Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum
Information on the relationship between the exposure concentrations of metals and their biodistribution among organs remained scarce in invertebrates. The objective of this study was to investigate the effects of Cd concentration on the organotropism, toxico-kinetic and fate of this metal in differe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022006006 |
| _version_ | 1797948295375486976 |
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| author | Ophélia Gestin Thomas Lacoue-Labarthe Nicolas Delorme Laura Garnero Olivier Geffard Christelle Lopes |
| author_facet | Ophélia Gestin Thomas Lacoue-Labarthe Nicolas Delorme Laura Garnero Olivier Geffard Christelle Lopes |
| author_sort | Ophélia Gestin |
| collection | DOAJ |
| description | Information on the relationship between the exposure concentrations of metals and their biodistribution among organs remained scarce in invertebrates. The objective of this study was to investigate the effects of Cd concentration on the organotropism, toxico-kinetic and fate of this metal in different organs of gammarids exposed to dissolved radioisotope 109Cd. Gammarids male were exposed for 7 days to three environmental Cd concentrations (i.e. 4, 52 and 350 ng.L−1) before being placed in depuration conditions (i.e. uncontaminated water). At several sampling times, Cd concentrations were determined by 109Cd γ-counting in water, caeca, cephalon, gills, intestine and remaining tissues. Bioconcentration Factors (BCF) and Cd relative proportions in organs were calculated to assess the exposure concentration effect on the bioaccumulation capacities. The dependance of the organ-specific kinetic parameters to Cd water concentrations were estimated by fitting nested one-compartment toxico-kinetic (TK) models to both the accumulation and depuration data, by Bayesian inference. Then, for each Cd concentrations, the metal exchanges among organs over time were formalized by a multi-compartments TK model fitted to all organ data simultaneously. Our results highlighted that, at the end of the exposure phase, BCF and Cd relative proportions, in each organ, were not significantly modulated by water concentrations. Kinetically, Cd accumulation rates in all organs (except intestines) were depended on the exposure concentration, but not the elimination rates. The in vivo management of Cd (i.e. metal exchanges among organs) remained qualitatively unchanged according to exposure concentration. All these results also highlighted key role of that organs in the management of Cd: bioconcentration by caeca, storage by gills and main entry pathway by intestine. This study shows the interest of implementing TK approaches to test the effect of environmental factors on bioaccumulation, inter-organ exchanges and fate of contaminants in invertebrate body to enhance the understanding of the toxicity risk. |
| first_indexed | 2024-04-10T21:41:06Z |
| format | Article |
| id | doaj.art-2151fa9f05ce4befaed43132cb0b4843 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-10T21:41:06Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-2151fa9f05ce4befaed43132cb0b48432023-01-19T04:16:10ZengElsevierEnvironment International0160-41202023-01-01171107673Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarumOphélia Gestin0Thomas Lacoue-Labarthe1Nicolas Delorme2Laura Garnero3Olivier Geffard4Christelle Lopes5Univ Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, 69622 Villeurbanne, France; Littoral Environnement et Sociétés (LIENSs), UMR 7266 CNRS - Université de la Rochelle, 2, rue Olympe de Gouges, 17000 La Rochelle, France; INRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceLittoral Environnement et Sociétés (LIENSs), UMR 7266 CNRS - Université de la Rochelle, 2, rue Olympe de Gouges, 17000 La Rochelle, FranceINRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceINRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceINRAE, RiverLy, Ecotoxicology Laboratory, 5 Avenue de la Doua, CS20244, 69625 Villeurbanne Cedex, FranceUniv Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, 69622 Villeurbanne, France; Corresponding author at: Laboratoire de Biométrie et Biologie Évolutive UM R5558, Université Lyon 1 (CNRS), 69622 Villeurbanne, France.Information on the relationship between the exposure concentrations of metals and their biodistribution among organs remained scarce in invertebrates. The objective of this study was to investigate the effects of Cd concentration on the organotropism, toxico-kinetic and fate of this metal in different organs of gammarids exposed to dissolved radioisotope 109Cd. Gammarids male were exposed for 7 days to three environmental Cd concentrations (i.e. 4, 52 and 350 ng.L−1) before being placed in depuration conditions (i.e. uncontaminated water). At several sampling times, Cd concentrations were determined by 109Cd γ-counting in water, caeca, cephalon, gills, intestine and remaining tissues. Bioconcentration Factors (BCF) and Cd relative proportions in organs were calculated to assess the exposure concentration effect on the bioaccumulation capacities. The dependance of the organ-specific kinetic parameters to Cd water concentrations were estimated by fitting nested one-compartment toxico-kinetic (TK) models to both the accumulation and depuration data, by Bayesian inference. Then, for each Cd concentrations, the metal exchanges among organs over time were formalized by a multi-compartments TK model fitted to all organ data simultaneously. Our results highlighted that, at the end of the exposure phase, BCF and Cd relative proportions, in each organ, were not significantly modulated by water concentrations. Kinetically, Cd accumulation rates in all organs (except intestines) were depended on the exposure concentration, but not the elimination rates. The in vivo management of Cd (i.e. metal exchanges among organs) remained qualitatively unchanged according to exposure concentration. All these results also highlighted key role of that organs in the management of Cd: bioconcentration by caeca, storage by gills and main entry pathway by intestine. This study shows the interest of implementing TK approaches to test the effect of environmental factors on bioaccumulation, inter-organ exchanges and fate of contaminants in invertebrate body to enhance the understanding of the toxicity risk.http://www.sciencedirect.com/science/article/pii/S0160412022006006Concentration-dependenciesAmphipodsMetalOne-compartmentMulti-compartmentsBayesian Inference |
| spellingShingle | Ophélia Gestin Thomas Lacoue-Labarthe Nicolas Delorme Laura Garnero Olivier Geffard Christelle Lopes Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum Environment International Concentration-dependencies Amphipods Metal One-compartment Multi-compartments Bayesian Inference |
| title | Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum |
| title_full | Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum |
| title_fullStr | Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum |
| title_full_unstemmed | Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum |
| title_short | Influence of the exposure concentration of dissolved cadmium on its organotropism, toxicokinetic and fate in Gammarus fossarum |
| title_sort | influence of the exposure concentration of dissolved cadmium on its organotropism toxicokinetic and fate in gammarus fossarum |
| topic | Concentration-dependencies Amphipods Metal One-compartment Multi-compartments Bayesian Inference |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022006006 |
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