Recent Advances of Degradation Technologies Based on PROTAC Mechanism
PROTAC (proteolysis-targeting chimeras), which selectively degrades target proteins, has become the most popular technology for drug development in recent years. Here, we introduce the history of PROTAC, and summarize the recent advances in novel types of degradation technologies based on the PROTAC...
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Format: | Article |
Language: | English |
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MDPI AG
2022-09-01
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Series: | Biomolecules |
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Online Access: | https://www.mdpi.com/2218-273X/12/9/1257 |
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author | Mingchao Xiao Jiaojiao Zhao Qiang Wang Jia Liu Leina Ma |
author_facet | Mingchao Xiao Jiaojiao Zhao Qiang Wang Jia Liu Leina Ma |
author_sort | Mingchao Xiao |
collection | DOAJ |
description | PROTAC (proteolysis-targeting chimeras), which selectively degrades target proteins, has become the most popular technology for drug development in recent years. Here, we introduce the history of PROTAC, and summarize the recent advances in novel types of degradation technologies based on the PROTAC mechanism, including TF-PROTAC, Light-controllable PROTAC, PhosphoTAC, LYTAC, AUTAC, ATTEC, CMA, RNA-PROTAC and RIBOTACs. In addition, the clinical progress, current challenges and future prospects of degradation technologies based on PROTAC mechanism are discussed. |
first_indexed | 2024-03-10T00:36:06Z |
format | Article |
id | doaj.art-21590cf747ed4d1c9922f39f1b03f61f |
institution | Directory Open Access Journal |
issn | 2218-273X |
language | English |
last_indexed | 2024-03-10T00:36:06Z |
publishDate | 2022-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Biomolecules |
spelling | doaj.art-21590cf747ed4d1c9922f39f1b03f61f2023-11-23T15:15:35ZengMDPI AGBiomolecules2218-273X2022-09-01129125710.3390/biom12091257Recent Advances of Degradation Technologies Based on PROTAC MechanismMingchao Xiao0Jiaojiao Zhao1Qiang Wang2Jia Liu3Leina Ma4Cancer Institute of The Affiliated Hospital, Qingdao University, Qingdao 266071, ChinaCancer Institute of The Affiliated Hospital, Qingdao University, Qingdao 266071, ChinaOncology Department, Shandong Second Provincial General Hospital, Jinan 250022, ChinaDepartment of Pharmacology, School of Pharmacy, Qingdao University, Qingdao 266071, ChinaCancer Institute of The Affiliated Hospital, Qingdao University, Qingdao 266071, ChinaPROTAC (proteolysis-targeting chimeras), which selectively degrades target proteins, has become the most popular technology for drug development in recent years. Here, we introduce the history of PROTAC, and summarize the recent advances in novel types of degradation technologies based on the PROTAC mechanism, including TF-PROTAC, Light-controllable PROTAC, PhosphoTAC, LYTAC, AUTAC, ATTEC, CMA, RNA-PROTAC and RIBOTACs. In addition, the clinical progress, current challenges and future prospects of degradation technologies based on PROTAC mechanism are discussed.https://www.mdpi.com/2218-273X/12/9/1257proteolysis-targeting chimerasprotein degradation technologyE3 ligaseprotein of interest |
spellingShingle | Mingchao Xiao Jiaojiao Zhao Qiang Wang Jia Liu Leina Ma Recent Advances of Degradation Technologies Based on PROTAC Mechanism Biomolecules proteolysis-targeting chimeras protein degradation technology E3 ligase protein of interest |
title | Recent Advances of Degradation Technologies Based on PROTAC Mechanism |
title_full | Recent Advances of Degradation Technologies Based on PROTAC Mechanism |
title_fullStr | Recent Advances of Degradation Technologies Based on PROTAC Mechanism |
title_full_unstemmed | Recent Advances of Degradation Technologies Based on PROTAC Mechanism |
title_short | Recent Advances of Degradation Technologies Based on PROTAC Mechanism |
title_sort | recent advances of degradation technologies based on protac mechanism |
topic | proteolysis-targeting chimeras protein degradation technology E3 ligase protein of interest |
url | https://www.mdpi.com/2218-273X/12/9/1257 |
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