Cross-Sectional Association Between Body Fat Composition and Biomarkers of Inflammation and Endothelial Dysfunction in Children with Overweight/Obesity
Javed Yasin,1,* Charu Sharma,1,* Muhammad Jawad Hashim,2 Sania Al Hamed,3 Juma AlKaabi,1 Elhadi H Aburawi3 1Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 15551, United Arab Emirates; 2Departments of Family Medicine,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/cross-sectional-association-between-body-fat-composition-and-biomarker-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1828012159382061056 |
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| author | Yasin J Sharma C Hashim MJ Al Hamed S AlKaabi J Aburawi EH |
| author_facet | Yasin J Sharma C Hashim MJ Al Hamed S AlKaabi J Aburawi EH |
| author_sort | Yasin J |
| collection | DOAJ |
| description | Javed Yasin,1,* Charu Sharma,1,* Muhammad Jawad Hashim,2 Sania Al Hamed,3 Juma AlKaabi,1 Elhadi H Aburawi3 1Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 15551, United Arab Emirates; 2Departments of Family Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 15551, United Arab Emirates; 3Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 15551, United Arab Emirates*These authors contributed equally to this workCorrespondence: Elhadi H Aburawi; Juma AlKaabi, Email e.aburawi@uaeu.ac.ae; jalkaabi@uaeu.ac.aeBackground: Childhood obesity is most prevalent nutritional disorder worldwide. Studies on clinical correlations between body fat (BF) composition, lipid profile, inflammatory biomarkers, and endothelial dysfunction (ED) parameters in children from United Arab Emirates (UAE) are limited. Therefore, we aimed to study obesity pattern in children and determine clinical correlations with biomarkers.Methods: Children (6– 13 years) from different schools were divided into obese, overweight, and normal groups based upon Centers for Disease Control and Prevention weight-for-age centiles study (n=166). Anthropometric, BF composition, lipid profile, inflammatory, and ED biomarkers were determined and analyzed using SPSS software.Results: The mean age and weight ± SD of participants were 10.6 ± 2.6 years and 48.2 ± 19.5 kg with 65% as overweight or obese. In normal, overweight, and obese group male were 40 (70.2%), 35 (67.3%), and 40 (70.2%) and female were 17 (29.8%), 17 (32.7%) and 17 (29.8%). There was significant difference in age (p< 0.01), height (p< 0.01), weight (p< 0.01) among groups. Obesity markers (MCP-1, leptin, adiponectin) showed positive correlation with age, height, weight, WC, BF%, body fat mass (BFM), body muscle mass (BMM). A significant correlation (all p< 0.01) of BMM with SBP (r=0.412), DBP (r=0.255), MCP-1 (r=0.558), adiponectin (r=0.635), hs-CRP (r=0.263), IL-6 (r=0.348), TNF-alpha (r=0.370), ICAM-1 (r=0.237), and VCAM-1 (r=0.343). The inflammatory markers (ICAM-1, VCAM-1) showed significant correlations with age, height, weight, WC, BF%, BFM, BMM. Leptin significantly (all p< 0.01) correlated with age (r=0.470), height (r=0.423), weight (r=0.677), WC (r=0.606), BF (r=0.700), BFM (r=0.752), and BMM (r=0.524) and negatively correlated with TBW (r=− 0.701). Adiponectin also showed a significant (all p< 0.01) positive correlation with age, height, weight, WC, BF, BFM, and BMM.Conclusion: A strong association between BF composition, lipid profile, and inflammatory and ED biomarkers was observed in the study. Thus, immediate measures should be implemented to reduce risk of obesity and associated diseases.Keywords: body fat, inflammation, endothelial dysfunction, obesity, children |
| first_indexed | 2024-04-10T09:28:25Z |
| format | Article |
| id | doaj.art-21467993422a4fb38e9ee0a60c3e5143 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T09:28:25Z |
