The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models
The different definitions of chronic pelvic/visceral pain used by international societies have changed over the years. These differences have a great impact on the way researchers study chronic pelvic/visceral pain. Recently, the role of systemic changes, including the role of the central nervous sy...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/696 |
| _version_ | 1797613320940814336 |
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| author | Ana Catarina Neto Mariana Santos-Pereira Pedro Abreu-Mendes Delminda Neves Henrique Almeida Francisco Cruz Ana Charrua |
| author_facet | Ana Catarina Neto Mariana Santos-Pereira Pedro Abreu-Mendes Delminda Neves Henrique Almeida Francisco Cruz Ana Charrua |
| author_sort | Ana Catarina Neto |
| collection | DOAJ |
| description | The different definitions of chronic pelvic/visceral pain used by international societies have changed over the years. These differences have a great impact on the way researchers study chronic pelvic/visceral pain. Recently, the role of systemic changes, including the role of the central nervous system, in the perpetuation and chronification of pelvic/visceral pain has gained weight. Consequently, researchers are using animal models that resemble those systemic changes rather than using models that are organ- or tissue-specific. In this review, we discuss the advantages and disadvantages of using bladder-centric and systemic models, enumerating some of the central nervous system changes and pain-related behaviors occurring in each model. We also present some drawbacks when using animal models and pain-related behavior tests and raise questions about possible, yet to be demonstrated, investigator-related bias. We also suggest new approaches to study chronic pelvic/visceral pain by refining existing animal models or using new ones. |
| first_indexed | 2024-03-11T06:54:13Z |
| format | Article |
| id | doaj.art-2145a322a5d145a19c9098febfbd409f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:54:13Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-2145a322a5d145a19c9098febfbd409f2023-11-17T09:44:14ZengMDPI AGBiomedicines2227-90592023-02-0111369610.3390/biomedicines11030696The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal ModelsAna Catarina Neto0Mariana Santos-Pereira1Pedro Abreu-Mendes2Delminda Neves3Henrique Almeida4Francisco Cruz5Ana Charrua6Experimental Biology Unit, Department of Biomedicine, Faculty of Medicine of University of Porto, 4200-319 Porto, PortugalExperimental Biology Unit, Department of Biomedicine, Faculty of Medicine of University of Porto, 4200-319 Porto, PortugalI3S—Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, PortugalExperimental Biology Unit, Department of Biomedicine, Faculty of Medicine of University of Porto, 4200-319 Porto, PortugalExperimental Biology Unit, Department of Biomedicine, Faculty of Medicine of University of Porto, 4200-319 Porto, PortugalI3S—Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, PortugalExperimental Biology Unit, Department of Biomedicine, Faculty of Medicine of University of Porto, 4200-319 Porto, PortugalThe different definitions of chronic pelvic/visceral pain used by international societies have changed over the years. These differences have a great impact on the way researchers study chronic pelvic/visceral pain. Recently, the role of systemic changes, including the role of the central nervous system, in the perpetuation and chronification of pelvic/visceral pain has gained weight. Consequently, researchers are using animal models that resemble those systemic changes rather than using models that are organ- or tissue-specific. In this review, we discuss the advantages and disadvantages of using bladder-centric and systemic models, enumerating some of the central nervous system changes and pain-related behaviors occurring in each model. We also present some drawbacks when using animal models and pain-related behavior tests and raise questions about possible, yet to be demonstrated, investigator-related bias. We also suggest new approaches to study chronic pelvic/visceral pain by refining existing animal models or using new ones.https://www.mdpi.com/2227-9059/11/3/696endometriosis pain syndromechronic primary bladder pain syndromeanimal model |
| spellingShingle | Ana Catarina Neto Mariana Santos-Pereira Pedro Abreu-Mendes Delminda Neves Henrique Almeida Francisco Cruz Ana Charrua The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models Biomedicines endometriosis pain syndrome chronic primary bladder pain syndrome animal model |
| title | The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models |
| title_full | The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models |
| title_fullStr | The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models |
| title_full_unstemmed | The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models |
| title_short | The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models |
| title_sort | unmet needs for studying chronic pelvic visceral pain using animal models |
| topic | endometriosis pain syndrome chronic primary bladder pain syndrome animal model |
| url | https://www.mdpi.com/2227-9059/11/3/696 |
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