Single nucleotide polymorphism (SNP) in genes of lupus: A Philippine study (SIGLA‐PH)
Abstract Background Systemic lupus erythematosus (SLE) is a complex prototypic autoimmune disease, with a prevalence of 20–150 per 100,000, most commonly affecting women at child‐bearing age. Genome‐wide association studies and fine mapping of candidate regions have paved the way for greater underst...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Rheumatology & Autoimmunity |
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| Online Access: | https://doi.org/10.1002/rai2.12024 |
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| author | Michael L. Tee Cherica A. Tee Jose B. Nevado Jr. Angeline Therese Santiago Aedrian A. Abrilla Carlo M. Lapid Francis A. Tablizo Joshua A. Dizon El K. B. Morado Eva Maria Cutiongco‐Dela Paz |
| author_facet | Michael L. Tee Cherica A. Tee Jose B. Nevado Jr. Angeline Therese Santiago Aedrian A. Abrilla Carlo M. Lapid Francis A. Tablizo Joshua A. Dizon El K. B. Morado Eva Maria Cutiongco‐Dela Paz |
| author_sort | Michael L. Tee |
| collection | DOAJ |
| description | Abstract Background Systemic lupus erythematosus (SLE) is a complex prototypic autoimmune disease, with a prevalence of 20–150 per 100,000, most commonly affecting women at child‐bearing age. Genome‐wide association studies and fine mapping of candidate regions have paved the way for greater understanding of SLE as a disease of genetic–environmental susceptibility and the functions of the genes involved. Method This study was conducted to determine the association of selected single nucleotide polymorphisms (SNPs) from established genomic databases based on theoretical risk and protective odds ratios > 2.5 or <0.40) to susceptibility of developing SLE among Filipinos. Results We analyzed data from 310 SLE patients and 318 controls. We identified eight significant SNPs namely rs9271100, rs9271366, rs9272105, rs9275328, rs2647087, rs12734338, rs17885098, and rs3883013 to be associated with an increased risk of developing SLE among Filipinos. Conclusion Eight SNPs were found to be associated with the development of SLE among Filipinos. Similar to previous genetic studies in lupus patients, majority of the SNPs were found in the major histocompatibilty complex genes in the HLA region. Our study identified two unique SNPs that will be validated as potential diagnostic markers for SLE. The findings of this study may contribute to the development of a polygenic risk score in determining susceptibility to SLE among Filipinos. |
| first_indexed | 2024-12-10T11:12:42Z |
| format | Article |
| id | doaj.art-215a30019bc646fe881ac4ea0308de72 |
| institution | Directory Open Access Journal |
| issn | 2767-1429 |
| language | English |
| last_indexed | 2024-12-10T11:12:42Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Rheumatology & Autoimmunity |
| spelling | doaj.art-215a30019bc646fe881ac4ea0308de722022-12-22T01:51:20ZengWileyRheumatology & Autoimmunity2767-14292022-03-0121223010.1002/rai2.12024Single nucleotide polymorphism (SNP) in genes of lupus: A Philippine study (SIGLA‐PH)Michael L. Tee0Cherica A. Tee1Jose B. Nevado Jr.2Angeline Therese Santiago3Aedrian A. Abrilla4Carlo M. Lapid5Francis A. Tablizo6Joshua A. Dizon7El K. B. Morado8Eva Maria Cutiongco‐Dela Paz9College of Medicine University of the Philippines Manila Manila PhillipinesCollege of Medicine University of the Philippines Manila Manila PhillipinesInstitute of Human Genetics, National Institutes of Health University of the Philippines Manila Manila PhillipinesCollege of Medicine University of the Philippines Manila Manila PhillipinesCollege of Medicine and Philippine General Hospital University of the Philippines Manila Manila PhillipinesInstitute of Human Genetics, National Institutes of Health University of the Philippines Manila Manila PhillipinesInstitute of Human Genetics, National Institutes of Health University of the Philippines Manila Manila PhillipinesInstitute of Human Genetics, National Institutes of Health University of the Philippines Manila Manila PhillipinesInstitute of Human Genetics, National Institutes of Health University of the Philippines Manila Manila PhillipinesNational Institutes of Health University of the Philippines Manila Manila PhillipinesAbstract Background Systemic lupus erythematosus (SLE) is a complex prototypic autoimmune disease, with a prevalence of 20–150 per 100,000, most commonly affecting women at child‐bearing age. Genome‐wide association studies and fine mapping of candidate regions have paved the way for greater understanding of SLE as a disease of genetic–environmental susceptibility and the functions of the genes involved. Method This study was conducted to determine the association of selected single nucleotide polymorphisms (SNPs) from established genomic databases based on theoretical risk and protective odds ratios > 2.5 or <0.40) to susceptibility of developing SLE among Filipinos. Results We analyzed data from 310 SLE patients and 318 controls. We identified eight significant SNPs namely rs9271100, rs9271366, rs9272105, rs9275328, rs2647087, rs12734338, rs17885098, and rs3883013 to be associated with an increased risk of developing SLE among Filipinos. Conclusion Eight SNPs were found to be associated with the development of SLE among Filipinos. Similar to previous genetic studies in lupus patients, majority of the SNPs were found in the major histocompatibilty complex genes in the HLA region. Our study identified two unique SNPs that will be validated as potential diagnostic markers for SLE. The findings of this study may contribute to the development of a polygenic risk score in determining susceptibility to SLE among Filipinos.https://doi.org/10.1002/rai2.12024geneticslupusSLESNPsusceptibility |
| spellingShingle | Michael L. Tee Cherica A. Tee Jose B. Nevado Jr. Angeline Therese Santiago Aedrian A. Abrilla Carlo M. Lapid Francis A. Tablizo Joshua A. Dizon El K. B. Morado Eva Maria Cutiongco‐Dela Paz Single nucleotide polymorphism (SNP) in genes of lupus: A Philippine study (SIGLA‐PH) Rheumatology & Autoimmunity genetics lupus SLE SNP susceptibility |
| title | Single nucleotide polymorphism (SNP) in genes of lupus: A Philippine study (SIGLA‐PH) |
| title_full | Single nucleotide polymorphism (SNP) in genes of lupus: A Philippine study (SIGLA‐PH) |
| title_fullStr | Single nucleotide polymorphism (SNP) in genes of lupus: A Philippine study (SIGLA‐PH) |
| title_full_unstemmed | Single nucleotide polymorphism (SNP) in genes of lupus: A Philippine study (SIGLA‐PH) |
| title_short | Single nucleotide polymorphism (SNP) in genes of lupus: A Philippine study (SIGLA‐PH) |
| title_sort | single nucleotide polymorphism snp in genes of lupus a philippine study sigla ph |
| topic | genetics lupus SLE SNP susceptibility |
| url | https://doi.org/10.1002/rai2.12024 |
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