Maturation of spinal motor neurons derived from human embryonic stem cells.

Maturation of spinal motor neurons derived from human embryonic stem cells.

Our understanding of motor neuron biology in humans is derived mainly from investigation of human postmortem tissue and more indirectly from live animal models such as rodents. Thus generation of motor neurons from human embryonic stem cells and human induced pluripotent stem cells is an important n...

Full description

Bibliographic Details
Main Authors:	Tomonori Takazawa, Gist F Croft, Mackenzie W Amoroso, Lorenz Studer, Hynek Wichterle, Amy B Macdermott
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3388990?pdf=render

Similar Items

Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification
by: G. Christopher Tan, et al.
Published: (2016-07-01)

Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro
by: Tulsi Patel, et al.
Published: (2022-09-01)

Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
by: Disi An, et al.
Published: (2019-06-01)

Transcriptome profiling of spinal muscular atrophy motor neurons derived from mouse embryonic stem cells.
by: Miho Maeda, et al.
Published: (2014-01-01)

Development and maturation of embryonic cortical neurons grafted into the damaged adult motor cortex
by: Nissrine Ballout, et al.
Published: (2016-08-01)

Stem cell therapy for spinal cord injury: The use of oligodendrocytes and motor neurons derived from human embryonic stem cells
by: Nimer Adeeb, et al.
Published: (2015-12-01)

Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells.
by: Tamaki Wada, et al.
Published: (2009-01-01)

Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures.
by: Nuno Jorge Lamas, et al.
Published: (2014-01-01)

Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes
by: Laurent Roybon, et al.
Published: (2013-09-01)

TRANSGENIC GDNF POSITIVELY INFLUENCES PROLIFERATION, DIFFERENTIATION, MATURATION AND SURVIVAL OF MOTOR NEURONS PRODUCED FROM MOUSE EMBRYONIC STEM CELLS.
by: Daniel Édgar Cortés, et al.
Published: (2016-09-01)

Mouse embryonic stem cell‐derived motor neurons are susceptible to ferroptosis
by: Alejandra M. Martinez, et al.
Published: (2023-03-01)

Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells
by: Josefina Inés del Mármol, et al.
Published: (2018-08-01)

Nicotinamide alone accelerates the conversion of mouse embryonic stem cells into mature neuronal populations.
by: Síle M Griffin, et al.
Published: (2017-01-01)

Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons.
by: Joy A Umbach, et al.
Published: (2012-01-01)

In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.
by: Bradley Watmuff, et al.
Published: (2012-01-01)

Embryonic Stem Cell-Derived Neurons as a Model System for Epigenome Maturation during Development
by: Sally Martin, et al.
Published: (2023-04-01)

Derivation of multipotent mesenchymal precursors from human embryonic stem cells.
by: Tiziano Barberi, et al.
Published: (2005-06-01)

Motor neurons and the generation of spinal motor neurons diversity
by: Nicolas eStifani
Published: (2014-10-01)

Embryonic stem cell-based mapping of developmental transcriptional programs
by: Mazzoni, Esteban O., et al.
Published: (2012)

Ectopic expression of neurogenin 2 alone is sufficient to induce differentiation of embryonic stem cells into mature neurons.
by: Eva C Thoma, et al.
Published: (2012-01-01)

LncRNA Litchi is a regulator for harmonizing maturity and resilient functionality in spinal motor neurons
by: Ho-Chiang Hsu, et al.
Published: (2024-03-01)

Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells
by: Mong, Jamie, et al.
Published: (2014)

Restoring Motor Neurons in Spinal Cord Injury With Induced Pluripotent Stem Cells
by: Matthew Trawczynski, et al.
Published: (2019-08-01)

Commentary: FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
by: Bert M. Verheijen, et al.
Published: (2017-12-01)

An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum
by: Gustavo A. Higuera, et al.
Published: (2017-08-01)

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity
by: Mazzoni, Esteban O., et al.
Published: (2014)

Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients
by: Christopher Grunseich, et al.
Published: (2014-10-01)

Fmrp regulates neuronal balance in embryonic motor circuit formation
by: Chase M. Barker, et al.
Published: (2022-11-01)

Directed neuronal differentiation of human embryonic stem cells
by: Noggle Scott A, et al.
Published: (2003-10-01)

Electrophysiological properties of embryonic stem cell-derived neurons.
by: Jessica R Risner-Janiczek, et al.
Published: (2011-01-01)

ZFX controls the self-renewal of human embryonic stem cells.
by: Sivan Harel, et al.
Published: (2012-01-01)

The Genetic and Epigenetic Journey of Embryonic Stem Cells into Mature Neural Cells
by: Brendan eOlynik, et al.
Published: (2012-05-01)

Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy.
by: Andrew J Schwab, et al.
Published: (2014-01-01)

Human mesenchymal amniotic fluid stem cells reveal an unexpected neuronal potential differentiating into functional spinal motor neurons
by: Giulia Gaggi, et al.
Published: (2022-07-01)

A gene expression fingerprint of <it>C. elegans </it>embryonic motor neurons
by: Dupuy Denis, et al.
Published: (2005-03-01)

Informativeness of neurophysiological diagnostic methods in the differentiation of motor neurons of spinal cord motor neuron disease
by: Albina Tretiakova, et al.
Published: (2013-12-01)

An optimized experimental strategy for efficient conversion of embryonic stem (ES)-derived mouse neural stem (NS) cells into a nearly homogeneous mature neuronal population
by: D. Spiliotopoulos, et al.
Published: (2009-05-01)

Toxicity effects of methamphetamine on embryonic stem cell-derived neuron
by: Rokhsareh Meamar, et al.
Published: (2012-01-01)

The differentiation of neuronal cells from mouse embryonic stem cells
by: UMUR N, et al.
Published: (2014-09-01)

Derivation of Functional Dopamine Neurons from Embryonic Stem Cells
by: Dae-Sung Kim, et al.
Published: (2007-02-01)