| Summary: | Despite the fact that there are many studies related to the adaptogenic and pro-healthy activities of plant-based compounds, there are some adaptogenic plants whose activities are not fully known, especially those coming from the wild regions of Asia, Africa, and South America. The aim of these studies was to examine the contents of non-nutritional compounds, such as polyphenols, flavonoids, and phenolic acids in ten adaptogenic species (<i>Astragalus membranaceus</i> (AM), <i>Uncaria rhynchophylla</i> (UR), <i>Polygonum multiflorum</i> (PM), <i>Angelica sinensis</i> (AS), <i>Andrographis paniculatea</i> (AP), <i>Tinospora cordifolia</i> (TC), <i>Uncaria tomentosa</i> (UT), <i>Pfaffia paniculate</i> (PP), <i>Sutherlandia frutescens</i> (SF), and <i>Rhaponticum carthamoides</i> (RC)). Considering biological activity, their antioxidant (DPPH, ABTS, FRAP, and ferrous-ion-chelating ability assays), anti-acetylcholinesterase, anti-hyaluronidase, and anti-tyrosinase activities were evaluated. The richest in polyphenols, flavonoids, and phenolic acids was UR (327.78 mg GAE/g, 230.13 mg QE/g, and 81.03 mg CA/g, respectively). The highest inhibitions of acetylcholinesterase, hyaluronidase, and tyrosinase were observed for TC, UR, and PM, respectively. In the case of antioxidant properties, extract from PM appeared to most strongly reduce DPPH, extract from UR inhibited ABTS, and extract from SF showed the best chelating properties. It should be noted that a particularly interesting plant was <i>Ulcaria rhynchophylla</i>. The results mean that there were compounds in UR with broad biological activities, and this species should be explored in more detail. Additionally, our results justify the traditional use of these species in the nutripharmacological or ethnopharmacological care systems of different regions.
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