The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms
Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized collectively by clonal proliferation of myeloid cells with variable morphologic maturity and hematopoietic efficiency. Although the natural history of these neoplasms can be measured sometimes in decades more than years...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/8/813 |
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| author | Giuseppe Lanzarone Matteo Olivi |
| author_facet | Giuseppe Lanzarone Matteo Olivi |
| author_sort | Giuseppe Lanzarone |
| collection | DOAJ |
| description | Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized collectively by clonal proliferation of myeloid cells with variable morphologic maturity and hematopoietic efficiency. Although the natural history of these neoplasms can be measured sometimes in decades more than years, the cytogenetics analysis can offer useful information regarding the prognosis. Cytogenetics has a well-established prognostic role in acute leukemias and in myelodysplastic syndromes, where it drives the clinical decisions. NGS techniques can find adverse mutations with clear prognostic value and are currently included in the prognostic evaluation of MPNs in scores such as MIPSS, GIPSS, MIPSS-PV, and MIPSS-ET. We suggest that cytogenetics (considering its availability and relative cost) has a role regarding prognostic and therapeutic decisions. |
| first_indexed | 2024-03-10T08:36:48Z |
| format | Article |
| id | doaj.art-21527cdcfca4414c989427674b41270e |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T08:36:48Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-21527cdcfca4414c989427674b41270e2023-11-22T08:36:29ZengMDPI AGMedicina1010-660X1648-91442021-08-0157881310.3390/medicina57080813The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative NeoplasmsGiuseppe Lanzarone0Matteo Olivi1Unit of Hematology, Department of Oncology, University of Torino, 10126 Turin, ItalyUnit of Hematology, Department of Oncology, University of Torino, 10126 Turin, ItalyMyeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized collectively by clonal proliferation of myeloid cells with variable morphologic maturity and hematopoietic efficiency. Although the natural history of these neoplasms can be measured sometimes in decades more than years, the cytogenetics analysis can offer useful information regarding the prognosis. Cytogenetics has a well-established prognostic role in acute leukemias and in myelodysplastic syndromes, where it drives the clinical decisions. NGS techniques can find adverse mutations with clear prognostic value and are currently included in the prognostic evaluation of MPNs in scores such as MIPSS, GIPSS, MIPSS-PV, and MIPSS-ET. We suggest that cytogenetics (considering its availability and relative cost) has a role regarding prognostic and therapeutic decisions.https://www.mdpi.com/1648-9144/57/8/813myeloproliferative neoplasmscytogeneticsprognosis |
| spellingShingle | Giuseppe Lanzarone Matteo Olivi The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms Medicina myeloproliferative neoplasms cytogenetics prognosis |
| title | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
| title_full | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
| title_fullStr | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
| title_full_unstemmed | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
| title_short | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
| title_sort | prognostic role of cytogenetics analysis in philadelphia negative myeloproliferative neoplasms |
| topic | myeloproliferative neoplasms cytogenetics prognosis |
| url | https://www.mdpi.com/1648-9144/57/8/813 |
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