of Medicine, Division of Nephrology Indiana University School of Medicine Indianapolis IN USAKU Leuven Department of Microbiology and Immunology Nephrology and Renal Transplantation Research Group, KU Leuven Leuven BelgiumKU Leuven Department of Microbiology and Immunology Nephrology and Renal Transplantation Research Group, KU Leuven Leuven BelgiumDepartment of Animal Sciences University of Illinois at Urbana‐Champaign Urbana IL USADepartment of Medicine, Division of Nephrology Indiana University School of Medicine Indianapolis IN USADepartment of Medicine, Division of Nephrology Indiana University School of Medicine Indianapolis IN USAAbstract Chronic kidney disease (CKD)–mineral bone disorder (CKD‐MBD) leads to fractures and cardiovascular disease. Observational studies suggest beneficial effects of dietary fiber on both bone and cardiovascular outcomes, but the effect of fiber on CKD‐MBD is unknown. To determine the effect of fiber on CKD‐MBD, we fed the Cy/+ rat with progressive CKD a casein‐based diet of 0.7% phosphate with 10% inulin (fermentable fiber) or cellulose (non‐fermentable fiber) from 22 weeks to either 30 or 32 weeks of age (~30% and ~15% of normal kidney function; CKD 4 and 5). We assessed CKD‐MBD end points of biochemistry, bone quantity and quality, cardiovascular health, and cecal microbiota and serum gut‐derived uremic toxins. Results were analyzed by two‐way analysis of variance (ANOVA) to evaluate the main effects of CKD stage and inulin, and their interaction. The results showed that in CKD animals, inulin did not alter kidney function but reduced the increase from stage 4 to 5 in serum levels of phosphate and parathyroid hormone, but not fibroblast growth factor‐23 (FGF23). Bone turnover and cortical bone parameters were similarly improved but mechanical properties were not altered. Inulin slowed progression of aorta and cardiac calcification, left ventricular mass index, and fibrosis. To understand the mechanism, we assessed intestinal microbiota and found changes in alpha and beta diversity and significant changes in several taxa with inulin, together with a reduction in circulating gut derived uremic toxins such as indoxyl sulfate and short‐chain fatty acids. In conclusion, the addition of the fermentable fiber inulin to the diet of CKD rats led to a slowed progression of CKD‐MBD without affecting kidney function, likely mediated by changes in the gut microbiota composition and lowered gut‐derived uremic toxins. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.https://doi.org/10.1002/jbm4.10837BONECARDIOVASCULARCKD‐MINERAL BONE DISORDERDIETARY FIBERINULIN |
| spellingShingle | Annabel Biruete Neal X. Chen Corinne E. Metzger Shruthi Srinivasan Kalisha O'Neill Paul B. Fallen Austin Fonseca Hannah E. Wilson Henriette deLoor Pieter Evenepoel Kelly S. Swanson Matthew R. Allen Sharon M. Moe The Dietary Fiber Inulin Slows Progression of Chronic Kidney Disease–Mineral Bone Disorder (CKD‐MBD) in a Rat Model of CKD JBMR Plus BONE CARDIOVASCULAR CKD‐MINERAL BONE DISORDER DIETARY FIBER INULIN |
| title | The Dietary Fiber Inulin Slows Progression of Chronic Kidney Disease–Mineral Bone Disorder (CKD‐MBD) in a Rat Model of CKD |
| title_full | The Dietary Fiber Inulin Slows Progression of Chronic Kidney Disease–Mineral Bone Disorder (CKD‐MBD) in a Rat Model of CKD |
| title_fullStr | The Dietary Fiber Inulin Slows Progression of Chronic Kidney Disease–Mineral Bone Disorder (CKD‐MBD) in a Rat Model of CKD |
| title_full_unstemmed | The Dietary Fiber Inulin Slows Progression of Chronic Kidney Disease–Mineral Bone Disorder (CKD‐MBD) in a Rat Model of CKD |
| title_short | The Dietary Fiber Inulin Slows Progression of Chronic Kidney Disease–Mineral Bone Disorder (CKD‐MBD) in a Rat Model of CKD |
| title_sort | dietary fiber inulin slows progression of chronic kidney disease mineral bone disorder ckd mbd in a rat model of ckd |
| topic | BONE CARDIOVASCULAR CKD‐MINERAL BONE DISORDER DIETARY FIBER INULIN |
| url | https://doi.org/10.1002/jbm4.10837 |
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