Effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen-thawed embryo transfer (FET) cycles of IVF/ICSI: a retrospective study
Abstract Objective The present study aimed to evaluate pregnancy and neonatal outcomes in women, with a previous history of wedge resection for interstitial pregnancy, in frozen-thawed embryo transfer (FET) cycles of IVF/ICSI. Methods The present study involved a retrospective case-control assessmen...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-022-00896-4 |
| _version_ | 1818499374470135808 |
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| author | Shengluan Tang Tong Du Jialyu Huang Hongjuan Ye Ming Zhao Jiaying Lin Yanping Kuang |
| author_facet | Shengluan Tang Tong Du Jialyu Huang Hongjuan Ye Ming Zhao Jiaying Lin Yanping Kuang |
| author_sort | Shengluan Tang |
| collection | DOAJ |
| description | Abstract Objective The present study aimed to evaluate pregnancy and neonatal outcomes in women, with a previous history of wedge resection for interstitial pregnancy, in frozen-thawed embryo transfer (FET) cycles of IVF/ICSI. Methods The present study involved a retrospective case-control assessment of 75 cases and 375 control subjects over 6 years in a single center. To compare pregnancy and neonatal outcomes between cases, treated using wedge resection, and controls without any previous history of ectopic pregnancy, propensity score matching (1:5) was utilized. The study also compared subgroups in the case group. Results Women with previous wedge resection exhibited higher rates of ectopic pregnancy and uterine rupture rate as compared to control subjects (9.1% vs 1.3%, P = 0.025 and 4.5% vs 0%, P = 0.035, respectively). No statistically significant differences were recorded between the two cohorts with regard to clinical pregnancy rate, live birth rate, and neonatal outcomes. For pregnancy type subgroup analysis, Z-score and rates of large for gestational age were recorded to be significantly lower in twin pregnancy subgroup when compared with singleton pregnancy subgroup (0.10 (− 0.59, 0.25) vs 0.50 (− 0.97, 1.39), P = 0.005; 4.5% vs 26.1%, P = 0.047, respectively). Conclusion The results of the present study indicated that previous wedge resection correlated to a higher risk of ectopic pregnancy and uterine rupture. However, it might not be related to an increased risk of adverse neonatal outcomes. The study recommended cesarean section in these patients. Further studies are required to verify the validity of current recommendations. |
| first_indexed | 2024-12-10T20:28:33Z |
| format | Article |
| id | doaj.art-2160e898f3a8413b890007916bb5f814 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-10T20:28:33Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-2160e898f3a8413b890007916bb5f8142022-12-22T01:34:45ZengBMCReproductive Biology and Endocrinology1477-78272022-02-012011910.1186/s12958-022-00896-4Effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen-thawed embryo transfer (FET) cycles of IVF/ICSI: a retrospective studyShengluan Tang0Tong Du1Jialyu Huang2Hongjuan Ye3Ming Zhao4Jiaying Lin5Yanping Kuang6Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Reproductive Medicine Center, Shanghai East Hospital, Tongji University School of MedicineShanghai Towako HospitalDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineAbstract Objective The present study aimed to evaluate pregnancy and neonatal outcomes in women, with a previous history of wedge resection for interstitial pregnancy, in frozen-thawed embryo transfer (FET) cycles of IVF/ICSI. Methods The present study involved a retrospective case-control assessment of 75 cases and 375 control subjects over 6 years in a single center. To compare pregnancy and neonatal outcomes between cases, treated using wedge resection, and controls without any previous history of ectopic pregnancy, propensity score matching (1:5) was utilized. The study also compared subgroups in the case group. Results Women with previous wedge resection exhibited higher rates of ectopic pregnancy and uterine rupture rate as compared to control subjects (9.1% vs 1.3%, P = 0.025 and 4.5% vs 0%, P = 0.035, respectively). No statistically significant differences were recorded between the two cohorts with regard to clinical pregnancy rate, live birth rate, and neonatal outcomes. For pregnancy type subgroup analysis, Z-score and rates of large for gestational age were recorded to be significantly lower in twin pregnancy subgroup when compared with singleton pregnancy subgroup (0.10 (− 0.59, 0.25) vs 0.50 (− 0.97, 1.39), P = 0.005; 4.5% vs 26.1%, P = 0.047, respectively). Conclusion The results of the present study indicated that previous wedge resection correlated to a higher risk of ectopic pregnancy and uterine rupture. However, it might not be related to an increased risk of adverse neonatal outcomes. The study recommended cesarean section in these patients. Further studies are required to verify the validity of current recommendations.https://doi.org/10.1186/s12958-022-00896-4Interstitial pregnancyWedge resectionFrozen embryo transferPregnancy outcomesNeonatal outcomes |
| spellingShingle | Shengluan Tang Tong Du Jialyu Huang Hongjuan Ye Ming Zhao Jiaying Lin Yanping Kuang Effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen-thawed embryo transfer (FET) cycles of IVF/ICSI: a retrospective study Reproductive Biology and Endocrinology Interstitial pregnancy Wedge resection Frozen embryo transfer Pregnancy outcomes Neonatal outcomes |
| title | Effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen-thawed embryo transfer (FET) cycles of IVF/ICSI: a retrospective study |
| title_full | Effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen-thawed embryo transfer (FET) cycles of IVF/ICSI: a retrospective study |
| title_fullStr | Effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen-thawed embryo transfer (FET) cycles of IVF/ICSI: a retrospective study |
| title_full_unstemmed | Effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen-thawed embryo transfer (FET) cycles of IVF/ICSI: a retrospective study |
| title_short | Effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen-thawed embryo transfer (FET) cycles of IVF/ICSI: a retrospective study |
| title_sort | effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen thawed embryo transfer fet cycles of ivf icsi a retrospective study |
| topic | Interstitial pregnancy Wedge resection Frozen embryo transfer Pregnancy outcomes Neonatal outcomes |
| url | https://doi.org/10.1186/s12958-022-00896-4 |
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