A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma

A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma

Abstract Background Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the development of effective treatment strategies are urgent. Methods RNA s...

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Bibliographic Details
Main Authors: Tong Tong, Xing Qin, Yingying Jiang, Haiyan Guo, Xiaoning Wang, Yan Li, Fei Xie, Hao Lu, Peisong Zhai, Hailong Ma, Jianjun Zhang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Medicine
Subjects:
HNSCC
Cisplatin resistance
Mitochondrial apoptosis
CREB5
TOP1MT
Online Access:https://doi.org/10.1186/s12916-022-02409-x

Internet

https://doi.org/10.1186/s12916-022-02409-x

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