The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis

The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis

The with-no-lysine (WNK) kinase family, comprising four serine-threonine protein kinases (WNK1-4), were first linked to hypertension due to their mutations in association with pseudohypoaldosteronism type II (PHAII). WNK kinases regulate crucial blood pressure regulators, SPAK/OSR1, to mediate the p...

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Bibliographic Details
Main Authors: Shiuan-Chen Lin, Chun Ma, Kao-Jung Chang, Han-Ping Cheong, Ming-Cheng Lee, Yuan-Tzu Lan, Chien-Ying Wang, Shih-Hwa Chiou, Teh-Ia Huo, Tsui-Kang Hsu, Ping-Hsing Tsai, Yi-Ping Yang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biomedicines
Subjects:
WNK kinase
post-translational modifications
blood pressure regulation
NCC
NKCCs
ROMK
Online Access:https://www.mdpi.com/2227-9059/10/9/2169

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