Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and Africa
Despite the fact that there are many studies related to the adaptogenic and pro-healthy activities of plant-based compounds, there are some adaptogenic plants whose activities are not fully known, especially those coming from the wild regions of Asia, Africa, and South America. The aim of these stud...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/16/6004 |
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| author | Jakub Gębalski Milena Małkowska Filip Graczyk Artur Słomka Elżbieta Piskorska Dorota Gawenda-Kempczyńska Aneta Kondrzycka-Dąda Anna Bogucka-Kocka Maciej Strzemski Ireneusz Sowa Magdalena Wójciak Sebastian Grzyb Krystian Krolik Aneta A. Ptaszyńska Daniel Załuski |
| author_facet | Jakub Gębalski Milena Małkowska Filip Graczyk Artur Słomka Elżbieta Piskorska Dorota Gawenda-Kempczyńska Aneta Kondrzycka-Dąda Anna Bogucka-Kocka Maciej Strzemski Ireneusz Sowa Magdalena Wójciak Sebastian Grzyb Krystian Krolik Aneta A. Ptaszyńska Daniel Załuski |
| author_sort | Jakub Gębalski |
| collection | DOAJ |
| description | Despite the fact that there are many studies related to the adaptogenic and pro-healthy activities of plant-based compounds, there are some adaptogenic plants whose activities are not fully known, especially those coming from the wild regions of Asia, Africa, and South America. The aim of these studies was to examine the contents of non-nutritional compounds, such as polyphenols, flavonoids, and phenolic acids in ten adaptogenic species (<i>Astragalus membranaceus</i> (AM), <i>Uncaria rhynchophylla</i> (UR), <i>Polygonum multiflorum</i> (PM), <i>Angelica sinensis</i> (AS), <i>Andrographis paniculatea</i> (AP), <i>Tinospora cordifolia</i> (TC), <i>Uncaria tomentosa</i> (UT), <i>Pfaffia paniculate</i> (PP), <i>Sutherlandia frutescens</i> (SF), and <i>Rhaponticum carthamoides</i> (RC)). Considering biological activity, their antioxidant (DPPH, ABTS, FRAP, and ferrous-ion-chelating ability assays), anti-acetylcholinesterase, anti-hyaluronidase, and anti-tyrosinase activities were evaluated. The richest in polyphenols, flavonoids, and phenolic acids was UR (327.78 mg GAE/g, 230.13 mg QE/g, and 81.03 mg CA/g, respectively). The highest inhibitions of acetylcholinesterase, hyaluronidase, and tyrosinase were observed for TC, UR, and PM, respectively. In the case of antioxidant properties, extract from PM appeared to most strongly reduce DPPH, extract from UR inhibited ABTS, and extract from SF showed the best chelating properties. It should be noted that a particularly interesting plant was <i>Ulcaria rhynchophylla</i>. The results mean that there were compounds in UR with broad biological activities, and this species should be explored in more detail. Additionally, our results justify the traditional use of these species in the nutripharmacological or ethnopharmacological care systems of different regions. |
| first_indexed | 2024-03-10T23:41:13Z |
| format | Article |
| id | doaj.art-2160e06e7d2140b99c32c54fa68a3dd7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T23:41:13Z |
| publishDate | 2023-08-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2160e06e7d2140b99c32c54fa68a3dd72023-11-19T02:23:14ZengMDPI AGMolecules1420-30492023-08-012816600410.3390/molecules28166004Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and AfricaJakub Gębalski0Milena Małkowska1Filip Graczyk2Artur Słomka3Elżbieta Piskorska4Dorota Gawenda-Kempczyńska5Aneta Kondrzycka-Dąda6Anna Bogucka-Kocka7Maciej Strzemski8Ireneusz Sowa9Magdalena Wójciak10Sebastian Grzyb11Krystian Krolik12Aneta A. Ptaszyńska13Daniel Załuski14Department of Pharmaceutical Botany and Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDepartment of Pharmaceutical Botany and Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDepartment of Pharmaceutical Botany and Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDepartment of Pathophysiology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDepartment of Pathobiochemistry and Clinical