Preliminary toxicological assessment of heated tobacco products: A review of the literature and proposed strategy
Heated tobacco products (HTP) have become increasingly common in many countries worldwide. The principle of heating tobacco, without combustion, to produce a nicotine-containing aerosol with remarkably reduced levels of other known toxins, compared to combusted tobacco cigarettes, is now well establ...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750023000082 |
| _version_ | 1797798856779366400 |
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| author | Ruth Dempsey Gregory Rodrigo Florence Vonmoos Irfan Gunduz Maxim Belushkin Marco Esposito |
| author_facet | Ruth Dempsey Gregory Rodrigo Florence Vonmoos Irfan Gunduz Maxim Belushkin Marco Esposito |
| author_sort | Ruth Dempsey |
| collection | DOAJ |
| description | Heated tobacco products (HTP) have become increasingly common in many countries worldwide. The principle of heating tobacco, without combustion, to produce a nicotine-containing aerosol with remarkably reduced levels of other known toxins, compared to combusted tobacco cigarettes, is now well established. As these products are intended as alternatives to traditional combusted products, during the early stages of their development, it is important for manufacturers to ensure that the design of the product does not lead to any unintentionally increased or new risk for the consumer, compared to the traditional products that consumers seek to replace. There is limited guidance from tobacco product regulations concerning the requirements for performing such preliminary toxicological assessments. Here, we review the published literature on studies performed on HTPs in the pursuit of such data, outline a proposed approach that is consistent with regulatory requirements, and provide a logical approach to the preliminary toxicological assessment of HTPs. |
| first_indexed | 2024-03-13T04:10:55Z |
| format | Article |
| id | doaj.art-215ebd7bc838441b91cc28a785ff4907 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-03-13T04:10:55Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-215ebd7bc838441b91cc28a785ff49072023-06-21T06:55:02ZengElsevierToxicology Reports2214-75002023-01-0110195205Preliminary toxicological assessment of heated tobacco products: A review of the literature and proposed strategyRuth Dempsey0Gregory Rodrigo1Florence Vonmoos2Irfan Gunduz3Maxim Belushkin4Marco Esposito5RD Science Speaks Consultancy Sàrl, Le Mont sur Lausanne, Switzerland; Corresponding authors.PMI R&D, Philip Morris Products S.A., Rue des Usines 56, 2000 Neuchâtel, Switzerland; Corresponding authors.PMI R&D, Philip Morris Products S.A., Rue des Usines 56, 2000 Neuchâtel, SwitzerlandPMI R&D, Philip Morris Products S.A., Rue des Usines 56, 2000 Neuchâtel, SwitzerlandPMI R&D, Philip Morris Products S.A., Rue des Usines 56, 2000 Neuchâtel, SwitzerlandPMI R&D, Philip Morris Products S.A., Rue des Usines 56, 2000 Neuchâtel, SwitzerlandHeated tobacco products (HTP) have become increasingly common in many countries worldwide. The principle of heating tobacco, without combustion, to produce a nicotine-containing aerosol with remarkably reduced levels of other known toxins, compared to combusted tobacco cigarettes, is now well established. As these products are intended as alternatives to traditional combusted products, during the early stages of their development, it is important for manufacturers to ensure that the design of the product does not lead to any unintentionally increased or new risk for the consumer, compared to the traditional products that consumers seek to replace. There is limited guidance from tobacco product regulations concerning the requirements for performing such preliminary toxicological assessments. Here, we review the published literature on studies performed on HTPs in the pursuit of such data, outline a proposed approach that is consistent with regulatory requirements, and provide a logical approach to the preliminary toxicological assessment of HTPs.http://www.sciencedirect.com/science/article/pii/S2214750023000082Heated tobacco productsProduct assessmentProduct stewardshipToxicological assessment |
| spellingShingle | Ruth Dempsey Gregory Rodrigo Florence Vonmoos Irfan Gunduz Maxim Belushkin Marco Esposito Preliminary toxicological assessment of heated tobacco products: A review of the literature and proposed strategy Toxicology Reports Heated tobacco products Product assessment Product stewardship Toxicological assessment |
| title | Preliminary toxicological assessment of heated tobacco products: A review of the literature and proposed strategy |
| title_full | Preliminary toxicological assessment of heated tobacco products: A review of the literature and proposed strategy |
| title_fullStr | Preliminary toxicological assessment of heated tobacco products: A review of the literature and proposed strategy |
| title_full_unstemmed | Preliminary toxicological assessment of heated tobacco products: A review of the literature and proposed strategy |
| title_short | Preliminary toxicological assessment of heated tobacco products: A review of the literature and proposed strategy |
| title_sort | preliminary toxicological assessment of heated tobacco products a review of the literature and proposed strategy |
| topic | Heated tobacco products Product assessment Product stewardship Toxicological assessment |
| url | http://www.sciencedirect.com/science/article/pii/S2214750023000082 |
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