MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

MicroRNAs (miRNAs), in association with Argonaute (AGO) proteins, direct repression by pairing to sites within mRNAs. Compared to pairing preferences of the miRNA seed region (nucleotides 2–8), preferences of the miRNA 3′ region are poorly understood, due to the sparsity of measured affinities for t...

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Bibliographic Details
Main Authors: Sean E McGeary, Namita Bisaria, Thy M Pham, Peter Y Wang, David P Bartel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
miRNA
argonaute
RISC
post-transcriptional gene regulation
high-throughput biochemistry
RBNS
Online Access:https://elifesciences.org/articles/69803

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