Design, preparation, and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applications
Biocompatible, attuned, and congruent stimuli-responsive polymers of synthetic and plants and animals-based origins are essential raw materials for constructing bio-matching scaffolds, devices, and vehicles for payload deliveries, tissue engineering, therapeutics, and diagnostic purposes, and also a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-05-01
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| Series: | Nanotechnology Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/ntrev-2022-0106 |
| _version_ | 1811235738140803072 |
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| author | Ramburrun Poornima Khan Riaz A. Choonara Yahya E. |
| author_facet | Ramburrun Poornima Khan Riaz A. Choonara Yahya E. |
| author_sort | Ramburrun Poornima |
| collection | DOAJ |
| description | Biocompatible, attuned, and congruent stimuli-responsive polymers of synthetic and plants and animals-based origins are essential raw materials for constructing bio-matching scaffolds, devices, and vehicles for payload deliveries, tissue engineering, therapeutics, and diagnostic purposes, and also as fill-in materials at biosites for various biomimetic applications. The nanobiomaterials for nanobiotechnology, nanopharmaceuticals, and nanobioengineering requires to have fit-in intrinsic chemical, physical, physico-chemical, mechanical, biological, and chemo-biological characteristics. The developed nanomaterials are also required to be receptive and biomimicking in quality, and they must not be toxic at any stage of use or implantation, minimally or of zero order degradation together with aging and use-related degradation, and last a life-time. The biomaterial at the upgraded scale needs to possess intricate characteristics equivalent to the biological materials, and compatible to the biological-sites during transportation, delivery, and site-unloading, and use. Recent developments in nanobiomaterial substrate designs and structure, characteristics, design requirements, chemo-biological interface related bio-systems response-compatibility, biomaterial synchronized, contemporaneous, and evolving applications in health care, therapeutics, nanomedicine, bio-hazard prevention, toxicity and ways of toxicity-control are outlined. The structure-function relationship, scope and limitations, structural and functional classes, and diversified biological outreach are discussed. |
| first_indexed | 2024-04-12T11:56:41Z |
| format | Article |
| id | doaj.art-2145062468364f04aeaac5dbe8077455 |
| institution | Directory Open Access Journal |
| issn | 2191-9097 |
| language | English |
| last_indexed | 2024-04-12T11:56:41Z |
| publishDate | 2022-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanotechnology Reviews |
| spelling | doaj.art-2145062468364f04aeaac5dbe80774552022-12-22T03:33:58ZengDe GruyterNanotechnology Reviews2191-90972022-05-011111802182610.1515/ntrev-2022-0106Design, preparation, and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applicationsRamburrun Poornima0Khan Riaz A.1Choonara Yahya E.2Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaMedicinal Chemistry and Pharmacognosy Department, College of Pharmacy, Qassim University, Qassim 51452, Saudi ArabiaWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaBiocompatible, attuned, and congruent stimuli-responsive polymers of synthetic and plants and animals-based origins are essential raw materials for constructing bio-matching scaffolds, devices, and vehicles for payload deliveries, tissue engineering, therapeutics, and diagnostic purposes, and also as fill-in materials at biosites for various biomimetic applications. The nanobiomaterials for nanobiotechnology, nanopharmaceuticals, and nanobioengineering requires to have fit-in intrinsic chemical, physical, physico-chemical, mechanical, biological, and chemo-biological characteristics. The developed nanomaterials are also required to be receptive and biomimicking in quality, and they must not be toxic at any stage of use or implantation, minimally or of zero order degradation together with aging and use-related degradation, and last a life-time. The biomaterial at the upgraded scale needs to possess intricate characteristics equivalent to the biological materials, and compatible to the biological-sites during transportation, delivery, and site-unloading, and use. Recent developments in nanobiomaterial substrate designs and structure, characteristics, design requirements, chemo-biological interface related bio-systems response-compatibility, biomaterial synchronized, contemporaneous, and evolving applications in health care, therapeutics, nanomedicine, bio-hazard prevention, toxicity and ways of toxicity-control are outlined. The structure-function relationship, scope and limitations, structural and functional classes, and diversified biological outreach are discussed.https://doi.org/10.1515/ntrev-2022-0106nanobiomaterialsdesigns and preparationstructural knittingfunctional efficiencycontemporary and prospective uses |
| spellingShingle | Ramburrun Poornima Khan Riaz A. Choonara Yahya E. Design, preparation, and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applications Nanotechnology Reviews nanobiomaterials designs and preparation structural knitting functional efficiency contemporary and prospective uses |
| title | Design, preparation, and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applications |
| title_full | Design, preparation, and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applications |
| title_fullStr | Design, preparation, and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applications |
| title_full_unstemmed | Design, preparation, and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applications |
| title_short | Design, preparation, and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applications |
| title_sort | design preparation and functionalization of nanobiomaterials for enhanced efficacy in current and future biomedical applications |
| topic | nanobiomaterials designs and preparation structural knitting functional efficiency contemporary and prospective uses |
| url | https://doi.org/10.1515/ntrev-2022-0106 |
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