LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis
Long non-coding RNAs have been confirmed closely related to the metastasis and angiogenesis of breast cancer (BC). LINC01857 can promote the growth and metastasis of BC cells. The present work focused on exploring the role of LINC01857 in BC metastasis and angiogenesis and investigating the possible...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-08-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2022-0525 |
| _version_ | 1811202924499435520 |
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| author | Qian Weiwei Yang Linlin Ni Yi Yin Fei Qin Lili Yang Yang |
| author_facet | Qian Weiwei Yang Linlin Ni Yi Yin Fei Qin Lili Yang Yang |
| author_sort | Qian Weiwei |
| collection | DOAJ |
| description | Long non-coding RNAs have been confirmed closely related to the metastasis and angiogenesis of breast cancer (BC). LINC01857 can promote the growth and metastasis of BC cells. The present work focused on exploring the role of LINC01857 in BC metastasis and angiogenesis and investigating the possible mechanisms. The results showed that LINC01857 and CENPQ were highly expressed in BC tissues and cells, while miR-2052 was contrarily expressed. In vitro study showed that low expression of linc01857 could inhibit the migration ability and vascularization of BC cells, and mir-2052 inhibitor partially restored the effect of si-LINC01857 on the migration ability and vascularization of BC cells. Likewise, inhibition of CENPQ can partially rescue the effects of miR-2052 inhibitor on the migration ability and vascularization of BC cells. In vivo studies showed that down-regulation of LINC01857 notably suppressed tumor growth and angiogenesis in nude mice. The miR-2052 inhibitor partially restored the effects of si-LINC01857. CENPQ suppression partially rescued the effects of the miR-2052 inhibitor. To conclude, LINC01857/miR-2052/CENPQ is the potential novel target for BC treatment. |
| first_indexed | 2024-04-12T02:47:10Z |
| format | Article |
| id | doaj.art-214d4015021a4a47b92f428223d01bf5 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T02:47:10Z |
| publishDate | 2022-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-214d4015021a4a47b92f428223d01bf52022-12-22T03:51:08ZengDe GruyterOpen Medicine2391-54632022-08-011711357136710.1515/med-2022-0525LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axisQian Weiwei0Yang Linlin1Ni Yi2Yin Fei3Qin Lili4Yang Yang5Department of Breast Surgery, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, ChinaDepartment of Oncology, Sheyang People’s Hospital, Yancheng City, Jiangsu Province 224300, ChinaDepartment of Breast Surgery, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, ChinaDepartment of Breast Surgery, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, ChinaDepartment of Endoscopic Center, Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province 226001, ChinaDepartment of Trauma Center, Affiliated Hospital of Nantong University, No. 20 Xisi Road, Chongchuan District, Nantong City, Jiangsu Province 226001, ChinaLong non-coding RNAs have been confirmed closely related to the metastasis and angiogenesis of breast cancer (BC). LINC01857 can promote the growth and metastasis of BC cells. The present work focused on exploring the role of LINC01857 in BC metastasis and angiogenesis and investigating the possible mechanisms. The results showed that LINC01857 and CENPQ were highly expressed in BC tissues and cells, while miR-2052 was contrarily expressed. In vitro study showed that low expression of linc01857 could inhibit the migration ability and vascularization of BC cells, and mir-2052 inhibitor partially restored the effect of si-LINC01857 on the migration ability and vascularization of BC cells. Likewise, inhibition of CENPQ can partially rescue the effects of miR-2052 inhibitor on the migration ability and vascularization of BC cells. In vivo studies showed that down-regulation of LINC01857 notably suppressed tumor growth and angiogenesis in nude mice. The miR-2052 inhibitor partially restored the effects of si-LINC01857. CENPQ suppression partially rescued the effects of the miR-2052 inhibitor. To conclude, LINC01857/miR-2052/CENPQ is the potential novel target for BC treatment.https://doi.org/10.1515/med-2022-0525breast cancerlncrna linc01857mir-2052cenpqangiogenesismetastasis |
| spellingShingle | Qian Weiwei Yang Linlin Ni Yi Yin Fei Qin Lili Yang Yang LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis Open Medicine breast cancer lncrna linc01857 mir-2052 cenpq angiogenesis metastasis |
| title | LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis |
| title_full | LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis |
| title_fullStr | LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis |
| title_full_unstemmed | LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis |
| title_short | LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis |
| title_sort | lncrna linc01857 reduces metastasis and angiogenesis in breast cancer cells via regulating mir 2052 cenpq axis |
| topic | breast cancer lncrna linc01857 mir-2052 cenpq angiogenesis metastasis |
| url | https://doi.org/10.1515/med-2022-0525 |
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