A Pilot Study About the Dysfunction of Adipose Tissue in Male, Sleep Apneic Patients in Relation to Psychological Symptoms
Introduction: Obstructive sleep apnea (OSA) and its cardiometabolic alterations are closely associated with visceral obesity. Patients with OSA frequently present with symptoms of depression and anxiety. Although these subjective symptoms of OSA are the result of complex biological dysregulation, it...
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| Format: | Article |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00527/full |
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| author | Georgia Trakada Pantelis T. Nikolaidis Nicholas-Tiberio Economou Dimitrios Sakkas Giorgos Giagkou Stratigoula Sakellariou Konstantina Kyriakopoulou Efstratios Patsouris Luigi Ferini-Strambi Lemonia Velentza Anastasios Kallianos Thomas Rosemann Beat Knechtle Asimina Mitrakou |
| author_facet | Georgia Trakada Pantelis T. Nikolaidis Nicholas-Tiberio Economou Dimitrios Sakkas Giorgos Giagkou Stratigoula Sakellariou Konstantina Kyriakopoulou Efstratios Patsouris Luigi Ferini-Strambi Lemonia Velentza Anastasios Kallianos Thomas Rosemann Beat Knechtle Asimina Mitrakou |
| author_sort | Georgia Trakada |
| collection | DOAJ |
| description | Introduction: Obstructive sleep apnea (OSA) and its cardiometabolic alterations are closely associated with visceral obesity. Patients with OSA frequently present with symptoms of depression and anxiety. Although these subjective symptoms of OSA are the result of complex biological dysregulation, it remains unclear if they have a direct effect on the dysfunction of adipose tissue.Methods: In a pilot, prospective, randomized study, we evaluated 10 recently diagnosed male patients with severe OSA by full polysomnography (PSG) and 4 male non-apneic subjects matched for age and body mass index (BMI) with abdomen adipose tissue biopsies. Subjects with diabetes/prediabetes and cardiovascular and psychiatric diseases and who are current smokers were excluded. All patients underwent anthropometric measurements and completed the following questionnaires: Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS), and Hospital Anxiety and Depression Scale (HADS-A and HADS-D). Fasting venous blood samples were collected on the day after PSG, between 8:00 and 9:00 a.m., after an overnight fast. Fat biopsies were performed at the same time periods and adipose tissue samples of 300 mg were obtained from abdominal fat. Fat cell size, extent of fibrosis, vascularity, leukocyte common antigen inflammatory infiltration, and tissue macrophage accumulation were microscopically evaluated.Results: The mean age of the group was 47.4 ± 13.8 years, with mean BMI of 35.8 ± 4.8 kg/m2 and mean apnea-hypopnea index of 79.4 ± 46.1 events per hour of sleep (severe OSA). HADS-A and HADS-D scores were 5.8 ± 2.3 (3.0–8.0) and 4.7 ± 2.3 (2.0–8.0), respectively. HADS-A score correlated positively with macrophage accumulation in fat biopsy (r = 0.82, p = 0.047), whereas ESS, FSS, and HADS-D did not. Severity of fibrosis correlated largely with waist circumference (r = -0.66, p = 0.038) and neck circumference (r = -0.790, p = 0.006). Respiratory events correlated negatively with the extent of vascularization of adipose tissue (r = -0.614, p = 0.05).Conclusions: In the preliminary results of our pilot study, we assessed that the symptoms of anxiety mainly contribute to macrophage accumulation, whereas the increased number of respiratory events reduces the extent of vascularization in visceral fat in OSA. Based on this observation, further larger studies are required to verify if anxious OSA patients are more vulnerable to the metabolic manifestations of the syndrome. |
| first_indexed | 2024-12-20T14:28:19Z |
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| language | English |
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| publishDate | 2019-07-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-214fdb498d6a4a0eb84e8230e2fa5f1c2022-12-21T19:37:42ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-07-011010.3389/fpsyt.2019.00527453601A Pilot Study About the Dysfunction of Adipose Tissue in Male, Sleep Apneic Patients in Relation to Psychological SymptomsGeorgia Trakada0Pantelis T. Nikolaidis1Nicholas-Tiberio Economou2Dimitrios Sakkas3Giorgos Giagkou4Stratigoula Sakellariou5Konstantina Kyriakopoulou6Efstratios Patsouris7Luigi Ferini-Strambi8Lemonia Velentza9Anastasios Kallianos10Thomas Rosemann11Beat Knechtle12Asimina Mitrakou13Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, GreeceExercise Physiology Laboratory, Nikaia, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece1st Department of Pathology, National and Kapodistrian University of Athens School of Medicine, Athens, GreeceRadiology (Ultrasound) Department, Athens Medical Center, Athens, Greece1st Department of Pathology, National and Kapodistrian University of Athens School of Medicine, Athens, GreeceDepartment of Clinical Neurosciences, Neurology - Sleep Disorders Center, IRCCS San Raffaele Scientific Institute, Milan, ItalyDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, GreeceInstitute of Primary Care, University of Zurich, Zurich, SwitzerlandInstitute of Primary Care, University of Zurich, Zurich, SwitzerlandDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, GreeceIntroduction: Obstructive sleep apnea (OSA) and its cardiometabolic alterations are closely associated with visceral obesity. Patients with OSA frequently present with symptoms of depression and anxiety. Although these subjective symptoms of OSA are the result of complex biological dysregulation, it remains unclear if they have a direct effect on the dysfunction of adipose tissue.Methods: In a pilot, prospective, randomized study, we evaluated 10 recently diagnosed male patients with severe OSA by full polysomnography (PSG) and 4 male non-apneic subjects matched for age and body mass index (BMI) with abdomen adipose tissue biopsies. Subjects with diabetes/prediabetes and cardiovascular and psychiatric diseases and who are current smokers were excluded. All patients underwent anthropometric measurements and completed the following questionnaires: Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS), and Hospital Anxiety and Depression Scale (HADS-A and HADS-D). Fasting venous blood samples were collected on the day after PSG, between 8:00 and 9:00 a.m., after an overnight fast. Fat biopsies were performed at the same time periods and adipose tissue samples of 300 mg were obtained from abdominal fat. Fat cell size, extent of fibrosis, vascularity, leukocyte common antigen inflammatory infiltration, and tissue macrophage accumulation were microscopically evaluated.Results: The mean age of the group was 47.4 ± 13.8 years, with mean BMI of 35.8 ± 4.8 kg/m2 and mean apnea-hypopnea index of 79.4 ± 46.1 events per hour of sleep (severe OSA). HADS-A and HADS-D scores were 5.8 ± 2.3 (3.0–8.0) and 4.7 ± 2.3 (2.0–8.0), respectively. HADS-A score correlated positively with macrophage accumulation in fat biopsy (r = 0.82, p = 0.047), whereas ESS, FSS, and HADS-D did not. Severity of fibrosis correlated largely with waist circumference (r = -0.66, p = 0.038) and neck circumference (r = -0.790, p = 0.006). Respiratory events correlated negatively with the extent of vascularization of adipose tissue (r = -0.614, p = 0.05).Conclusions: In the preliminary results of our pilot study, we assessed that the symptoms of anxiety mainly contribute to macrophage accumulation, whereas the increased number of respiratory events reduces the extent of vascularization in visceral fat in OSA. Based on this observation, further larger studies are required to verify if anxious OSA patients are more vulnerable to the metabolic manifestations of the syndrome.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00527/fullobstructive sleep apneaHospital Anxiety and Depression Scaleadipose tissueabdominal fatbiopsy |
| spellingShingle | Georgia Trakada Pantelis T. Nikolaidis Nicholas-Tiberio Economou Dimitrios Sakkas Giorgos Giagkou Stratigoula Sakellariou Konstantina Kyriakopoulou Efstratios Patsouris Luigi Ferini-Strambi Lemonia Velentza Anastasios Kallianos Thomas Rosemann Beat Knechtle Asimina Mitrakou A Pilot Study About the Dysfunction of Adipose Tissue in Male, Sleep Apneic Patients in Relation to Psychological Symptoms Frontiers in Psychiatry obstructive sleep apnea Hospital Anxiety and Depression Scale adipose tissue abdominal fat biopsy |
| title | A Pilot Study About the Dysfunction of Adipose Tissue in Male, Sleep Apneic Patients in Relation to Psychological Symptoms |
| title_full | A Pilot Study About the Dysfunction of Adipose Tissue in Male, Sleep Apneic Patients in Relation to Psychological Symptoms |
| title_fullStr | A Pilot Study About the Dysfunction of Adipose Tissue in Male, Sleep Apneic Patients in Relation to Psychological Symptoms |
| title_full_unstemmed | A Pilot Study About the Dysfunction of Adipose Tissue in Male, Sleep Apneic Patients in Relation to Psychological Symptoms |
| title_short | A Pilot Study About the Dysfunction of Adipose Tissue in Male, Sleep Apneic Patients in Relation to Psychological Symptoms |
| title_sort | pilot study about the dysfunction of adipose tissue in male sleep apneic patients in relation to psychological symptoms |
| topic | obstructive sleep apnea Hospital Anxiety and Depression Scale adipose tissue abdominal fat biopsy |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00527/full |
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