| publishDate | 2023-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-21467993422a4fb38e9ee0a60c3e51432023-02-19T13:56:56ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-02-01Volume 1648349381712Cross-Sectional Association Between Body Fat Composition and Biomarkers of Inflammation and Endothelial Dysfunction in Children with Overweight/ObesityYasin JSharma CHashim MJAl Hamed SAlKaabi JAburawi EHJaved Yasin,1,* Charu Sharma,1,* Muhammad Jawad Hashim,2 Sania Al Hamed,3 Juma AlKaabi,1 Elhadi H Aburawi3 1Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 15551, United Arab Emirates; 2Departments of Family Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 15551, United Arab Emirates; 3Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 15551, United Arab Emirates*These authors contributed equally to this workCorrespondence: Elhadi H Aburawi; Juma AlKaabi, Email e.aburawi@uaeu.ac.ae; jalkaabi@uaeu.ac.aeBackground: Childhood obesity is most prevalent nutritional disorder worldwide. Studies on clinical correlations between body fat (BF) composition, lipid profile, inflammatory biomarkers, and endothelial dysfunction (ED) parameters in children from United Arab Emirates (UAE) are limited. Therefore, we aimed to study obesity pattern in children and determine clinical correlations with biomarkers.Methods: Children (6– 13 years) from different schools were divided into obese, overweight, and normal groups based upon Centers for Disease Control and Prevention weight-for-age centiles study (n=166). Anthropometric, BF composition, lipid profile, inflammatory, and ED biomarkers were determined and analyzed using SPSS software.Results: The mean age and weight ± SD of participants were 10.6 ± 2.6 years and 48.2 ± 19.5 kg with 65% as overweight or obese. In normal, overweight, and obese group male were 40 (70.2%), 35 (67.3%), and 40 (70.2%) and female were 17 (29.8%), 17 (32.7%) and 17 (29.8%). There was significant difference in age (p< 0.01), height (p< 0.01), weight (p< 0.01) among groups. Obesity markers (MCP-1, leptin, adiponectin) showed positive correlation with age, height, weight, WC, BF%, body fat mass (BFM), body muscle mass (BMM). A significant correlation (all p< 0.01) of BMM with SBP (r=0.412), DBP (r=0.255), MCP-1 (r=0.558), adiponectin (r=0.635), hs-CRP (r=0.263), IL-6 (r=0.348), TNF-alpha (r=0.370), ICAM-1 (r=0.237), and VCAM-1 (r=0.343). The inflammatory markers (ICAM-1, VCAM-1) showed significant correlations with age, height, weight, WC, BF%, BFM, BMM. Leptin significantly (all p< 0.01) correlated with age (r=0.470), height (r=0.423), weight (r=0.677), WC (r=0.606), BF (r=0.700), BFM (r=0.752), and BMM (r=0.524) and negatively correlated with TBW (r=− 0.701). Adiponectin also showed a significant (all p< 0.01) positive correlation with age, height, weight, WC, BF, BFM, and BMM.Conclusion: A strong association between BF composition, lipid profile, and inflammatory and ED biomarkers was observed in the study. Thus, immediate measures should be implemented to reduce risk of obesity and associated diseases.Keywords: body fat, inflammation, endothelial dysfunction, obesity, childrenhttps://www.dovepress.com/cross-sectional-association-between-body-fat-composition-and-biomarker-peer-reviewed-fulltext-article-DMSObody fatinflammationendothelial dysfunctionobesitychildren |
| spellingShingle | Yasin J Sharma C Hashim MJ Al Hamed S AlKaabi J Aburawi EH Cross-Sectional Association Between Body Fat Composition and Biomarkers of Inflammation and Endothelial Dysfunction in Children with Overweight/Obesity Diabetes, Metabolic Syndrome and Obesity body fat inflammation endothelial dysfunction obesity children |
| title | Cross-Sectional Association Between Body Fat Composition and Biomarkers of Inflammation and Endothelial Dysfunction in Children with Overweight/Obesity |
| title_full | Cross-Sectional Association Between Body Fat Composition and Biomarkers of Inflammation and Endothelial Dysfunction in Children with Overweight/Obesity |
| title_fullStr | Cross-Sectional Association Between Body Fat Composition and Biomarkers of Inflammation and Endothelial Dysfunction in Children with Overweight/Obesity |
| title_full_unstemmed | Cross-Sectional Association Between Body Fat Composition and Biomarkers of Inflammation and Endothelial Dysfunction in Children with Overweight/Obesity |
| title_short | Cross-Sectional Association Between Body Fat Composition and Biomarkers of Inflammation and Endothelial Dysfunction in Children with Overweight/Obesity |
| title_sort | cross sectional association between body fat composition and biomarkers of inflammation and endothelial dysfunction in children with overweight obesity |
| topic | body fat inflammation endothelial dysfunction obesity children |
| url | https://www.dovepress.com/cross-sectional-association-between-body-fat-composition-and-biomarker-peer-reviewed-fulltext-article-DMSO |
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