COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary Fibrosis
COVID-19 has an extensive impact on Homo sapiens globally. Patients with COVID-19 are at an increased risk of developing pulmonary fibrosis. A previous study identified that myofibroblasts could be derived from pulmonary endothelial lineage cells as an important cell source that contributes to pulmo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/14/11500 |
| _version_ | 1797589019684503552 |
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| author | Xiuju Wu Daoqin Zhang Kristina I. Boström Yucheng Yao |
| author_facet | Xiuju Wu Daoqin Zhang Kristina I. Boström Yucheng Yao |
| author_sort | Xiuju Wu |
| collection | DOAJ |
| description | COVID-19 has an extensive impact on Homo sapiens globally. Patients with COVID-19 are at an increased risk of developing pulmonary fibrosis. A previous study identified that myofibroblasts could be derived from pulmonary endothelial lineage cells as an important cell source that contributes to pulmonary fibrosis. Here, we analyzed publicly available data and showed that COVID-19 infection drove endothelial lineage cells towards myofibroblasts in pulmonary fibrosis of patients with COVID-19. We also discovered a similar differentiation trajectory in mouse lungs after viral infection. The results suggest that COVID-19 infection leads to the development of pulmonary fibrosis partly through the activation of endothelial cell (EC)-like myofibroblasts. |
| first_indexed | 2024-03-11T01:00:21Z |
| format | Article |
| id | doaj.art-214542ee35834b72b17d7647c536c8fe |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:00:21Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-214542ee35834b72b17d7647c536c8fe2023-11-18T19:40:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124141150010.3390/ijms241411500COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary FibrosisXiuju Wu0Daoqin Zhang1Kristina I. Boström2Yucheng Yao3Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Pediatrics, Stanford University, Stanford, CA 94305, USADivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USACOVID-19 has an extensive impact on Homo sapiens globally. Patients with COVID-19 are at an increased risk of developing pulmonary fibrosis. A previous study identified that myofibroblasts could be derived from pulmonary endothelial lineage cells as an important cell source that contributes to pulmonary fibrosis. Here, we analyzed publicly available data and showed that COVID-19 infection drove endothelial lineage cells towards myofibroblasts in pulmonary fibrosis of patients with COVID-19. We also discovered a similar differentiation trajectory in mouse lungs after viral infection. The results suggest that COVID-19 infection leads to the development of pulmonary fibrosis partly through the activation of endothelial cell (EC)-like myofibroblasts.https://www.mdpi.com/1422-0067/24/14/11500COVID-19endothelial cellspulmonary fibrosis |
| spellingShingle | Xiuju Wu Daoqin Zhang Kristina I. Boström Yucheng Yao COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary Fibrosis International Journal of Molecular Sciences COVID-19 endothelial cells pulmonary fibrosis |
| title | COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary Fibrosis |
| title_full | COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary Fibrosis |
| title_fullStr | COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary Fibrosis |
| title_full_unstemmed | COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary Fibrosis |
| title_short | COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary Fibrosis |
| title_sort | covid 19 infection may drive ec like myofibroblasts towards myofibroblasts to contribute to pulmonary fibrosis |
| topic | COVID-19 endothelial cells pulmonary fibrosis |
| url | https://www.mdpi.com/1422-0067/24/14/11500 |
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