MiSelect R System: the validation of a new detection system of CTCs and their correlation with prognosis in non-metastatic CRC patients
Abstract Circulating tumor cells (CTCs) in blood are accepted as a prognostic marker for patients with metastatic colorectal cancer (CRC). However, there is limited data on the use of CTCs as a prognostic marker for non-metastatic patients. In the current study, we used a rare cell automated analysi...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-31346-9 |
| _version_ | 1827979494191792128 |
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| author | Chun-Chi Lin Chih-Yung Yang Tzu-Chao Hung Chun-Hung Wang Sheng-Wen Wei Perry Schiro Ju-Yu Tseng Chi-Hung Lin Jeng-Kai Jiang |
| author_facet | Chun-Chi Lin Chih-Yung Yang Tzu-Chao Hung Chun-Hung Wang Sheng-Wen Wei Perry Schiro Ju-Yu Tseng Chi-Hung Lin Jeng-Kai Jiang |
| author_sort | Chun-Chi Lin |
| collection | DOAJ |
| description | Abstract Circulating tumor cells (CTCs) in blood are accepted as a prognostic marker for patients with metastatic colorectal cancer (CRC). However, there is limited data on the use of CTCs as a prognostic marker for non-metastatic patients. In the current study, we used a rare cell automated analysis platform, the MiSelect R System, to enumerate CTCs from blood in non-metastatic CRC patients, and corelated the number of CTCs with the clinical staging and survival. The presence of CTCs in mesenteric vein blood (MVB) samples from 101 CRC patients was significantly associated with T stage. Patients with 1 or more CTCs per 8 mL of MVB exhibited significantly worse disease-free survival (DFS) and cancer-specific survival (CSS) compared to patient without CTCs. The presence of CTCs before surgery is an independent marker for both DFS and CSS. CTC presence after surgical resection is also a prognostic marker. CTCs are a potentially useful prognostic and predictive biomarker in non-metastatic CRC patients that may further stratify patient’s risk status within different stages of disease. |
| first_indexed | 2024-04-09T21:37:37Z |
| format | Article |
| id | doaj.art-214eeb6d4ce14cc9bd9b103ac0a2514c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T21:37:37Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-214eeb6d4ce14cc9bd9b103ac0a2514c2023-03-26T11:09:47ZengNature PortfolioScientific Reports2045-23222023-03-0113111010.1038/s41598-023-31346-9MiSelect R System: the validation of a new detection system of CTCs and their correlation with prognosis in non-metastatic CRC patientsChun-Chi Lin0Chih-Yung Yang1Tzu-Chao Hung2Chun-Hung Wang3Sheng-Wen Wei4Perry Schiro5Ju-Yu Tseng6Chi-Hung Lin7Jeng-Kai Jiang8Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General HospitalDepartment of Teaching and Research, Taipei City HospitalMiCareo Taiwan Co., Ltd.MiCareo Taiwan Co., Ltd.MiCareo Taiwan Co., Ltd.MiCareo Taiwan Co., Ltd.MiCareo Taiwan Co., Ltd.Department of Biological Science and Technology, National Yang-Ming Chiao-Tung UniversityDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General HospitalAbstract Circulating tumor cells (CTCs) in blood are accepted as a prognostic marker for patients with metastatic colorectal cancer (CRC). However, there is limited data on the use of CTCs as a prognostic marker for non-metastatic patients. In the current study, we used a rare cell automated analysis platform, the MiSelect R System, to enumerate CTCs from blood in non-metastatic CRC patients, and corelated the number of CTCs with the clinical staging and survival. The presence of CTCs in mesenteric vein blood (MVB) samples from 101 CRC patients was significantly associated with T stage. Patients with 1 or more CTCs per 8 mL of MVB exhibited significantly worse disease-free survival (DFS) and cancer-specific survival (CSS) compared to patient without CTCs. The presence of CTCs before surgery is an independent marker for both DFS and CSS. CTC presence after surgical resection is also a prognostic marker. CTCs are a potentially useful prognostic and predictive biomarker in non-metastatic CRC patients that may further stratify patient’s risk status within different stages of disease.https://doi.org/10.1038/s41598-023-31346-9 |
| spellingShingle | Chun-Chi Lin Chih-Yung Yang Tzu-Chao Hung Chun-Hung Wang Sheng-Wen Wei Perry Schiro Ju-Yu Tseng Chi-Hung Lin Jeng-Kai Jiang MiSelect R System: the validation of a new detection system of CTCs and their correlation with prognosis in non-metastatic CRC patients Scientific Reports |
| title | MiSelect R System: the validation of a new detection system of CTCs and their correlation with prognosis in non-metastatic CRC patients |
| title_full | MiSelect R System: the validation of a new detection system of CTCs and their correlation with prognosis in non-metastatic CRC patients |
| title_fullStr | MiSelect R System: the validation of a new detection system of CTCs and their correlation with prognosis in non-metastatic CRC patients |
| title_full_unstemmed | MiSelect R System: the validation of a new detection system of CTCs and their correlation with prognosis in non-metastatic CRC patients |
| title_short | MiSelect R System: the validation of a new detection system of CTCs and their correlation with prognosis in non-metastatic CRC patients |
| title_sort | miselect r system the validation of a new detection system of ctcs and their correlation with prognosis in non metastatic crc patients |
| url | https://doi.org/10.1038/s41598-023-31346-9 |
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