Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion
BackgroundThe association between tumor location and breast cancer prognosis has been controversial. We sought to explore the relationship between tumors located in central and nipple portion (TCNP) and Chinese breast cancer.Patients and methodsA total of 1,427 breast cancer patients were recruited....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.993263/full |
| _version_ | 1818024277250670592 |
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| author | Wei-Da Fu Xiao-Hui Wang Kang-Kang Lu Yi-Qiao Lu Jie-Yu Zhou Qi-Di Huang Gui-Long Guo |
| author_facet | Wei-Da Fu Xiao-Hui Wang Kang-Kang Lu Yi-Qiao Lu Jie-Yu Zhou Qi-Di Huang Gui-Long Guo |
| author_sort | Wei-Da Fu |
| collection | DOAJ |
| description | BackgroundThe association between tumor location and breast cancer prognosis has been controversial. We sought to explore the relationship between tumors located in central and nipple portion (TCNP) and Chinese breast cancer.Patients and methodsA total of 1,427 breast cancer patients were recruited. There were 328 cases of TCNP and 1,099 cases of tumors in the breast peripheral quadrant (TBPQ). The chi-square test was used to compare different variables between TCNP and TBPQ groups. A one-to-one propensity score matching (PSM) was applied to construct a matched sample consisting of pairs of TCNP and TBPQ groups. Kaplan–Meier curves were used for survival analysis of disease-free survival (DFS), breast cancer-specific survival (BCSS) and overall survival (OS). The Cox proportional hazards regression model was applied to identify prognostic risk factors.ResultsThe median follow-up time was 58 months. Compared to TBPQ, TCNP patients had significantly larger tumor size, more frequent metastasis to lymph nodes (LN) and more proportions of TNM stage II–III. DFS, OS and BCSS rates were markedly lower in the TCNP group as compared to the TBPQ group before and after PSM (all p < 0.05). Multivariate Cox analysis showed that TCNP was an independent prognostic factor for breast cancer. Subgroup analysis indicated that for breast molecular subtypes and TNM stage II-III breast cancer, TCNP were related to worse prognosis. Multivariate logistic regression revealed that TCNP was an independent contributing factor for LN metastasis.ConclusionIn Chinese breast cancer, compared to TBPQ, TCNP is associated with more LN metastasis and poorer prognosis. |
| first_indexed | 2024-12-10T03:57:39Z |
| format | Article |
| id | doaj.art-2154d084f8ce4d07b96e57ccb76dbd91 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-12-10T03:57:39Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-2154d084f8ce4d07b96e57ccb76dbd912022-12-22T02:03:03ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-10-01910.3389/fsurg.2022.993263993263Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portionWei-Da Fu0Xiao-Hui Wang1Kang-Kang Lu2Yi-Qiao Lu3Jie-Yu Zhou4Qi-Di Huang5Gui-Long Guo6Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Breast / Thyroid Surgery, Jinhua Municipal Central Hospital, Jinhua, ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaBackgroundThe association between tumor location and breast cancer prognosis has been controversial. We sought to explore the relationship between tumors located in central and nipple portion (TCNP) and Chinese breast cancer.Patients and methodsA total of 1,427 breast cancer patients were recruited. There were 328 cases of TCNP and 1,099 cases of tumors in the breast peripheral quadrant (TBPQ). The chi-square test was used to compare different variables between TCNP and TBPQ groups. A one-to-one propensity score matching (PSM) was applied to construct a matched sample consisting of pairs of TCNP and TBPQ groups. Kaplan–Meier curves were used for survival analysis of disease-free survival (DFS), breast cancer-specific survival (BCSS) and overall survival (OS). The Cox proportional hazards regression model was applied to identify prognostic risk factors.ResultsThe median follow-up time was 58 months. Compared to TBPQ, TCNP patients had significantly larger tumor size, more frequent metastasis to lymph nodes (LN) and more proportions of TNM stage II–III. DFS, OS and BCSS rates were markedly lower in the TCNP group as compared to the TBPQ group before and after PSM (all p < 0.05). Multivariate Cox analysis showed that TCNP was an independent prognostic factor for breast cancer. Subgroup analysis indicated that for breast molecular subtypes and TNM stage II-III breast cancer, TCNP were related to worse prognosis. Multivariate logistic regression revealed that TCNP was an independent contributing factor for LN metastasis.ConclusionIn Chinese breast cancer, compared to TBPQ, TCNP is associated with more LN metastasis and poorer prognosis.https://www.frontiersin.org/articles/10.3389/fsurg.2022.993263/fullbreast cancertumors located in central and nipple portionstumors in the breast peripheral quadrantlymph nodes metastasisprognosis |
| spellingShingle | Wei-Da Fu Xiao-Hui Wang Kang-Kang Lu Yi-Qiao Lu Jie-Yu Zhou Qi-Di Huang Gui-Long Guo Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion Frontiers in Surgery breast cancer tumors located in central and nipple portions tumors in the breast peripheral quadrant lymph nodes metastasis prognosis |
| title | Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion |
| title_full | Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion |
| title_fullStr | Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion |
| title_full_unstemmed | Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion |
| title_short | Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion |
| title_sort | real world outcomes for chinese breast cancer patients with tumor location of central and nipple portion |
| topic | breast cancer tumors located in central and nipple portions tumors in the breast peripheral quadrant lymph nodes metastasis prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.993263/full |
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