Effects of E-Cigarette Vapor Smoke on Pulmonary Alveoli in Rattus norvegicus Lungs
Introduction: Vapor is considered a safer alternative to tobacco cigarettes because the high nicotine content is less. However, vapor still contains substances that are classified as toxic to humans. Short-term exposure to vapors from liquids can induce an inflammatory response in the lungs and caus...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2023-09-01
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| Series: | Jurnal Respirasi |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/JR/article/view/46281 |
| _version_ | 1797656029651009536 |
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| author | Edward Pandu Wiriansya Dewi Rahman Muhammad Naufal Zuhair Syamsu Rijal Dzul Ikram Utomo Andi Pangnguriseng |
| author_facet | Edward Pandu Wiriansya Dewi Rahman Muhammad Naufal Zuhair Syamsu Rijal Dzul Ikram Utomo Andi Pangnguriseng |
| author_sort | Edward Pandu Wiriansya |
| collection | DOAJ |
| description | Introduction: Vapor is considered a safer alternative to tobacco cigarettes because the high nicotine content is less. However, vapor still contains substances that are classified as toxic to humans. Short-term exposure to vapors from liquids can induce an inflammatory response in the lungs and cause oxidative stress. This study aimed to determine the effects of e-cigarette vapor smoke on pulmonary alveoli in Rattus norvegicus lungs.
Methods: This was an experimental study on 32 adult male Rattus norvegicus rats. They were divided into two groups exposed to nicotine-containing vapor smoke two times a day for one and three months, respectively, and one group as control. After vapor exposure, the lung tissues of the rats were taken and then subjected to histopathological examination under a microscope.
Results: After exposure for one month, epithelial and endothelial cells degenerated, characterized by a decrease in collagen and elastin fibers in the extracellular matrix. For three months, there were changes, the alveolar membrane had no nucleus, the surrounding endothelial cells were not visible due to damage to the extracellular matrix, the alveolar lumen had widened, causing edema in the lumen of the alveoli, and the alveoli wall was destroyed. Therefore, the connection between the alveoli was stretched.
Conclusion: This study found that short-term exposure to nicotine vapor causes damage to the alveoli membrane. |
| first_indexed | 2024-03-11T17:24:29Z |
| format | Article |
| id | doaj.art-2149a76cac1447f5acd7f80081fba821 |
| institution | Directory Open Access Journal |
| issn | 2407-0831 2621-8372 |
| language | English |
| last_indexed | 2024-03-11T17:24:29Z |
| publishDate | 2023-09-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Jurnal Respirasi |
| spelling | doaj.art-2149a76cac1447f5acd7f80081fba8212023-10-19T06:59:53ZengUniversitas AirlanggaJurnal Respirasi2407-08312621-83722023-09-0193200205https://doi.org/10.20473/jr.v9-I.3.2023.200-205Effects of E-Cigarette Vapor Smoke on Pulmonary Alveoli in Rattus norvegicus LungsEdward Pandu Wiriansya0https://orcid.org/0000-0003-3853-8415Dewi Rahman1https://orcid.org/0009-0002-7191-4013Muhammad Naufal Zuhair2https://orcid.org/0000-0002-9953-3880Syamsu Rijal3https://orcid.org/0000-0002-2780-715XDzul Ikram4https://orcid.org/0000-0001-7751-4286Utomo Andi Pangnguriseng5https://orcid.org/0009-0000-4295-5583Department of Pulmonology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, Indonesia.Faculty of Medicine, Universitas Muslim Indonesia, Makassar, Indonesia.Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.Department of Pathology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, Indonesia.Department of Histology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, Indonesia.Faculty of Medicine, Shimane University, Shimane, Japan.Introduction: Vapor is considered a safer alternative to tobacco cigarettes because the high nicotine content is less. However, vapor still contains substances that are classified as toxic to humans. Short-term exposure to vapors from liquids can induce an inflammatory response in the lungs and cause oxidative stress. This study aimed to determine the effects of e-cigarette vapor smoke on pulmonary alveoli in Rattus norvegicus lungs. Methods: This was an experimental study on 32 adult male Rattus norvegicus rats. They were divided into two groups exposed to nicotine-containing vapor smoke two times a day for one and three months, respectively, and one group as control. After vapor exposure, the lung tissues of the rats were taken and then subjected to histopathological examination under a microscope. Results: After exposure for one month, epithelial and endothelial cells degenerated, characterized by a decrease in collagen and elastin fibers in the extracellular matrix. For three months, there were changes, the alveolar membrane had no nucleus, the surrounding endothelial cells were not visible due to damage to the extracellular matrix, the alveolar lumen had widened, causing edema in the lumen of the alveoli, and the alveoli wall was destroyed. Therefore, the connection between the alveoli was stretched. Conclusion: This study found that short-term exposure to nicotine vapor causes damage to the alveoli membrane.https://e-journal.unair.ac.id/JR/article/view/46281e-cigarette vaporinhalation exposurenicotinerattus norvegicustobacco use |
| spellingShingle | Edward Pandu Wiriansya Dewi Rahman Muhammad Naufal Zuhair Syamsu Rijal Dzul Ikram Utomo Andi Pangnguriseng Effects of E-Cigarette Vapor Smoke on Pulmonary Alveoli in Rattus norvegicus Lungs Jurnal Respirasi e-cigarette vapor inhalation exposure nicotine rattus norvegicus tobacco use |
| title | Effects of E-Cigarette Vapor Smoke on Pulmonary Alveoli in Rattus norvegicus Lungs |
| title_full | Effects of E-Cigarette Vapor Smoke on Pulmonary Alveoli in Rattus norvegicus Lungs |
| title_fullStr | Effects of E-Cigarette Vapor Smoke on Pulmonary Alveoli in Rattus norvegicus Lungs |
| title_full_unstemmed | Effects of E-Cigarette Vapor Smoke on Pulmonary Alveoli in Rattus norvegicus Lungs |
| title_short | Effects of E-Cigarette Vapor Smoke on Pulmonary Alveoli in Rattus norvegicus Lungs |
| title_sort | effects of e cigarette vapor smoke on pulmonary alveoli in rattus norvegicus lungs |
| topic | e-cigarette vapor inhalation exposure nicotine rattus norvegicus tobacco use |
| url | https://e-journal.unair.ac.id/JR/article/view/46281 |
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