Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinnings
Circadian rhythm impairment may play a role in Parkinson's disease (PD) pathophysiology. Recent literature associated circadian rhythm features to the risk of developing Parkinson and to its progression through stages. The association between the chronotype and the phenotype should be verified...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Neurobiology of Sleep and Circadian Rhythms |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451994423000068 |
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| author | Massimo Marano Jessica Rosati Alessandro Magliozzi Alessia Casamassa Alessia Rappa Gabriele Sergi Miriam Iannizzotto Ziv Yekutieli Angelo Luigi Vescovi Vincenzo Di Lazzaro |
| author_facet | Massimo Marano Jessica Rosati Alessandro Magliozzi Alessia Casamassa Alessia Rappa Gabriele Sergi Miriam Iannizzotto Ziv Yekutieli Angelo Luigi Vescovi Vincenzo Di Lazzaro |
| author_sort | Massimo Marano |
| collection | DOAJ |
| description | Circadian rhythm impairment may play a role in Parkinson's disease (PD) pathophysiology. Recent literature associated circadian rhythm features to the risk of developing Parkinson and to its progression through stages. The association between the chronotype and the phenotype should be verified on a clinical and biological point of view. Herein we investigate the chronotype of a sample of 50 PD patients with the Morningness Eveningness Questionnaire and monitor their daily activity with a motion sensor embedded in a smartphone. Fibroblasts were collected from PD patients (n = 5) and from sex/age matched controls (n = 3) and tested for the circadian expression of clock genes (CLOCK, BMAL1, PER1, CRY1), and for cell morphology, proliferation, and death. Our results show an association between the chronotype and the PD phenotype. The most representative clinical chronotypes were “moderate morning” (56%), the “intermediate” (24%) and, in a minor part, the “definite morning” (16%). They differed for axial motor impairment, presence of motor fluctuations and quality of life (p < 0.05). Patients with visuospatial dysfunction and patients with a higher PIGD score had a blunted motor daily activity (p = 0.006 and p = 0.001, respectively), independently by the influence of age and other motor scores. Fibroblasts obtained by PD patients (n = 5) had an impaired BMAL1 cycle compared to controls (n = 3, p = 0.01). Moreover, a PD flat BMAL1 profile was associated with the lowest cell proliferation and the largest cell morphology. This study contributes to the growing literature on CR abnormalities in the pathophysiology of Parkinson's disease providing a link between the clinical and biological patient chronotype and the disease phenomenology. |
| first_indexed | 2024-03-13T04:08:04Z |
| format | Article |
| id | doaj.art-214551a02ae3491bba2e54db265d004c |
| institution | Directory Open Access Journal |
| issn | 2451-9944 |
| language | English |
| last_indexed | 2024-03-13T04:08:04Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Sleep and Circadian Rhythms |
| spelling | doaj.art-214551a02ae3491bba2e54db265d004c2023-06-21T06:58:43ZengElsevierNeurobiology of Sleep and Circadian Rhythms2451-99442023-05-0114100094Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinningsMassimo Marano0Jessica Rosati1Alessandro Magliozzi2Alessia Casamassa3Alessia Rappa4Gabriele Sergi5Miriam Iannizzotto6Ziv Yekutieli7Angelo Luigi Vescovi8Vincenzo Di Lazzaro9Research Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 21, 00128, Roma, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro Del Portillo, 200, 00128, Roma, Italy; Corresponding author. Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Fondazione Policlinico Universitario Campus Bio-Medico, Viale Alvaro del Portillo 200, 00128, Roma, Italy.Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, ItalyResearch Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 21, 00128, Roma, ItalyFondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, ItalyFondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, ItalyResearch Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 21, 00128, Roma, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro Del Portillo, 200, 00128, Roma, ItalyResearch Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 21, 00128, Roma, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro Del Portillo, 200, 00128, Roma, ItalyMon4t Brain Monitor, Tel Aviv, IsraelFondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, ItalyResearch Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine, Università Campus Bio-Medico di Roma, Via Alvaro Del Portillo, 21, 00128, Roma, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro Del Portillo, 200, 00128, Roma, ItalyCircadian rhythm impairment may play a role in Parkinson's disease (PD) pathophysiology. Recent literature associated circadian rhythm features to the risk of developing Parkinson and to its progression through stages. The association between the chronotype and the phenotype should be verified on a clinical and biological point of view. Herein we investigate the chronotype of a sample of 50 PD patients with the Morningness Eveningness Questionnaire and monitor their daily activity with a motion sensor embedded in a smartphone. Fibroblasts were collected from PD patients (n = 5) and from sex/age matched controls (n = 3) and tested for the circadian expression of clock genes (CLOCK, BMAL1, PER1, CRY1), and for cell morphology, proliferation, and death. Our results show an association between the chronotype and the PD phenotype. The most representative clinical chronotypes were “moderate morning” (56%), the “intermediate” (24%) and, in a minor part, the “definite morning” (16%). They differed for axial motor impairment, presence of motor fluctuations and quality of life (p < 0.05). Patients with visuospatial dysfunction and patients with a higher PIGD score had a blunted motor daily activity (p = 0.006 and p = 0.001, respectively), independently by the influence of age and other motor scores. Fibroblasts obtained by PD patients (n = 5) had an impaired BMAL1 cycle compared to controls (n = 3, p = 0.01). Moreover, a PD flat BMAL1 profile was associated with the lowest cell proliferation and the largest cell morphology. This study contributes to the growing literature on CR abnormalities in the pathophysiology of Parkinson's disease providing a link between the clinical and biological patient chronotype and the disease phenomenology.http://www.sciencedirect.com/science/article/pii/S2451994423000068Circadian cycleSleepExcessive daytime sleepinessFibroblastsMotion sensor |
| spellingShingle | Massimo Marano Jessica Rosati Alessandro Magliozzi Alessia Casamassa Alessia Rappa Gabriele Sergi Miriam Iannizzotto Ziv Yekutieli Angelo Luigi Vescovi Vincenzo Di Lazzaro Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinnings Neurobiology of Sleep and Circadian Rhythms Circadian cycle Sleep Excessive daytime sleepiness Fibroblasts Motion sensor |
| title | Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinnings |
| title_full | Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinnings |
| title_fullStr | Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinnings |
| title_full_unstemmed | Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinnings |
| title_short | Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinnings |
| title_sort | circadian profile daytime activity and the parkinson s phenotype a motion sensor pilot study with neurobiological underpinnings |
| topic | Circadian cycle Sleep Excessive daytime sleepiness Fibroblasts Motion sensor |
| url | http://www.sciencedirect.com/science/article/pii/S2451994423000068 |
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