Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses
The virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses. One of the host antiviral defenses is the nonsense-mediated mRNA decay (NMD), an evolutionarily c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/4/816 |
| _version_ | 1797603189362524160 |
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| author | Md Robel Ahmed Zhiyou Du |
| author_facet | Md Robel Ahmed Zhiyou Du |
| author_sort | Md Robel Ahmed |
| collection | DOAJ |
| description | The virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses. One of the host antiviral defenses is the nonsense-mediated mRNA decay (NMD), an evolutionarily conserved mechanism for RNA quality control in eukaryotic cells. NMD ensures the accuracy of mRNA translation by removing the abnormal mRNAs harboring pre-matured stop codons. Many RNA viruses have a genome that contains internal stop codon(s) (iTC). Akin to the premature termination codon in aberrant RNA transcripts, the presence of iTC would activate NMD to degrade iTC-containing viral genomes. A couple of viruses have been reported to be sensitive to the NMD-mediated antiviral defense, while some viruses have evolved with specific <i>cis</i>-acting RNA features or <i>trans</i>-acting viral proteins to overcome or escape from NMD. Recently, increasing light has been shed on the NMD–virus interaction. This review summarizes the current scenario of NMD-mediated viral RNA degradation and classifies various molecular means by which viruses compromise the NMD-mediated antiviral defense for better infection in their hosts. |
| first_indexed | 2024-03-11T04:26:53Z |
| format | Article |
| id | doaj.art-21517957e47946eeaedfd538c5c1969c |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T04:26:53Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-21517957e47946eeaedfd538c5c1969c2023-11-17T21:44:11ZengMDPI AGViruses1999-49152023-03-0115481610.3390/v15040816Molecular Interaction of Nonsense-Mediated mRNA Decay with VirusesMd Robel Ahmed0Zhiyou Du1College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, ChinaCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, ChinaThe virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses. One of the host antiviral defenses is the nonsense-mediated mRNA decay (NMD), an evolutionarily conserved mechanism for RNA quality control in eukaryotic cells. NMD ensures the accuracy of mRNA translation by removing the abnormal mRNAs harboring pre-matured stop codons. Many RNA viruses have a genome that contains internal stop codon(s) (iTC). Akin to the premature termination codon in aberrant RNA transcripts, the presence of iTC would activate NMD to degrade iTC-containing viral genomes. A couple of viruses have been reported to be sensitive to the NMD-mediated antiviral defense, while some viruses have evolved with specific <i>cis</i>-acting RNA features or <i>trans</i>-acting viral proteins to overcome or escape from NMD. Recently, increasing light has been shed on the NMD–virus interaction. This review summarizes the current scenario of NMD-mediated viral RNA degradation and classifies various molecular means by which viruses compromise the NMD-mediated antiviral defense for better infection in their hosts.https://www.mdpi.com/1999-4915/15/4/816nonsense-mediated mRNA decay (NMD)RNA virushost–virus interaction |
| spellingShingle | Md Robel Ahmed Zhiyou Du Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses Viruses nonsense-mediated mRNA decay (NMD) RNA virus host–virus interaction |
| title | Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses |
| title_full | Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses |
| title_fullStr | Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses |
| title_full_unstemmed | Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses |
| title_short | Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses |
| title_sort | molecular interaction of nonsense mediated mrna decay with viruses |
| topic | nonsense-mediated mRNA decay (NMD) RNA virus host–virus interaction |
| url | https://www.mdpi.com/1999-4915/15/4/816 |
| work_keys_str_mv | AT mdrobelahmed molecularinteractionofnonsensemediatedmrnadecaywithviruses AT zhiyoudu molecularinteractionofnonsensemediatedmrnadecaywithviruses |