Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells

Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells

The spatial and temporal availability of cytokines, and the microenvironments this creates, is critical to tissue development and homeostasis. Creating concentration gradients in vitro using soluble proteins is challenging as they do not provide a self-sustainable source. To mimic the sustained cyto...

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Bibliographic Details
Main Authors: Yuka Matsuzaki, Rina Maruta, Keiko Takaki, Eiji Kotani, Yasuko Kato, Ryoichi Yoshimura, Yasuhisa Endo, Ciara Whitty, Christian Pernstich, Raj Gandhi, Michael Jones, Hajime Mori
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
extracellular matrix
matrix metalloproteinase
neurotrophin
NGF
PC12 cells
polyhedra
protein nanoparticles
Online Access:https://www.mdpi.com/2218-273X/9/10/510

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