Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia
Objectives: Coronary artery ectasia (CAE) has been defined as a dilated artery luminal diameter that is at least 50% greater than the diameter of the normal portion of the artery. Isolated CAE is defined as CAE without significant coronary artery stenosis and isolated CAE has more pronounced inflam...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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KARE Publishing
2013-04-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-17003 |
| _version_ | 1797917849053822976 |
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| author | Turgay Isik Erkan Ayhan Hüseyin Uyarel İbrahim Halil Tanboğa Mustafa Kurt Mahmut Uluganyan Mehmet Ergelen Abdurrahman Eksik |
| author_facet | Turgay Isik Erkan Ayhan Hüseyin Uyarel İbrahim Halil Tanboğa Mustafa Kurt Mahmut Uluganyan Mehmet Ergelen Abdurrahman Eksik |
| author_sort | Turgay Isik |
| collection | DOAJ |
| description | Objectives: Coronary artery ectasia (CAE) has been defined as a dilated artery luminal diameter that is at least 50% greater than the diameter of the normal portion of the artery. Isolated CAE is defined as CAE without significant coronary artery stenosis and isolated CAE has more pronounced inflammatory symptoms. Neutrophil to lymphocyte ratio (NLR) is widely used as a marker of inflammation and an indicator of cardiovascular outcomes in patients with coronary artery disease. We examined a possible association between NLR and the presence of isolated CAE.
Study design: In this study, 2345 patients who underwent coronary angiography for suspected or known ischemic heart disease were evaluated retrospectively. Following the application of exclusion criteria, our study population consisted of 81 CAE patients and 85 age- and gender-matched subjects who proved to have normal coronary angiograms. Baseline neutrophil, lymphocyte and other hematologic indices were measured routinely prior to the coronary angiography.
Results: Patients with angiographic isolated CAE had significantly elevated NLR when compared to the patients with normal coronary artery pathology (3.39+-1.36 vs. 2.25+-0.58, p<0.001). A NLR level ≥2.37 measured on admission had a 77% sensitivity and 63% specificity in predicting isolated CAE at ROC curve analysis. In the multivariate analysis, hypercholesterolemia (OR=2.63, 95% CI 1.22-5.65, p=0.01), obesity (OR=3.76, 95% CI 1.43-9.87, p=0.007) and increased NLR (OR=6.03, 95% CI 2.61-13.94, p<0.001) were independent predictors for the presence of isolated CAE.
Conclusion: Neutrophil to lymphocyte ratio is a readily available clinical laboratory value that is associated with the presence of isolated CAE. |
| first_indexed | 2024-04-10T13:19:54Z |
| format | Article |
| id | doaj.art-215840c1fed348ae82bd8f3af506af22 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T13:19:54Z |
| publishDate | 2013-04-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-215840c1fed348ae82bd8f3af506af222023-02-15T16:12:05ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692013-04-0141212313010.5543/tkda.2013.17003TKDA-17003Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasiaTurgay Isik0Erkan Ayhan1Hüseyin Uyarel2İbrahim Halil Tanboğa3Mustafa Kurt4Mahmut Uluganyan5Mehmet Ergelen6Abdurrahman Eksik7Department Of Cardiology, Balikesir University, School Of Medicine, Balikesir, TurkeyDepartment Of Cardiology, Balikesir University, School Of Medicine, Balikesir, TurkeyDepartment Of Cardiology, Bezmialem Vakif University, Faculty Of Medicine, Istanbul, TurkeyDepartment Of Cardiology, Erzurum Education And Research Hospital, Erzurum, TurkeyDepartment Of Cardiology, Erzurum Education And Research Hospital, Erzurum, TurkeyDepartment of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Istanbul, TurkeyDepartment Of Cardiology, Bezmialem Vakif University, Faculty Of Medicine, Istanbul, TurkeyDepartment of Cardiology, Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Istanbul, TurkeyObjectives: Coronary artery ectasia (CAE) has been defined as a dilated artery luminal diameter that is at least 50% greater than the diameter of the normal portion of the artery. Isolated CAE is defined as CAE without significant coronary artery stenosis and isolated CAE has more pronounced inflammatory symptoms. Neutrophil to lymphocyte ratio (NLR) is widely used as a marker of inflammation and an indicator of cardiovascular outcomes in patients with coronary artery disease. We examined a possible association between NLR and the presence of isolated CAE. Study design: In this study, 2345 patients who underwent coronary angiography for suspected or known ischemic heart disease were evaluated retrospectively. Following the application of exclusion criteria, our study population consisted of 81 CAE patients and 85 age- and gender-matched subjects who proved to have normal coronary angiograms. Baseline neutrophil, lymphocyte and other hematologic indices were measured routinely prior to the coronary angiography. Results: Patients with angiographic isolated CAE had significantly elevated NLR when compared to the patients with normal coronary artery pathology (3.39+-1.36 vs. 2.25+-0.58, p<0.001). A NLR level ≥2.37 measured on admission had a 77% sensitivity and 63% specificity in predicting isolated CAE at ROC curve analysis. In the multivariate analysis, hypercholesterolemia (OR=2.63, 95% CI 1.22-5.65, p=0.01), obesity (OR=3.76, 95% CI 1.43-9.87, p=0.007) and increased NLR (OR=6.03, 95% CI 2.61-13.94, p<0.001) were independent predictors for the presence of isolated CAE. Conclusion: Neutrophil to lymphocyte ratio is a readily available clinical laboratory value that is associated with the presence of isolated CAE.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-17003coronary angiographycoronary vessel anomalies/ complications; coronary vessels/pathology; neutrophils; lymphocytes; dilatationpathologic. |
| spellingShingle | Turgay Isik Erkan Ayhan Hüseyin Uyarel İbrahim Halil Tanboğa Mustafa Kurt Mahmut Uluganyan Mehmet Ergelen Abdurrahman Eksik Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia Türk Kardiyoloji Derneği Arşivi coronary angiography coronary vessel anomalies/ complications; coronary vessels/pathology; neutrophils; lymphocytes; dilatation pathologic. |
| title | Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia |
| title_full | Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia |
| title_fullStr | Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia |
| title_full_unstemmed | Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia |
| title_short | Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia |
| title_sort | association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia |
| topic | coronary angiography coronary vessel anomalies/ complications; coronary vessels/pathology; neutrophils; lymphocytes; dilatation pathologic. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-17003 |
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