Acid sphingomyelinase is induced by butyrate but does not initiate the anticancer effect of butyrate in HT29 and HepG2 cells

Acid sphingomyelinase is induced by butyrate but does not initiate the anticancer effect of butyrate in HT29 and HepG2 cells

Butyric acid and sphingomyelin (SM) affect colonic tumorigenesis. We examined the potential link between butyrate stimulation and SM metabolism in colonic and hepatic cancer cell lines. After incubating HT29 and HepG2 cells with butyrate and other short-chain fatty acids, we found that butyrate incr...

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Bibliographic Details
Main Authors: Jun Wu, Yajun Cheng, Bo A.G. Jönsson, Åke Nilsson, Rui-Dong Duan
Format: Article
Language:English
Published: Elsevier 2005-09-01
Series:Journal of Lipid Research
Subjects:
short-chain fatty acid
colon
liver
sphingomyelin
apoptosis
caspase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520329412

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