Subretinal hyperreflective material morphology in neovascular age-related macular degeneration: A case control study
Purpose: The aim of this study was to evaluate the association of morphological features of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA) and scar formation in eyes with neovascular age-related macular degeneration (neovascular AMD) and to compare with c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=7;spage=1862;epage=1866;aulast=Alex |
| _version_ | 1819112232719482880 |
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| author | Divya Alex Anantharaman Giridhar Mahesh Gopalakrishnan Swati Indurkhya Shivam Madan |
| author_facet | Divya Alex Anantharaman Giridhar Mahesh Gopalakrishnan Swati Indurkhya Shivam Madan |
| author_sort | Divya Alex |
| collection | DOAJ |
| description | Purpose: The aim of this study was to evaluate the association of morphological features of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA) and scar formation in eyes with neovascular age-related macular degeneration (neovascular AMD) and to compare with controls of neovascular AMD without SHRM. Methods: Retrospective analysis of 157 wet AMD eyes with SHRM and 50 eyes without SHRM treated with Anti-VEGF. Baseline spectral domain-OCT characteristics (SHRM location, height, width, area, reflectivity, border definition) were collected and were correlated with VA at baseline, 3, 6, 12 months and looked for development of scar and geographical atrophy (GA) and were compared to the control group. Results: When compared to the control, baseline parameters with a significant predictive value of 12-VA were presence of SHRM, foveal involvement of SHRM, high reflective SHRM, well-defined SHRM borders and thick SHRM. VA was decreased with greater SHRM height, width and area (P < 0.001). Decreasing reflectivity of SHRM lesions and disappearance of SHRM correlated with better VA at 12 months (P < 0.05). At 12 months, scar and GA was present more often in eyes with persistent SHRM than in eyes with SHRM that resolved and those without SHRM in the control group. Conclusion: SHRM can be considered as a surrogate OCT biomarker in predicting final visual outcome in neovascular age-related macular degeneration. Baseline parameters predicting poorer vision at 12-follow-up were presence of SHRM involving the fovea, well-defined SHRM borders, greater SHRM height, width and area and persistence of SHRM with Anti-VEGF therapy. |
| first_indexed | 2024-12-22T04:10:14Z |
| format | Article |
| id | doaj.art-214f9d9fa6b9422e81d93102445b4aba |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-22T04:10:14Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-214f9d9fa6b9422e81d93102445b4aba2022-12-21T18:39:32ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892021-01-016971862186610.4103/ijo.IJO_3156_20Subretinal hyperreflective material morphology in neovascular age-related macular degeneration: A case control studyDivya AlexAnantharaman GiridharMahesh GopalakrishnanSwati IndurkhyaShivam MadanPurpose: The aim of this study was to evaluate the association of morphological features of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA) and scar formation in eyes with neovascular age-related macular degeneration (neovascular AMD) and to compare with controls of neovascular AMD without SHRM. Methods: Retrospective analysis of 157 wet AMD eyes with SHRM and 50 eyes without SHRM treated with Anti-VEGF. Baseline spectral domain-OCT characteristics (SHRM location, height, width, area, reflectivity, border definition) were collected and were correlated with VA at baseline, 3, 6, 12 months and looked for development of scar and geographical atrophy (GA) and were compared to the control group. Results: When compared to the control, baseline parameters with a significant predictive value of 12-VA were presence of SHRM, foveal involvement of SHRM, high reflective SHRM, well-defined SHRM borders and thick SHRM. VA was decreased with greater SHRM height, width and area (P < 0.001). Decreasing reflectivity of SHRM lesions and disappearance of SHRM correlated with better VA at 12 months (P < 0.05). At 12 months, scar and GA was present more often in eyes with persistent SHRM than in eyes with SHRM that resolved and those without SHRM in the control group. Conclusion: SHRM can be considered as a surrogate OCT biomarker in predicting final visual outcome in neovascular age-related macular degeneration. Baseline parameters predicting poorer vision at 12-follow-up were presence of SHRM involving the fovea, well-defined SHRM borders, greater SHRM height, width and area and persistence of SHRM with Anti-VEGF therapy.http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=7;spage=1862;epage=1866;aulast=Alexanti-vegf therapygeographic atrophyneovascular age-related macular degenerationscar formationsubretinal hyper reflective materialvisual acuity |
| spellingShingle | Divya Alex Anantharaman Giridhar Mahesh Gopalakrishnan Swati Indurkhya Shivam Madan Subretinal hyperreflective material morphology in neovascular age-related macular degeneration: A case control study Indian Journal of Ophthalmology anti-vegf therapy geographic atrophy neovascular age-related macular degeneration scar formation subretinal hyper reflective material visual acuity |
| title | Subretinal hyperreflective material morphology in neovascular age-related macular degeneration: A case control study |
| title_full | Subretinal hyperreflective material morphology in neovascular age-related macular degeneration: A case control study |
| title_fullStr | Subretinal hyperreflective material morphology in neovascular age-related macular degeneration: A case control study |
| title_full_unstemmed | Subretinal hyperreflective material morphology in neovascular age-related macular degeneration: A case control study |
| title_short | Subretinal hyperreflective material morphology in neovascular age-related macular degeneration: A case control study |
| title_sort | subretinal hyperreflective material morphology in neovascular age related macular degeneration a case control study |
| topic | anti-vegf therapy geographic atrophy neovascular age-related macular degeneration scar formation subretinal hyper reflective material visual acuity |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=7;spage=1862;epage=1866;aulast=Alex |
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