Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci

Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci

LINE-1 (L1) retrotransposons represent approximately one sixth of the human genome, but only the human-specific L1HS-Ta subfamily acts as an endogenous mutagen in modern humans, reshaping both somatic and germline genomes. Due to their high levels of sequence identity and the existence of many polym...

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Bibliographic Details
Main Authors: Claude Philippe, Dulce B Vargas-Landin, Aurélien J Doucet, Dominic van Essen, Jorge Vera-Otarola, Monika Kuciak, Antoine Corbin, Pilvi Nigumann, Gaël Cristofari
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
transposable element
retrotransposon
LINE-1
genome instability
transposon
L1
Online Access:https://elifesciences.org/articles/13926

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