Chemistry, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDepartment of Pharmaceutical Botany and Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandUniversity of Social Sciences, 11 Łucka Str., 00-842 Warsaw, PolandDepartment of Biology and Genetics, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Analytical Chemistry, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, PolandDepartment of Analytical Chemistry, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, PolandDepartment of Analytical Chemistry, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, PolandCollege of Engineering and Health in Warsaw, Bitwy Warszawskiej 1920 r. 18 Str., 02-366 Warsaw, PolandDepartment of Pharmaceutical Botany and Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDepartment of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19 Str., 20-033 Lublin, PolandDepartment of Pharmaceutical Botany and Pharmacognosy, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDespite the fact that there are many studies related to the adaptogenic and pro-healthy activities of plant-based compounds, there are some adaptogenic plants whose activities are not fully known, especially those coming from the wild regions of Asia, Africa, and South America. The aim of these studies was to examine the contents of non-nutritional compounds, such as polyphenols, flavonoids, and phenolic acids in ten adaptogenic species (<i>Astragalus membranaceus</i> (AM), <i>Uncaria rhynchophylla</i> (UR), <i>Polygonum multiflorum</i> (PM), <i>Angelica sinensis</i> (AS), <i>Andrographis paniculatea</i> (AP), <i>Tinospora cordifolia</i> (TC), <i>Uncaria tomentosa</i> (UT), <i>Pfaffia paniculate</i> (PP), <i>Sutherlandia frutescens</i> (SF), and <i>Rhaponticum carthamoides</i> (RC)). Considering biological activity, their antioxidant (DPPH, ABTS, FRAP, and ferrous-ion-chelating ability assays), anti-acetylcholinesterase, anti-hyaluronidase, and anti-tyrosinase activities were evaluated. The richest in polyphenols, flavonoids, and phenolic acids was UR (327.78 mg GAE/g, 230.13 mg QE/g, and 81.03 mg CA/g, respectively). The highest inhibitions of acetylcholinesterase, hyaluronidase, and tyrosinase were observed for TC, UR, and PM, respectively. In the case of antioxidant properties, extract from PM appeared to most strongly reduce DPPH, extract from UR inhibited ABTS, and extract from SF showed the best chelating properties. It should be noted that a particularly interesting plant was <i>Ulcaria rhynchophylla</i>. The results mean that there were compounds in UR with broad biological activities, and this species should be explored in more detail. Additionally, our results justify the traditional use of these species in the nutripharmacological or ethnopharmacological care systems of different regions.https://www.mdpi.com/1420-3049/28/16/6004nutripharmacologytyrosinasehyaluronidaseacetylcholinesteraseadaptogensDPPH |
| spellingShingle | Jakub Gębalski Milena Małkowska Filip Graczyk Artur Słomka Elżbieta Piskorska Dorota Gawenda-Kempczyńska Aneta Kondrzycka-Dąda Anna Bogucka-Kocka Maciej Strzemski Ireneusz Sowa Magdalena Wójciak Sebastian Grzyb Krystian Krolik Aneta A. Ptaszyńska Daniel Załuski Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and Africa Molecules nutripharmacology tyrosinase hyaluronidase acetylcholinesterase adaptogens DPPH |
| title | Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and Africa |
| title_full | Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and Africa |
| title_fullStr | Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and Africa |
| title_full_unstemmed | Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and Africa |
| title_short | Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and Africa |
| title_sort | phenolic compounds and antioxidant and anti enzymatic activities of selected adaptogenic plants from south america asia and africa |
| topic | nutripharmacology tyrosinase hyaluronidase acetylcholinesterase adaptogens DPPH |
| url | https://www.mdpi.com/1420-3049/28/16/6004 |
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