Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth
Phthalates are a diverse group of chemicals used in consumer products. Because they are so widespread, exposure to these compounds is nearly unavoidable. Recently, growing scientific consensus has suggested that phthalates produce health effects in developing infants and children. These effects may...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.793278/full |
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| author | Rebekah L. Petroff Vasantha Padmanabhan Vasantha Padmanabhan Vasantha Padmanabhan Dana C. Dolinoy Dana C. Dolinoy Deborah J. Watkins Joseph Ciarelli Diana Haggerty Douglas M. Ruden Jaclyn M. Goodrich |
| author_facet | Rebekah L. Petroff Vasantha Padmanabhan Vasantha Padmanabhan Vasantha Padmanabhan Dana C. Dolinoy Dana C. Dolinoy Deborah J. Watkins Joseph Ciarelli Diana Haggerty Douglas M. Ruden Jaclyn M. Goodrich |
| author_sort | Rebekah L. Petroff |
| collection | DOAJ |
| description | Phthalates are a diverse group of chemicals used in consumer products. Because they are so widespread, exposure to these compounds is nearly unavoidable. Recently, growing scientific consensus has suggested that phthalates produce health effects in developing infants and children. These effects may be mediated through mechanisms related to the epigenome, the constellation of mitotically heritable chemical marks and small compounds that guide transcription and translation. The present study examined the relationship between prenatal, first-trimester exposure of seven phthalates and epigenetics in two pregnancy cohorts (n = 262) to investigate sex-specific alterations in infant blood DNA methylation at birth (cord blood or neonatal blood spots). Prenatal exposure to several phthalates was suggestive of association with altered DNA methylation at 4 loci in males (all related to ΣDEHP) and 4 loci in females (1 related to ΣDiNP; 2 related to BBzP; and 1 related to MCPP) at a cutoff of q < 0.2. Additionally, a subset of dyads (n = 79) was used to interrogate the relationships between two compounds increasingly used as substitutions for common phthalates (ΣDINCH and ΣDEHTP) and cord blood DNA methylation. ΣDINCH, but not ΣDEHTP, was suggestive of association with DNA methylation (q < 0.2). Together, these results demonstrate that prenatal exposure to both classically used phthalate metabolites and their newer alternatives is associated with sex-specific infant DNA methylation. Research and regulatory actions regarding this chemical class should consider the developmental health effects of these compounds and aim to avoid regrettable substitution scenarios in the present and future. |
| first_indexed | 2024-04-13T06:05:50Z |
| format | Article |
| id | doaj.art-21635e4512624764bb55395c4f9189d2 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T06:05:50Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-21635e4512624764bb55395c4f9189d22022-12-22T02:59:15ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-03-011310.3389/fgene.2022.793278793278Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at BirthRebekah L. Petroff0Vasantha Padmanabhan1Vasantha Padmanabhan2Vasantha Padmanabhan3Dana C. Dolinoy4Dana C. Dolinoy5Deborah J. Watkins6Joseph Ciarelli7Diana Haggerty8Douglas M. Ruden9Jaclyn M. Goodrich10Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, United StatesDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, United StatesDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, United StatesDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI, United StatesDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, United StatesDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI, United StatesDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, United StatesDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, United StatesScholarly Activities and Scientific Support, Spectrum Health West Michigan, Grand Rapids, MI, United StatesDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI, United StatesDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, United StatesPhthalates are a diverse group of chemicals used in consumer products. Because they are so widespread, exposure to these compounds is nearly unavoidable. Recently, growing scientific consensus has suggested that phthalates produce health effects in developing infants and children. These effects may be mediated through mechanisms related to the epigenome, the constellation of mitotically heritable chemical marks and small compounds that guide transcription and translation. The present study examined the relationship between prenatal, first-trimester exposure of seven phthalates and epigenetics in two pregnancy cohorts (n = 262) to investigate sex-specific alterations in infant blood DNA methylation at birth (cord blood or neonatal blood spots). Prenatal exposure to several phthalates was suggestive of association with altered DNA methylation at 4 loci in males (all related to ΣDEHP) and 4 loci in females (1 related to ΣDiNP; 2 related to BBzP; and 1 related to MCPP) at a cutoff of q < 0.2. Additionally, a subset of dyads (n = 79) was used to interrogate the relationships between two compounds increasingly used as substitutions for common phthalates (ΣDINCH and ΣDEHTP) and cord blood DNA methylation. ΣDINCH, but not ΣDEHTP, was suggestive of association with DNA methylation (q < 0.2). Together, these results demonstrate that prenatal exposure to both classically used phthalate metabolites and their newer alternatives is associated with sex-specific infant DNA methylation. Research and regulatory actions regarding this chemical class should consider the developmental health effects of these compounds and aim to avoid regrettable substitution scenarios in the present and future.https://www.frontiersin.org/articles/10.3389/fgene.2022.793278/fullphthalatesDNA methylationepigeneticsdevelopmentDOHAD |
| spellingShingle | Rebekah L. Petroff Vasantha Padmanabhan Vasantha Padmanabhan Vasantha Padmanabhan Dana C. Dolinoy Dana C. Dolinoy Deborah J. Watkins Joseph Ciarelli Diana Haggerty Douglas M. Ruden Jaclyn M. Goodrich Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth Frontiers in Genetics phthalates DNA methylation epigenetics development DOHAD |
| title | Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth |
| title_full | Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth |
| title_fullStr | Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth |
| title_full_unstemmed | Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth |
| title_short | Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives and Infant DNA Methylation at Birth |
| title_sort | prenatal exposures to common phthalates and prevalent phthalate alternatives and infant dna methylation at birth |
| topic | phthalates DNA methylation epigenetics development DOHAD |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.793278/full |
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