Antiproliferative evaluation of various aminoquinoline derivatives
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2019-12-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2019-0048 |
| _version_ | 1818729392923213824 |
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| author | Zorc Branka Rajić Zrinka Perković Ivana |
| author_facet | Zorc Branka Rajić Zrinka Perković Ivana |
| author_sort | Zorc Branka |
| collection | DOAJ |
| description | Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines. |
| first_indexed | 2024-12-17T22:45:10Z |
| format | Article |
| id | doaj.art-214d5742d5284647b96e11ce6bf126d2 |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2024-12-17T22:45:10Z |
| publishDate | 2019-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-214d5742d5284647b96e11ce6bf126d22022-12-21T21:29:49ZengSciendoActa Pharmaceutica1846-95582019-12-0169466167210.2478/acph-2019-0048acph-2019-0048Antiproliferative evaluation of various aminoquinoline derivativesZorc Branka0Rajić Zrinka1Perković Ivana2University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry10 000Zagreb, CroatiaUniversity of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry10 000Zagreb, CroatiaUniversity of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry10 000Zagreb, CroatiaFour classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.https://doi.org/10.2478/acph-2019-0048primaquinechloroquinemefloquinefumardiamideantiproliferative activity |
| spellingShingle | Zorc Branka Rajić Zrinka Perković Ivana Antiproliferative evaluation of various aminoquinoline derivatives Acta Pharmaceutica primaquine chloroquine mefloquine fumardiamide antiproliferative activity |
| title | Antiproliferative evaluation of various aminoquinoline derivatives |
| title_full | Antiproliferative evaluation of various aminoquinoline derivatives |
| title_fullStr | Antiproliferative evaluation of various aminoquinoline derivatives |
| title_full_unstemmed | Antiproliferative evaluation of various aminoquinoline derivatives |
| title_short | Antiproliferative evaluation of various aminoquinoline derivatives |
| title_sort | antiproliferative evaluation of various aminoquinoline derivatives |
| topic | primaquine chloroquine mefloquine fumardiamide antiproliferative activity |
| url | https://doi.org/10.2478/acph-2019-0048 |
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