Crosstalk between tumor cells and lymphocytes modulates heparanase expression

Crosstalk between tumor cells and lymphocytes modulates heparanase expression

Abstract Background Heparanase (HPSE) is an endo-beta-glucuronidase that degrades heparan sulfate (HS) chains on proteoglycans. The oligosaccharides generated by HPSE promote angiogenesis, tumor growth and metastasis. Heparanase-2 (HPSE2), a close homolog of HPSE, does not exhibit catalytic activity...

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Bibliographic Details
Main Authors: Thérèse Rachell Theodoro, Leandro Luongo Matos, Renan Pelluzzi Cavalheiro, Giselle Zenker Justo, Helena Bonciani Nader, Maria Aparecida Silva Pinhal
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Translational Medicine
Subjects:
Tumor microenvironment
Breast neoplasms
HPSE
HPSE2
Heparan sulfate
Proteoglycans
Online Access:http://link.springer.com/article/10.1186/s12967-019-1853-z

Internet

http://link.springer.com/article/10.1186/s12967-019-1853-z

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