Comparative Effectiveness of Conservative Management Compared to Cryotherapy in Localized Prostate Cancer Patients
The high frequency of treatment-related side effects for men with localized prostate cancer creates uncertainty for treatment outcomes. This study assessed the comparative effectiveness of treatment-related side effects associated with conservative management and cryotherapy in patients with localiz...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-09-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/1557988318781731 |
| _version_ | 1819088568990040064 |
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| author | Surbhi Shah PhD Henry N. Young PhD Ewan K. Cobran PhD |
| author_facet | Surbhi Shah PhD Henry N. Young PhD Ewan K. Cobran PhD |
| author_sort | Surbhi Shah PhD |
| collection | DOAJ |
| description | The high frequency of treatment-related side effects for men with localized prostate cancer creates uncertainty for treatment outcomes. This study assessed the comparative effectiveness of treatment-related side effects associated with conservative management and cryotherapy in patients with localized prostate cancer. A retrospective longitudinal cohort study was conducted, using the linked data of the Surveillance, Epidemiology, and End Results and Medicare, which included patients diagnosed from 2000 through year 2013, and their Medicare claims information from 2000 through 2014. To compare the differences in baseline characteristics and treatment-related side effects between the study cohorts, χ 2 tests were conducted. Multivariate logistic regression was used to assess the association between treatment selection and side effects. There were 7,998 and 3,051 patients in the conservative management and cryotherapy cohort, respectively. The likelihood of erectile dysfunction, lower urinary tract obstruction, urinary fistula, urinary incontinence, and hydronephrosis was reported to be significantly lower (53%, 35%, 69%, 65%, and 36%, respectively) in the conservative management cohort. Conservative management had a lower likelihood of treatment-related side effects compared to cryotherapy. However, further research is needed to compare other significant long-term outcomes such as costs associated with these treatment choices and quality of life. |
| first_indexed | 2024-12-21T21:54:07Z |
| format | Article |
| id | doaj.art-214a088e761e436f8c03a3099e029ae3 |
| institution | Directory Open Access Journal |
| issn | 1557-9883 1557-9891 |
| language | English |
| last_indexed | 2024-12-21T21:54:07Z |
| publishDate | 2018-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-214a088e761e436f8c03a3099e029ae32022-12-21T18:49:00ZengSAGE PublishingAmerican Journal of Men's Health1557-98831557-98912018-09-011210.1177/1557988318781731Comparative Effectiveness of Conservative Management Compared to Cryotherapy in Localized Prostate Cancer PatientsSurbhi Shah PhD0Henry N. Young PhD1Ewan K. Cobran PhD2Department of Clinical and Administrative Pharmacy, Division of Pharmaceutical Health Services, Outcomes, and Policy, College of Pharmacy, University of Georgia, Athens, GA, USADepartment of Clinical and Administrative Pharmacy, Division of Pharmaceutical Health Services, Outcomes, and Policy, College of Pharmacy, University of Georgia, Athens, GA, USADepartment of Clinical and Administrative Pharmacy, Division of Pharmaceutical Health Services, Outcomes, and Policy, College of Pharmacy, University of Georgia, Athens, GA, USAThe high frequency of treatment-related side effects for men with localized prostate cancer creates uncertainty for treatment outcomes. This study assessed the comparative effectiveness of treatment-related side effects associated with conservative management and cryotherapy in patients with localized prostate cancer. A retrospective longitudinal cohort study was conducted, using the linked data of the Surveillance, Epidemiology, and End Results and Medicare, which included patients diagnosed from 2000 through year 2013, and their Medicare claims information from 2000 through 2014. To compare the differences in baseline characteristics and treatment-related side effects between the study cohorts, χ 2 tests were conducted. Multivariate logistic regression was used to assess the association between treatment selection and side effects. There were 7,998 and 3,051 patients in the conservative management and cryotherapy cohort, respectively. The likelihood of erectile dysfunction, lower urinary tract obstruction, urinary fistula, urinary incontinence, and hydronephrosis was reported to be significantly lower (53%, 35%, 69%, 65%, and 36%, respectively) in the conservative management cohort. Conservative management had a lower likelihood of treatment-related side effects compared to cryotherapy. However, further research is needed to compare other significant long-term outcomes such as costs associated with these treatment choices and quality of life.https://doi.org/10.1177/1557988318781731 |
| spellingShingle | Surbhi Shah PhD Henry N. Young PhD Ewan K. Cobran PhD Comparative Effectiveness of Conservative Management Compared to Cryotherapy in Localized Prostate Cancer Patients American Journal of Men's Health |
| title | Comparative Effectiveness of Conservative Management Compared to Cryotherapy in Localized Prostate Cancer Patients |
| title_full | Comparative Effectiveness of Conservative Management Compared to Cryotherapy in Localized Prostate Cancer Patients |
| title_fullStr | Comparative Effectiveness of Conservative Management Compared to Cryotherapy in Localized Prostate Cancer Patients |
| title_full_unstemmed | Comparative Effectiveness of Conservative Management Compared to Cryotherapy in Localized Prostate Cancer Patients |
| title_short | Comparative Effectiveness of Conservative Management Compared to Cryotherapy in Localized Prostate Cancer Patients |
| title_sort | comparative effectiveness of conservative management compared to cryotherapy in localized prostate cancer patients |
| url | https://doi.org/10.1177/1557988318781731 |
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